DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK1 and Sdk1

DIOPT Version :9

Sequence 1:	NP_689957.3	Gene:	SDK1 / 221935	HGNCID:	19307	Length:	2213	Species:	Homo sapiens
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	2213	Identity:	1988/2213 - (89%)
Similarity:	2081/2213 - (94%)	Gaps:	20/2213 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGGDTAGA 65
            ||| ||||.|  |||.|.|||||||||||.|..|.       ...||....||||.|.|   .||
Mouse     1 MAR-ARPSVA--GGGVAAPPERAGPGRPRRSRTGH-------HCDPECPGLRAAPRTPG---PGA 52

Human    66 GRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEG 130
                |||||||.|| |||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse    53 ----GRRAAKLRPG-RGWWALLLLQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEG 112

Human   131 SWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMD 195
            ||||||||:|:|||||||||||||||||||||||||||||||||||||||||||:||||||:|||
Mouse   113 SWPLEFKWIRNDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEIQVAYMGNFMD 177

Human   196 TDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYY 260
            ||||||||||.||:||||||.|.|:|||||||||||||||:||||||||||||||||.|||||||
Mouse   178 TDQRKTVSQGHAALLNLLPIVSCPQPQVTWFREGHKIIPSSRIAITLENQLVILATTASDAGAYY 242

Human   261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDL 325
            ||||||||||||||||||||:|||.||.|.|||.|||.|||||||||||||||||||:|||||:|
Mouse   243 VQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPIIVVAPGNRSVVAGSSETTLECIANARPVEEL 307

Human   326 SVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTA 390
            ||.|||||||:||||||:||||||:||||||||.|||||.|.||.||||||.|||.|||||||||
Mouse   308 SVHWKRNGVRLTSGLHSYGRRLTITNPTSADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTA 372

Human   391 EPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGI 455
            ||||||..|||||:||.|:|||||||||||||||:.:|:|||||||||.||||.||||.||||||
Mouse   373 EPESRILGEVEETMDIPCRAMGVPLPTLQWYKDAVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGI 437

Human   456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHIL 520
            |||||||||||:|||||||||||||.||||||||||||||||:|||||||||||||||||.||||
Mouse   438 FQCFASNEGGEVQTHTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHIL 502

Human   521 ASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVV 585
            ||||||||||||||||||:||||||||||||||||||||.|:||||.|||||||||||||||.||
Mouse   503 ASGSVRIPRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVHPPEDRVV 567

Human   586 IKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIV 650
            ||||||||.||||||||.|||||||||||.:|.||:|||||||||||:||||||||||||:|||:
Mouse   568 IKGTTATLCCGATHDPRTSLRYVWKKDNVVITASSSSRIVVEKDGSLVISQTWSGDIGDYTCEII 632

Human   651 SEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWK 715
            ||||:|||.||||||||||.|||||.|.:.:.||:|.||||||||||||:|||||::||||||||
Mouse   633 SEGGSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYYIVQVSENNSPWK 697

Human   716 VHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780
            ||||||||||||||||||||||||||||||||:||:||||.||||||||||||||||||||||||
Mouse   698 VHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEPPSAPPKNIVASGR 762

Human   781 TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQV 845
            ||||||||||||||||||||||||||||||||||||:|||||:||||||||||||||||||||||
Mouse   763 TNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEHQQRNISSPEVNYCLVTDLIIWTQYEIQV 827

Human   846 AAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAW 910
            ||||||||||||||||||||||||||||||||.|||||||:.|||||||||||||||||||||||
Mouse   828 AAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQAEAVNSTTVHFLWNPPPQQFINGINQGYKLLAW 892

Human   911 PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAV 975
            ||||||.||||||||||||:|||:||||||||||||||||||||||||||:||||||.|||||||
Mouse   893 PADAPETVTVVTIAPDFHGIHHGYITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAV 957

Human   976 GHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTT 1040
            ||||||||||||||||||||||:||||.|||||||||||||||||||||||.|||||||||||||
Mouse   958 GHLSFTEILDTSLKVSWQEPLERNGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTT 1022

Human  1041 YTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIV 1105
            |||||||:||.|.|:.||||||||||||||||||||||||||||||||||||||||||:|.||||
Mouse  1023 YTIDVAALTAAGVGVTTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIV 1087

Human  1106 EGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQ 1170
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||:|.|||||||||
Mouse  1088 EGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQ 1152

Human  1171 APPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235
            |||||||||:||||||||||||||||||||||||||||||||:||||||..|||:||||||||||
Mouse  1153 APPDVAPTSLTVRTASETSLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPSSALAQVVSDRLER 1217

Human  1236 EFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSV 1300
            |.||||||||.||||:||||||:|||||||:|||||||||||||||||||||||||||||||.||
Mouse  1218 ELTIEELEEWTEYELRMQAFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASV 1282

Human  1301 PEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPS 1365
            |||||||||||||:|:.|||||||||||:||||||||||||||||||:|||||||||||||||||
Mouse  1283 PEQDQNGLILGYKVLYCAKDLDPEPRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRIGNGVPS 1347

Human  1366 TPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEV 1430
            :||||||||||.|||||||||||||||:|||||||||||||:||||||||||||.||||||||||
Mouse  1348 SPLILERTKDDTPGPPVRLVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEV 1412

Human  1431 GATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1413 GATVRQFTATELAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1477

Human  1496 RLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
            ||||||||||||||||||:||||||.|||||||||||||||||.|:|||||||||||||||||||
Mouse  1478 RLQWVPGSDGASPIRYFTVQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIG 1542

Human  1561 DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEA 1625
            |||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.
Mouse  1543 DSDFSAETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELESET 1607

Human  1626 GSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASA 1690
            |...|.||||:|.||.||||||||||||||||:.|..|||||||||||||||||||||||||||.
Mouse  1608 GMSPEPKTLKSPSALRAELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIGESPASV 1672

Human  1691 PVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKV 1755
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||||||:||||||||
Mouse  1673 PVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVYYWEADSRNETEKMKV 1737

Human  1756 LFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNV 1820
            ||||||||::|:||||||||:||||||||||||||||.||||||||||.||||||||||||||||
Mouse  1738 LFLPEPVVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNV 1802

Human  1821 SWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTIT 1885
            |||||:||||||||||||||||||||||||||||:|:|||||||||||||||||||||||||||.
Mouse  1803 SWGEPSAANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNWQRWLKVRDLTKGVTYFFRVQARTIA 1867

Human  1886 YGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMF 1950
            ||||||||:|||||||||||||:|||||||||||||||||::|.|||||||||||||||||||||
Mouse  1868 YGPELQANVTAGPAEGSPGSPRNVLVTKSASELTLQWTEGNAGTTPTTGYVIEARPSDEGLWDMF 1932

Human  1951 VKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMA 2015
            .|||||||||||:.||||||||||||||||||:||:||||.||.|||||.|||||||||||||||
Mouse  1933 AKDIPRSATSYTVDLDKLRQGVTYEFRVVAVNKAGFGEPSRPSIAVSAQAEAPFYEEWWFLLVMA 1997

Human  2016 LSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKK 2080
            ||||::||||||.||||||:||||:||||||||.|||:|||||||||||||:|||||||||||||
Mouse  1998 LSSLLLILLVVFVLVLHGQSKKYKSCSTGKGISNMEETVTLDNGGFAALELNSRHLNVKSTFSKK 2062

Human  2081 NGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNH 2145
            ||||||||||||||||||||||||||||||||||:|||||.|.|||||:|||||:||||||||||
Mouse  2063 NGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVNLKEKSVDGSESEASDSDYEEALPKHSFVNH 2127

Human  2146 YMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFS 2210
            ||||||||||||||..  |.||||||||||:|||..||.|||||||||||||||||||.||||||
Mouse  2128 YMSDPTYYNSWKRRPP--AAAPHRYEAVAGAEAGPHLHTVITTQSAGGVYTPAGPGARAPLTGFS 2190

Human  2211 SFV 2213
            |||
Mouse  2191 SFV 2193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK1	NP_689957.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		37/71 (52%)
		I-set	104..188	CDD:254352	80/83 (96%)
		Ig	122..176	CDD:143165	51/53 (96%)
		Ig	219..265	CDD:299845	42/45 (93%)
		IGc2	312..364	CDD:197706	44/51 (86%)
		I-set	386..475	CDD:254352	75/88 (85%)
		Ig	404..472	CDD:143165	56/67 (84%)
		I-set	480..570	CDD:254352	82/89 (92%)
		Ig	494..570	CDD:299845	69/75 (92%)
		I-set	575..664	CDD:254352	76/88 (86%)
		Ig	580..664	CDD:299845	71/83 (86%)
		FN3	668..759	CDD:238020	75/90 (83%)
		fn3	771..857	CDD:278470	83/85 (98%)
		FN3	872..967	CDD:238020	87/94 (93%)
		FN3	972..1054	CDD:238020	76/81 (94%)
		FN3	1070..1166	CDD:238020	90/95 (95%)
		FN3	1176..1271	CDD:238020	84/94 (89%)
		fn3	1279..1365	CDD:278470	79/85 (93%)
		FN3	1378..1471	CDD:238020	88/92 (96%)
		FN3	1477..1572	CDD:238020	89/94 (95%)
		FN3	1580..1694	CDD:238020	99/113 (88%)
		FN3	1704..1797	CDD:238020	85/92 (92%)
		FN3	1802..1883	CDD:238020	76/80 (95%)
		FN3	1903..1996	CDD:238020	81/92 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2098		22/22 (100%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2207..2213		5/5 (100%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		37/71 (52%)
		Ig_2	94..169	CDD:290606	71/74 (96%)
		IG_like	100..169	CDD:214653	65/68 (96%)
		IG_like	183..263	CDD:214653	72/79 (91%)
		Ig	197..247	CDD:299845	44/49 (90%)
		IG_like	281..357	CDD:214653	65/75 (87%)
		IGc2	294..347	CDD:197706	45/52 (87%)
		I-set	368..457	CDD:254352	75/88 (85%)
		Ig	388..454	CDD:143165	55/65 (85%)
		I-set	462..552	CDD:254352	82/89 (92%)
		Ig	476..552	CDD:299845	69/75 (92%)
		I-set	557..646	CDD:254352	76/88 (86%)
		Ig	562..646	CDD:299845	71/83 (86%)
		FN3	650..741	CDD:238020	75/90 (83%)
		fn3	753..839	CDD:278470	83/85 (98%)
		FN3	854..949	CDD:238020	87/94 (93%)
		FN3	954..1036	CDD:238020	76/81 (94%)
		FN3	1052..1148	CDD:238020	90/95 (95%)
		FN3	1158..1253	CDD:238020	84/94 (89%)
		FN3	1261..1349	CDD:238020	81/87 (93%)
		FN3	1360..1453	CDD:238020	88/92 (96%)
		FN3	1459..1554	CDD:238020	89/94 (95%)
		FN3	1562..1676	CDD:238020	99/113 (88%)
		FN3	1686..1779	CDD:238020	85/92 (92%)
		FN3	1784..1865	CDD:238020	76/80 (95%)
		FN3	1885..1978	CDD:238020	81/92 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080		22/22 (100%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83951373
Domainoid	1	1.000	402	1.000	Domainoid score	I11252
eggNOG	1	0.900	-	-		E1_KOG3510
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27395
Inparanoid	1	1.050	4012	1.000	Inparanoid score	I265
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46050
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002891
OrthoInspector	1	1.000	-	-		oto124282
orthoMCL	1	0.900	-	-		OOG6_104033
Panther	1	1.100	-	-	LDO	PTHR13817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4749
SonicParanoid	1	1.000	-	-		X1909
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290