DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK1 and rig-4

DIOPT Version :10

Sequence 1:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens
Sequence 2:NP_501339.2 Gene:rig-4 / 177597 WormBaseID:WBGene00004371 Length:2325 Species:Caenorhabditis elegans


Alignment Length:2418 Identity:668/2418 - (27%)
Similarity:1048/2418 - (43%) Gaps:429/2418 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   104 PYFKTEPGLPQ-IHLEGNRLVLTC----LAEGSWPLEFKWMRDDS--ELTTYSSEYKYI-IPSLQ 160
            |.|:....:.| :.:||..:.|.|    |||     :::|...|:  ||...|   |:. :.:.:
 Worm    29 PIFQDGGSVEQKVAVEGEIIRLKCDDAELAE-----QYEWRIGDASGELIATS---KFCEVQASR 85

Human   161 KLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQ----RKTVSQGRAAILNLLPITSYPRP 221
            ..|...||||.||.:||.:...|.|:..|:..|..:|:    ..|...||..:|.        ||
 Worm    86 VNDEKKYRCVARNTVGAAISPPSMVRSKYLDDFDASDESVQYEVTTGVGRYFVLR--------RP 142

Human   222 QV----------TWFR-EGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSP 275
            .:          :|.: :.|::.|.....:|.:..||:......|.|||.:.|.::...|..:..
 Worm   143 TLLASRNLDISYSWIKDDSHQVTPDATHFVTSDGNLVVTGVKRDDFGAYKLMASSDDLKEIVSKE 207

Human   276 FIHLSIARDVGTPETMAPT--IVVPPGNRSVVAGSSETTL------ECIASARPVEDLSVTWKRN 332
            :    ..||.|...::..|  ||..|.:|:::    |:||      :|:.|....:|:.:.|..|
 Worm   208 Y----NVRDNGLSPSLQNTLSIVYFPTDRTII----ESTLPHDEIFDCVTSFGSKDDVRIRWFLN 264

Human   333 G-------VRITSGLHSFGRRLTISNPTSADTGPYVCEA---ALPGSAFEPARATAFLFIIEPPY 387
            |       |.:|:.|::  |||.||||:|...|.:..|.   |..|...:  :.:|::..|..|.
 Worm   265 GQQISGSEVGMTTTLNN--RRLIISNPSSFTRGEHKLECRADAAMGRTSD--QKSAYMTFISRPI 325

Human   388 FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPED 452
            ....| :.|...|..::.:.|.........::|||:.:.::..:         |.|.|.:::.:|
 Worm   326 LKDLP-NEIQKTVGSSLSLKCSVKKKSSMDIKWYKNGLMMTTQR---------GKLTIDRIKQDD 380

Human   453 SGIFQCFASNEGG------------------------------EIQTHT-------YLD------ 474
            .|::||.|:|..|                              ||...|       :.|      
 Worm   381 FGLYQCEATNAAGADLASVWVKEGEANETVATEMSEDGMSLEEEISMETPPPRKLKFFDNSKSQE 445

Human   475 -----VTNIAP--VFTQRPVDTTVTDGMTAI-LRCEVSGAPKPAITWKRENHILASGSVRIPRFM 531
                 .:.:.|  ...:.|.|.||..|...| :.|..:|:|.|.|.|....|.:.:.:|:..   
 Worm   446 QLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECAATGSPPPNIIWLLNGHEIQTDNVKYD--- 507

Human   532 LLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCG 596
             |.:.||.|..:...|.|.|||..:.:  ::.|:|.:.|...:.|.:.|.|...:.||.....| 
 Worm   508 -LTNDGLAIHDIRKSDEGEYTCEISGS--NVKATANVQVNGDSLIEYGPADQKSLIGTNVEFSC- 568

Human   597 ATHDPRVSLRYV------WKKDNVALTPSSTS--RIVVEKDGSLLISQTWSGDIGDYSCEIVSEG 653
                 .|:..||      |..::|.|..:..|  ||...:.|||:|.|....:.|:|.|.:..:|
 Worm   569 -----EVAKEYVRKASVEWYLNDVLLPVNGNSGLRISRNRKGSLIIRQVGPDNTGEYRCRVTVDG 628

Human   654 GNDSRMARLEVIELPHSPQNLLVS-PNSSHSHAVVLSWVRPFDGNSPILYYIVELSENN-----S 712
            ..::..|.|::||.|..|:.:... .|.:....|.:.|...||||.||:.:.:|:....     |
 Worm   629 REENASAMLQIIEKPAMPERVRAELHNETMPAKVRVRWNEGFDGNEPIIKHAIEMRTMGPTGLWS 693

Human   713 PWKVHLSNVGPEMTG-----VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPP 772
            .|...:.|: |:..|     ..:..|.|:.|.:|||.|.|:.|.|:.|..:..:.:|::||||.|
 Worm   694 DWTTAIDNI-PKEEGKPCCWTDIEDLRPSSTAEFRVVASNKHGPGKPSLPSYSVTMPQQPPSAAP 757

Human   773 KNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPG-EYQQRNITSPEVNYCLVTDLI 836
            :|:.||.|:..|:|||||.|.|...:|.:.||::||||||... .:.::|:|:.:....||.:||
 Worm   758 RNVAASARSPHSVMVQWQQPKEELDSGDVLGYVVRYRLAGYSSLTWNEKNLTTKDARNTLVDELI 822

Human   837 IWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGI 901
            .|.:|||||||||..||||||.::...|.:|.||..|:||:.:.:|||.:...:..|.||.|.|:
 Worm   823 TWREYEIQVAAYNKRGLGVFSESIEVTTSEGRPTQAPKNVRVKVLNSTAVAIEFTAPEQQRIPGV 887

Human   902 NQGYKLLAWPADAP--EAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQL 964
            |.|||:..|..:..  |....|.:.||...: ...:..|:||..|..:.||||||||||.|....
 Worm   888 NLGYKVQFWKGEPEKGELYKQVILDPDRRQL-TTVVNELEKFGHYNLTTLCFTTPGDGPRSNVVK 951

Human   965 VWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHE 1029
            |.|:||.|.:|..||..|::.....::|..||::|||:|.|.|........|.:..|.::.:|..
 Worm   952 VVTEEDTPESVDELSIAEVMYNGAVITWNSPLKQNGIVTKYTIRHWAASSPDVKTKHEVDGSTTN 1016

Human  1030 YKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGY 1094
            :.|.||...|.|.:||.|.|..|.|.|..:...|||||:|||.||.|.|.:||..:..|.|.||:
 Worm  1017 FTIDGLQPSTRYGVDVMASTRKGDGPVEETKFESGVPPELPGRPSMLSIGDISATTVQLHFTPGF 1081

Human  1095 DGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPY 1159
            ||.|:|.:|:|||:   :.|...:..:: ..:.|.|:.:.:..|.|:|.|:.|:...|:.|....
 Worm  1082 DGHTAIRQWVVEGK---MADSSVFAHVF-NVSAPKARSITVTGLRPFTQYQLRLIAENVKGRGAP 1142

Human  1160 SPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSA 1224
            |..||..:|||..||.....:.....|.||:.:.|.||..:.:||.|:  ||.|.|...|.::..
 Worm  1143 SEPSRSFETLQTNPDTPSQRLFAEPVSATSISVSWTPLLATHWNGQPK--GYLIVYREIDDENWK 1205

Human  1225 VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVS 1289
            ..:..:.| ..|.|:.:|..:..||:.:.:.|..|....::.|:.||.|||||.:|.|:...|..
 Worm  1206 EVRTPALR-SSEHTVTDLRPFTSYEVNVFSENGFGRSLPTDSVKARTYESVPSGSPRNIVVTAEG 1269

Human  1290 STQILLTWTSVPEQDQNGLILGYKILF---RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYEL 1351
            |...::.|..|.|...||.::|||:..   |...:..|.:...:.|..|..|.::.||.|..|.:
 Worm  1270 SKAAIIKWNPVAELSTNGDVIGYKLRVVPERESLMADETKVIDIPGQSTLMAKVSDLRPFTSYHV 1334

Human  1352 QVLAFTRIGNGVP-STPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAY 1415
            .:.|:|.:|||.. |||:..| |.:|.|.||.......:....||:.|.||..|||.|..|.|:|
 Worm  1335 YMSAYTIVGNGPENSTPISFE-TMEDVPAPPESFQCSYISEQEVRMKWLPPGSPNGKITNYIISY 1398

Human  1416 RLASSSPHTFT-TVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTE----KRE 1475
             ..|..|.:.. ...:...:..|.|..|.|.:.|.|.:.|:..:|..|...|.|:|:.    .|.
 Worm  1399 -WKSHEPRSMAIDAPLLGNLLMFAAMSLNPNTQYTFAIKARNSKGESEEAVAEVMTSSVRLPVRN 1462

Human  1476 RPAPPRELLVPQAEVTARSLRLQW---VP---GSDGASPIRYFTMQVRELPRGEWQTYSSSISHE 1534
            .|||.|:.|   ::..|..:.::|   :|   ..|..||:|...:..::....||.|......:.
 Worm  1463 APAPVRDTL---SQHQATEIIIRWDESLPRKLTEDAESPVRAVQVSYQKTNEDEWITLEKKFEYS 1524

Human  1535 ATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQW 1599
            ....|:..|.|.:.::.|::...|..:|.:|.|:|.:.||...|...|.|:.|||:..:||.::|
 Worm  1525 KRRSVIKHLSPNSMFRFRIRFIGDFLESSWSPESEWMRTLPSAPFAQPISLKATPYERNSVQLEW 1589

Human  1600 QPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCEL 1664
            ..|...:.|....||||:||  ||.:....:.:    .||:..|          :......:  |
 Worm  1590 VVPHKSTWNSDAIGYRIHYR--EYPSNETWQME----EIAIRDE----------HEDKEEKI--L 1636

Human  1665 THLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPES 1729
            ..|..::.|.:.|..:|..||.|.||||..:||.:.|.....|:...||::|.:.|.||..|.|.
 Worm  1637 AKLDSFKHYILRMRIFNSEGEGPFSAPVFAYVGYSIPKRNLNNIITEPLSSSSIRVKWDAWPKED 1701

Human  1730 QNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDP 1792
            .. .|..:|:.|....|  .:.:.:.:::.:......|.:|...|:|.:|:|.:|.||:| |...
 Worm  1702 SE-TITSFKVRYVPVASVLSSVSSEEEIMIVDTNECTLNDLRKFTEYQISVSPYNRAGEG-KMSQ 1764

Human  1793 QQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVR 1857
            .:.:|.:..||....|.||::...::.|||.||:..||.:.||.|.|:...        :..|.:
 Worm  1765 VRDKTLEDKPGPVGILRFSDVLMDSVKVSWDEPSQPNGNVIGYIVNYKGYR--------MQEEFK 1821

Human  1858 GNWQR-----WLKVRDLTKGVTYFFRVQARTIT-YGPELQANITAGPAEGSPGSPRDVLVTKSAS 1916
            ...|:     :.....|.:||||||.|.|.|.. .|.:..||:|.||::..|..|....:|...|
 Worm  1822 NEDQQRTSRNYFDTHGLAEGVTYFFSVWAETSAGKGEQRSANVTIGPSKDGPPPPSKPQITSGQS 1886

Human  1917 ELTLQWTE--------GH---------SGDTPTTGYVIE---------------------ARPSD 1943
            .:||.|.:        ||         :.:.|..|||.:                     .||:.
 Worm  1887 YVTLNWNDVADSDEIVGHLLQAKRVSVAEEAPANGYVSQRPRRNEIKGAKSAAQTAAATSTRPTH 1951

Human  1944 E-GLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEA----- 2002
            . |.| :.::.....:....:|..:|:....|.|||...|..|.|         .|.||.     
 Worm  1952 PIGEW-ITLRPTEGRSEKEQVSYRELQPSSYYAFRVFTRNVRGIG---------MASVETEQLFV 2006

Human  2003 -------PFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGG 2060
                   |||..|||:.::|:.:.::|::::..|.:.|.:.||:.....:.|    :|:.|.:|.
 Worm  2007 PESIPDDPFYTTWWFMALVAMGAFVLIVIIIAILCVTGSSAKYRREKRSRSI----DSLQLADGN 2067

Human  2061 FAALELS---------SRHLNVK--------STFSKK--------NGTRS--------------- 2085
            ||:.:|.         ||.|..:        |..|::        .|:|:               
 Worm  2068 FASFQLKGTSAANMTRSRELPTRPGTTQSWVSDQSREPPAYGSVLGGSRNSGGVMNMYGLATDVI 2132

Human  2086 PPRPSPGGLHYSDE-----------DICNKYNGAVLTESV------SLKEKSADASESEATDSDY 2133
            ||.|:.|..|.|.|           || ...|.|.:|.|.      ...|.....|:..||.|:|
 Worm  2133 PPLPNSGPPHTSVEAMQKLSALVGRDI-RSQNTAYVTPSARGGSDNGRNEYMPTRSDLYATRSEY 2196

Human  2134 ---------------------------------------EDALPKHSFV--------------NH 2145
                                                   ||.:...:.:              .|
 Worm  2197 GRVEYRGHIPSSSGGSGAGSQPQGSPLQQPEVYDSFDEEEDVVDDDTVIRGDRTMTDGVDDIARH 2261

Human  2146 YMSDPTYYNSWKR-RAQGRAPAP----HRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTP 2205
            |.|...|.::|:: |......||    |...|...|.         ||.|     |..||.|..|
 Worm  2262 YGSTDQYRDTWRKVRDTDMVRAPILTGHPSSAAGRSS---------TTDS-----TSEGPWANIP 2312

Human  2206 -----LTGFSSFV 2213
                 .|||||||
 Worm  2313 ATPNLTTGFSSFV 2325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
PHA03247 <2..80 CDD:223021
Ig_3 104..173 CDD:464046 21/76 (28%)
Ig 193..274 CDD:472250 20/95 (21%)
Ig strand B 208..212 CDD:409353 1/3 (33%)
Ig strand C 222..226 CDD:409353 0/13 (0%)
Ig strand E 245..248 CDD:409353 1/2 (50%)
Ig strand F 258..263 CDD:409353 2/4 (50%)
Ig_3 293..364 CDD:464046 26/85 (31%)
Ig 386..475 CDD:472250 22/136 (16%)
Ig strand B 404..408 CDD:409353 0/3 (0%)
Ig strand C 417..421 CDD:409353 0/3 (0%)
Ig strand E 441..445 CDD:409353 2/3 (67%)
Ig strand F 455..460 CDD:409353 2/4 (50%)
Ig strand G 468..471 CDD:409353 0/2 (0%)
I-set 480..570 CDD:400151 26/92 (28%)
Ig strand B 497..501 CDD:409353 1/4 (25%)
Ig strand C 510..514 CDD:409353 1/3 (33%)
Ig strand E 536..540 CDD:409353 2/3 (67%)
Ig strand F 550..555 CDD:409353 3/4 (75%)
Ig strand G 563..566 CDD:409353 1/2 (50%)
FN3 <607..1053 CDD:442628 167/467 (36%)
FN3 668..759 CDD:238020 28/101 (28%)
FN3 <937..>1204 CDD:442628 98/266 (37%)
fn3 1176..1264 CDD:394996 22/87 (25%)
FN3 <1251..1595 CDD:442628 104/358 (29%)
FN3 1378..1471 CDD:238020 28/93 (30%)
FN3 <1522..1906 CDD:442628 111/391 (28%)
FN3 1903..1996 CDD:238020 26/131 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098 9/45 (20%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213 5/5 (100%)
rig-4NP_501339.2 IG_like 330..402 CDD:214653 17/81 (21%)
Ig strand B 341..345 CDD:409568 0/3 (0%)
Ig strand C 354..358 CDD:409568 0/3 (0%)
Ig strand E 369..373 CDD:409568 2/3 (67%)
Ig strand F 383..388 CDD:409568 2/4 (50%)
Ig strand G 396..399 CDD:409568 0/2 (0%)
Ig 459..543 CDD:472250 25/89 (28%)
Ig strand B 476..480 CDD:409353 1/3 (33%)
Ig strand C 489..493 CDD:409353 1/3 (33%)
Ig strand E 511..515 CDD:409353 2/3 (67%)
Ig strand F 525..530 CDD:409353 3/4 (75%)
Ig strand G 536..539 CDD:409353 1/2 (50%)
IG_like 553..639 CDD:214653 25/91 (27%)
Ig strand B 564..568 CDD:409353 0/3 (0%)
Ig strand C 579..583 CDD:409353 0/3 (0%)
Ig strand E 605..609 CDD:409353 3/3 (100%)
FN3 <614..>874 CDD:442628 95/260 (37%)
Ig strand F 619..624 CDD:409353 2/4 (50%)
FN3 756..850 CDD:238020 44/93 (47%)
FN3 858..954 CDD:238020 36/96 (38%)
fn3 965..1042 CDD:394996 25/76 (33%)
FN3 1057..1151 CDD:238020 33/97 (34%)
FN3 1156..1251 CDD:238020 25/97 (26%)
FN3 <1218..>1470 CDD:442628 80/253 (32%)
FN3 1464..1560 CDD:238020 23/98 (23%)
FN3 1572..1664 CDD:238020 31/109 (28%)
FN3 <1645..>1896 CDD:442628 79/260 (30%)
FN3 1774..1858 CDD:238020 28/91 (31%)
Blue background indicates that the domain is not in the aligned region.

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