DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK1 and sdk2

DIOPT Version :10

Sequence 1:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens
Sequence 2:XP_031750128.1 Gene:sdk2 / 100485585 XenbaseID:XB-GENE-990316 Length:2174 Species:Xenopus tropicalis


Alignment Length:2183 Identity:1242/2183 - (56%)
Similarity:1623/2183 - (74%) Gaps:57/2183 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    78 PGRRG--WWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMR 140
            ||..|  |..|.|||: |....|||||.|||||||...|:|||||||||||:|||||||||||:|
 Frog     2 PGTWGKLWICLAALQI-LCPCWAQDDVPPYFKTEPVRSQVHLEGNRLVLTCMAEGSWPLEFKWLR 65

Human   141 DDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQG 205
            |..|||.:|.||:|:|.||.:..||:|.|:||||||||||||:||||||||:|.|.|...:||.|
 Frog    66 DHKELTKFSLEYRYMITSLDRTHAGYYCCIVRNRMGALLQRKTEVQVAYMGNFEDGDTSLSVSHG 130

Human   206 RAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGE 270
            .||::|...|.|:|:|||||||:|.||.|:||||||..|.||||::...|.|.|||||||:|||:
 Frog   131 DAAVINAPNIASFPQPQVTWFRDGRKIPPTNRIAITKNNTLVILSSVAPDTGRYYVQAVNDKNGD 195

Human   271 NKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVR 335
            ||||..|.|::....|..:.:||.|::||.|.|||.|:||.::||:|:|||:..|::.||:|||.
 Frog   196 NKTSQPITLTVENVGGPADPIAPIIIIPPQNTSVVTGTSEVSMECVANARPLTKLNIVWKKNGVP 260

Human   336 ITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEV 400
            :::|:..|||.|||.||..:|.|.|.|||.|..|:..|..|.|:|.::|||.|..||:..::||:
 Frog   261 LSNGVTEFGRFLTILNPVLSDAGYYSCEATLRSSSVPPVSAGAYLTVLEPPQFVKEPDRHLTAEM 325

Human   401 EETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGG 465
            |:.|:|.|||.|||.|.:.|||||:.|...::.|:::::||.|||..|.|:|:|:|||||.||.|
 Frog   326 EKVVEIPCQAKGVPQPIISWYKDAVLIDIRRDARFRLVSSGSLRISGLIPDDTGMFQCFARNEAG 390

Human   466 EIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRF 530
            |:||.|||.||:|||..|:.|.||||.||...:|:||.||||:|||||::.:.:|||||:::|||
 Frog   391 EVQTSTYLAVTSIAPNITRAPQDTTVIDGTAVVLQCETSGAPRPAITWQKGDRVLASGSIQLPRF 455

Human   531 MLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHC 595
            .|||||.|.|:|..|.|.|.|||.|.|:.|:.:|||.:.||.||.|.:||.|..|||||.|::.|
 Frog   456 TLLESGSLLISPAHISDTGTYTCSATNSRGADDASADIIVWARTRITNPPSDQSVIKGTKASMSC 520

Human   596 GATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMA 660
            |.:||..|::||||:||...::..::.||.::|:|:|.||||||||||.|:|.::|.||||||.|
 Frog   521 GVSHDSSVAIRYVWEKDGFPVSVENSPRIQLDKNGTLHISQTWSGDIGTYTCRVLSVGGNDSRSA 585

Human   661 RLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEM 725
            .|.|.:|||:|:|.:.:.:...|.|:.|:||:|||||||:|.||||:||||:||.:.|.::.||.
 Frog   586 HLRVRQLPHAPENPVATLSLVESRAINLTWVKPFDGNSPLLRYIVEVSENNAPWTILLGSLDPEQ 650

Human   726 TGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQ 790
            |.:.|..|.|||:||||:||.|:||:||:|.:|.|:.||||||||||:|::||||||||||:|||
 Frog   651 TALVVRNLVPARSYQFRLCAANDVGKGQFSKDTQRVSLPEEPPSAPPQNVMASGRTNQSIMIQWQ 715

Human   791 PPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGV 855
            |.||...||:|:||::||.|:|||..||.||:::|.:|:.|:.||||||.|||:|||:|.||:||
 Frog   716 PAPENHQNGILKGYVVRYCLSGLPVGYQYRNLSNPSINHLLLEDLIIWTNYEIEVAAFNSAGVGV 780

Human   856 FSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTV 920
            ||..|||:|||||||.||:||:|||||||.|:|.||||..||:|||||||||:.|.....:.:.|
 Frog   781 FSGKVTEWTLQGVPTVPPENVKTEAVNSTAIRFTWNPPSPQFVNGINQGYKLMVWEPGQEDEIMV 845

Human   921 VTIAPDF-HGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEIL 984
            :|:.|.| ...|.|.|:.|||||:|.||:||||||||||.|.|||||||||.||.||||||.:||
 Frog   846 ITVRPKFQENTHVGIISGLKKFTSYITSILCFTTPGDGPRSQPQLVWTQEDVPGPVGHLSFDDIL 910

Human   985 DTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVT 1049
            ||||:|:||||.||||::|||:||||.:.:.::|:||.|.:.|.||::.||:|||||||.||.:|
 Frog   911 DTSLRVTWQEPAEKNGLLTGYKISWEEFNQTNTRVTHYLPNVTLEYRVTGLTSLTTYTIQVAGMT 975

Human  1050 AVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGD 1114
            :.|.|:|:||||||||||:||||||||.||||..||.|||||||:|||||||:|:||.|||...:
 Frog   976 SKGQGVVSSSTISSGVPPELPGAPSNLGISNIGSRSVTLQFRPGFDGKTSISKWLVEAQVGNPTE 1040

Human  1115 EEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTS 1179
            .::||.:|:..|||:|:.|.:..|.||.:|.|||:||||||.||.|..||.||||||||.:.|.:
 Frog  1041 SDDWVLIYQLANEPNARSLGVSGLRPYNYYSFRMRQVNIVGTSPPSLPSRRIQTLQAPPSMFPAN 1105

Human  1180 VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEE 1244
            .|:||||:|||.:||||||:.:|||||:||||:|:|.|.|.:......|:.||:|||:|||:|||
 Frog  1106 ETLRTASQTSLWVRWVPLPEMEYNGNPDSVGYKIRYARLDKKGKPFTHVIYDRIEREYTIEDLEE 1170

Human  1245 WMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
            |.||.:|:|||||:||||||.|:..||||||||:.|.||||.|.:|:.||:.|:.:||.::||||
 Frog  1171 WTEYAVQIQAFNAIGAGPWSPVITARTRESVPSSGPTNVSALATTSSSILVRWSEIPEPERNGLI 1235

Human  1310 LGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTK 1374
            ||||:|::.||.|......:|.||.::||.|:||.|:||||:|||||||||:|..|||.|||||.
 Frog  1236 LGYKVLYKEKDSDTSTHFWLVEGNSSRSAQLSGLGKYVLYEIQVLAFTRIGDGAASTPAILERTL 1300

Human  1375 DDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTA 1439
            ||.|||||.::|||||.||||::||||..||||||.|||.:||.:::.:|.|...:..:|||:||
 Frog  1301 DDVPGPPVGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNATNANTATVEVLNPSVRQYTA 1365

Human  1440 TDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSD 1504
            |.|.|||.|:||::|:||:||||..||.|:|||||:||.||.:..|.|.:|.||::.|.|.||||
 Frog  1366 TALRPESIYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSKPTVLQEDVKARTVLLSWDPGSD 1430

Human  1505 GASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETE 1569
            |.||:||:|:|..|||:|:|..:|::|||.:|:.|||||:||||||.|:|||||||||::|.|:|
 Frog  1431 GLSPVRYYTIQTLELPKGKWVVHSATISHNSTSAVVDRLKPFTSYKFRVKATNDIGDSEYSEESE 1495

Human  1570 AVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTL 1634
            |:||||..|||.|..:|..||||:||||:||.|.::.:||:|.|:.|.:|||.|:.......:::
 Frog  1496 ALTTLQAAPGEAPTILSVNPHTTTSVLIRWQAPAEDRINGILLGFCIRFRELAYDGLRSFTMQSI 1560

Human  1635 KNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEA 1699
            .||.|..|||||....:.: |..|.|..||.:|.|::|||:.::.||..||.|:|.|.|||||||
 Frog  1561 NNPGAKWAELTASYMMRNL-SEPTLTQYELDNLNKHKRYEIRVSMYNAAGEGPSSVPQEVFVGEA 1624

Human  1700 APAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVR 1764
            .|...|||:.:...||.||:|||:|||.|:|||:||||||:|||...:|||||::.|||||..|:
 Frog  1625 VPTAPPQNIAIASTTAVQLDVTWEPPPLEAQNGDIQGYKIFYWEILRKNETEKVRTLFLPETGVK 1689

Human  1765 LKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAAN 1829
            |||||.:|.||:|::|||||||||:..|.:|:|.||||.||:.:.|||:|:|::||||..|...|
 Frog  1690 LKNLTGYTTYLISVAAFNAAGDGPRGQPIRGQTQQAAPSAPASIRFSELTTTSVNVSWDAPIYPN 1754

Human  1830 GILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANI 1894
            |||:|||:||||..||.|:||:|||:|:||...|:||:||.:||||.||::|:|.||||:::||:
 Frog  1755 GILEGYRLVYEPCTPVDGISKIVTVDVKGNSPLWMKVKDLAEGVTYRFRIRAKTFTYGPDIEANV 1819

Human  1895 TAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSAT 1959
            |.||.||:||.|.:..:::.:|.:|:.|:.|..|.:|.|.|:||||||||||||:.:||||:.||
 Frog  1820 TTGPGEGAPGPPGEPFISRYSSAITIHWSSGDPGKSPITRYIIEARPSDEGLWDILIKDIPKEAT 1884

Human  1960 SYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILL 2024
            |||.|:|.|:|||:|:|||:|||:.|||.||.||.:||||...|||||||||:|:||..||.|||
 Frog  1885 SYTFSIDILKQGVSYDFRVIAVNDYGYGTPSAPSPSVSAQKANPFYEEWWFLVVIALIGLIFILL 1949

Human  2025 VVFALVLHGQNKKY----------KNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSK 2079
            :||||::.||:|||          |..|.|.|     |.|:||...|.||||::|.|:||::|.:
 Frog  1950 LVFALIIRGQSKKYAKKSDSACNPKTNSLGHG-----EMVSLDESRFPALELNNRRLSVKNSFCR 2009

Human  2080 KNG--TRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYE---DALPK 2139
            |||  ||||||||||.|||||||: .|||..:.|||.||.||.::.|:|:.:||:||   :....
 Frog  2010 KNGIYTRSPPRPSPGSLHYSDEDV-TKYNDLIPTESGSLTEKPSEVSDSQGSDSEYEVDQNQQKT 2073

Human  2140 HSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSA---GGVYTP---- 2197
            |||||||:|||||||||:|:.:|.:.| |.|. .:.:|.....|.:|...::   |.:|.|    
 Frog  2074 HSFVNHYISDPTYYNSWRRQQKGISRA-HAYN-YSENEPEDSDHCIIPNSNSSHQGSLYRPKASR 2136

Human  2198 ----------------------AGPGARTPLTGFSSFV 2213
                                  ..|.||.|:.||||||
 Frog  2137 TPTPQQSHSLPSQNPIYRPPSSLAPAARAPIAGFSSFV 2174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
PHA03247 <2..80 CDD:223021 1/1 (100%)
Ig_3 104..173 CDD:464046 47/68 (69%)
Ig 193..274 CDD:472250 48/80 (60%)
Ig strand B 208..212 CDD:409353 1/3 (33%)
Ig strand C 222..226 CDD:409353 3/3 (100%)
Ig strand E 245..248 CDD:409353 1/2 (50%)
Ig strand F 258..263 CDD:409353 3/4 (75%)
Ig_3 293..364 CDD:464046 36/70 (51%)
Ig 386..475 CDD:472250 46/88 (52%)
Ig strand B 404..408 CDD:409353 2/3 (67%)
Ig strand C 417..421 CDD:409353 0/3 (0%)
Ig strand E 441..445 CDD:409353 2/3 (67%)
Ig strand F 455..460 CDD:409353 3/4 (75%)
Ig strand G 468..471 CDD:409353 2/2 (100%)
I-set 480..570 CDD:400151 49/89 (55%)
Ig strand B 497..501 CDD:409353 1/3 (33%)
Ig strand C 510..514 CDD:409353 3/3 (100%)
Ig strand E 536..540 CDD:409353 2/3 (67%)
Ig strand F 550..555 CDD:409353 3/4 (75%)
Ig strand G 563..566 CDD:409353 1/2 (50%)
FN3 <607..1053 CDD:442628 270/446 (61%)
FN3 668..759 CDD:238020 48/90 (53%)
FN3 <937..>1204 CDD:442628 174/266 (65%)
fn3 1176..1264 CDD:394996 53/87 (61%)
FN3 <1251..1595 CDD:442628 207/343 (60%)
FN3 1378..1471 CDD:238020 54/92 (59%)
FN3 <1522..1906 CDD:442628 216/383 (56%)
FN3 1903..1996 CDD:238020 52/92 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098 17/24 (71%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213 4/5 (80%)
sdk2XP_031750128.1 Ig_3 28..98 CDD:464046 47/69 (68%)
Ig 124..206 CDD:472250 49/81 (60%)
Ig strand C 147..151 CDD:409406 3/3 (100%)
Ig strand E 170..173 CDD:409406 1/2 (50%)
Ig strand F 183..206 CDD:409406 16/22 (73%)
Ig 236..290 CDD:409353 26/53 (49%)
Ig strand B 236..240 CDD:409353 0/3 (0%)
Ig strand C 251..255 CDD:409353 0/3 (0%)
Ig strand F 284..289 CDD:409353 2/4 (50%)
Ig 311..400 CDD:472250 46/88 (52%)
Ig strand B 329..333 CDD:409353 2/3 (67%)
Ig strand C 342..346 CDD:409353 0/3 (0%)
Ig strand E 366..370 CDD:409353 2/3 (67%)
Ig strand F 380..385 CDD:409353 3/4 (75%)
Ig strand G 393..396 CDD:409353 2/2 (100%)
I-set 405..495 CDD:400151 49/89 (55%)
Ig strand B 422..426 CDD:409544 1/3 (33%)
Ig strand C 435..439 CDD:409544 3/3 (100%)
Ig strand E 461..465 CDD:409544 2/3 (67%)
Ig strand F 475..480 CDD:409544 3/4 (75%)
Ig strand G 488..491 CDD:409544 1/2 (50%)
Ig 499..593 CDD:472250 49/93 (53%)
Ig strand B 516..520 CDD:409359 1/3 (33%)
Ig strand C 531..535 CDD:409359 3/3 (100%)
Ig strand E 555..559 CDD:409359 2/3 (67%)
Ig strand F 569..574 CDD:409359 2/4 (50%)
Ig strand G 582..585 CDD:409359 2/2 (100%)
FN3 593..684 CDD:238020 48/90 (53%)
FN3 716..1223 CDD:442628 317/506 (63%)
FN3 898..986 CDD:238020 53/87 (61%)
fn3 1206..1291 CDD:394996 47/84 (56%)
FN3 1285..1800 CDD:442628 294/515 (57%)
FN3 1403..1498 CDD:238020 56/94 (60%)
FN3 <1697..>1928 CDD:442628 134/230 (58%)
Blue background indicates that the domain is not in the aligned region.

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