DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK1 and sdk

DIOPT Version :10

Sequence 1:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:2254 Identity:807/2254 - (35%)
Similarity:1160/2254 - (51%) Gaps:202/2254 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   103 APYFKTEPGLP-QIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGF 166
            ||.|.|.|... .|..||:..:|.|.|.|.....::|::|...:..:||...|...|.::.|||.
  Fly    71 APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGS 135

Human   167 YRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQ-RKTVSQGRAAILNLLPITSYPRPQVTWFREGH 230
            |:|:.||..|::...||:|.|||||.|.:|.: |.||..|..||.::.||.|.|.|.|.|..|..
  Fly   136 YQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDG 200

Human   231 KIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPE-TMAPT 294
            .:....:.|.|..|||:||:...:|...|..:|:|.:.|:.::|.|:||:::   |.|. .:||.
  Fly   201 PLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVS---GDPYIEVAPE 262

Human   295 IVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRI-TSGL-HS----FGRRLTISNPT 353
            |:|.|.:..|..|:....|:|||:|||:.:|...|.::|:.: |:|: |:    :.|.|.:....
  Fly   263 IIVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQAN 327

Human   354 SADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTL 418
            |:.:|.|.|:..|....:....|:|.|.|:|||.|.....:....|....|.:.|..:|.|.|.:
  Fly   328 SSHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQV 392

Human   419 QWYKDAISI-SRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTN----- 477
            :|:::|.|: :.:::.||.:.....|.|:||..:|:.:|||.|.||.||....|:|.|..     
  Fly   393 KWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKN 457

Human   478 ----------------------------------------IAPVFTQRPVDTTVTDGMTAILRCE 502
                                                    .||:....|.:.|..||..|.:.|.
  Fly   458 RVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCR 522

Human   503 VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASAT 567
            ..|:|.|.|||......|...|.|:   .:||||.|.|:.:...|||.|.|..||..||:...|.
  Fly   523 AVGSPNPNITWIYNETQLVDISSRV---QILESGDLLISNIRSVDAGLYICVRANEAGSVKGEAY 584

Human   568 LTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP-SSTSRIVVEKDGS 631
            |:|..||.|:.||.|..|:.|.||||.|..:.||.|.....|.::..:.|| |::.||.|:.||.
  Fly   585 LSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADGQ 649

Human   632 LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS--PNSSHSHAVVLSWVRPF 694
            |.|....:.|:|.|:|.:.|.|||::|.|||.|||||..|.|:.|.  | .....::.:||...|
  Fly   650 LEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLP-EPQQRSINVSWTPGF 713

Human   695 DGNSPILYYIV------ELSENNSP---WKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVG 750
            ||||||..:|:      ||.....|   |...||||..:...:.:..|..|..|||||.|||.||
  Fly   714 DGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG 778

Human   751 RGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAG--- 812
            .|..|..::.:.||:|.||.||...|.|.|:...|:.|||||.|...||.:.||||||||.|   
  Fly   779 EGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843

Human   813 LPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQ 877
            :|..||  |||:......|:.:||.|..|.:|:||||..|:||::......|.:|||.|||.||:
  Fly   844 VPWSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVK 906

Human   878 TEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAV------TVVTIAP---DFHGVHHG 933
            .||:|||..:..|.||..|.|||||||||:.||.....:..      .:.|:.|   |.......
  Fly   907 VEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTA 971

Human   934 HITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEK 998
            .:..|:|||.|..||||||.||||..|:...|.|.:|.|..|..|.|.::.|.|:||.|..|...
  Fly   972 ILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPRAS 1036

Human   999 NGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
            |||:|||.:.::|..|.|:..:..|.:...|..:..|.:.|.|..::.|.|.||:|:..::||.|
  Fly  1037 NGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATIQS 1101

Human  1064 GVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEP 1128
            ||.|.||.||:.|.:|||...|..|||.||:||.:||::|.||||...   ...|.|:. |.|:|
  Fly  1102 GVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTAR---NMTWFTIC-EINDP 1162

Human  1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLR 1193
            ||:.|.:..|.|:|.||.|:...|:||.|..|.:::..||:||.|...|.:||||..|...||:|
  Fly  1163 DAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVR 1227

Human  1194 WVPLPDSQYNGNPESVGYRIKYWR-----SDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQ 1253
            |:||..:::.|||.  ||.|.|.:     ..::....:.|:.|.......::.||||..||::|.
  Fly  1228 WIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMN 1290

Human  1254 AFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRA 1318
            |.|.||....|:....||||:|||..|.:|.|.|.|||.:::.|..||.|.:||.|.|||:.:.|
  Fly  1291 ACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAA 1355

Human  1319 KDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVR 1383
            .|...:.....:..|.|.:..|..|:|:|:|.:||||:||:|||..|||.|..:|.:|.||.|..
  Fly  1356 ADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSN 1420

Human  1384 LVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAY 1448
            :.||:|.||..||:|..|.:|||.||.||:.|.|..|:...::. |...:.|.|.||:|.|...|
  Fly  1421 VSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSR-EFPPSDRTFRATELLPGKYY 1484

Human  1449 IFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFT 1513
            .|..:|:||.|||:...|.|.||..||||..|....:.::::.|..:...|.||.||.:|:||:|
  Fly  1485 SFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRYYT 1549

Human  1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVP 1578
            :::|| ..|.||.....:....::.....|||:.:|:.|::||||:|.|.||.|:..|.||...|
  Fly  1550 VEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPAAP 1613

Human  1579 GEPPGSVSATPHTTSSVLIQWQPPRDESLNG--LLQGYRIYYRELEYEAGSGTEAKTLKNPIALH 1641
            ....|.:...|.||:||.:||........||  ...||||.|::|.            ..|.||.
  Fly  1614 AVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRILYQQLS------------DFPTALQ 1666

Human  1642 AELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQ 1706
            :  |.::....:|.:|.    .|:.|::.|.||:::..:|..|..||:.|..|:||||.|...|:
  Fly  1667 S--TPKTDVHGINENSV----VLSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPR 1725

Human  1707 NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYY--------------WEADSQNETEKMKVLF 1757
            .|...|::::::.:.|.||....|||:|.||||||              ||       |:::|:.
  Fly  1726 AVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVVS 1783

Human  1758 LPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSW 1822
            .......|..|...|:|.:.:.|||.|||||:|.|...:|....|.||..|.||:||..:|.|:|
  Fly  1784 ATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVTW 1848

Human  1823 GEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITY 1886
            ..|...||.:.||.|.||.....:..||.|..:|...   .|:|::|.:.|||.|.|:|:| :.|
  Fly  1849 DPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNT---TLRVQNLEEEVTYTFTVRAQTSVDY 1910

Human  1887 GPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFV 1951
            ||.:..|:|.||.:|||.:|||:::||:.|.:.:.|..|.||..|..||:|||:..|:..|....
  Fly  1911 GPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKIE 1975

Human  1952 KDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEP--SNPSTAVSAQV--------EAPFYE 2006
            :........:|:|...|.....|.|||:|.|..|...|  |..|....:::        ..|||.
  Fly  1976 QTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFYR 2040

Human  2007 EWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEES--VTLDNGGFAALEL-SS 2068
            :.||::.:|.:|:::|::|:..|.:..::.|||.    :...|:|||  :::|.....|||| .|
  Fly  2041 QTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQ----EAQKTLEESMAMSIDERQELALELYRS 2101

Human  2069 RH--------------------LNVKSTFSKKNGT---RSPPRPSPGGLHY-SDEDICNKYNGAV 2109
            ||                    |..|||.....|.   :|||||||..:.| |||:....|:.. 
  Fly  2102 RHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESLKCYDEN- 2165

Human  2110 LTESVSLKEKSADASESEA---TDSDYEDA-LPKHSFVNHYMS-DPTYYNSWKRRAQGRAPAPHR 2169
             .:..|:.||.::.|.|||   ::|:.|.. ...|||||||.: :.:...|||:....|     .
  Fly  2166 -PDDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKPVR-----N 2224

Human  2170 YEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV 2213
            |.:...||....   .:.:.:.|.:.......:|.||.||||||
  Fly  2225 YSSYTDSEPEGS---AVMSLNGGQIIVNNMARSRAPLPGFSSFV 2265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
PHA03247 <2..80 CDD:223021
Ig_3 104..173 CDD:464046 22/69 (32%)
Ig 193..274 CDD:472250 28/81 (35%)
Ig strand B 208..212 CDD:409353 2/3 (67%)
Ig strand C 222..226 CDD:409353 1/3 (33%)
Ig strand E 245..248 CDD:409353 2/2 (100%)
Ig strand F 258..263 CDD:409353 1/4 (25%)
Ig_3 293..364 CDD:464046 25/76 (33%)
Ig 386..475 CDD:472250 28/89 (31%)
Ig strand B 404..408 CDD:409353 1/3 (33%)
Ig strand C 417..421 CDD:409353 0/3 (0%)
Ig strand E 441..445 CDD:409353 1/3 (33%)
Ig strand F 455..460 CDD:409353 3/4 (75%)
Ig strand G 468..471 CDD:409353 0/2 (0%)
I-set 480..570 CDD:400151 33/89 (37%)
Ig strand B 497..501 CDD:409353 1/3 (33%)
Ig strand C 510..514 CDD:409353 2/3 (67%)
Ig strand E 536..540 CDD:409353 2/3 (67%)
Ig strand F 550..555 CDD:409353 2/4 (50%)
Ig strand G 563..566 CDD:409353 0/2 (0%)
FN3 <607..1053 CDD:442628 189/469 (40%)
FN3 668..759 CDD:238020 37/101 (37%)
FN3 <937..>1204 CDD:442628 113/266 (42%)
fn3 1176..1264 CDD:394996 32/92 (35%)
FN3 <1251..1595 CDD:442628 137/343 (40%)
FN3 1378..1471 CDD:238020 39/92 (42%)
FN3 <1522..1906 CDD:442628 137/400 (34%)
FN3 1903..1996 CDD:238020 32/94 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098 11/26 (42%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213 4/5 (80%)
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 22/69 (32%)
Ig 280..344 CDD:409353 20/63 (32%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 1/5 (20%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 28/90 (31%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 3/4 (75%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 32/87 (37%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 2/3 (67%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 37/89 (42%)
Ig strand B 608..612 CDD:409353 3/3 (100%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 1/2 (50%)
FN3 686..789 CDD:238020 37/103 (36%)
FN3 798..893 CDD:238020 42/96 (44%)
FN3 901..1005 CDD:238020 44/103 (43%)
FN3 <960..>1261 CDD:442628 122/306 (40%)
fn3 1317..1402 CDD:394996 35/84 (42%)
FN3 1415..1507 CDD:238020 39/92 (42%)
FN3 1513..1608 CDD:238020 32/95 (34%)
FN3 1583..>2011 CDD:442628 159/455 (35%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.