Protein Alignment GPC2 and dlp

DIOPT Version :10

• Sequence 1: NP_689955.1
• Gene: GPC2 / 221914
• HGNCID: 4450
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 165/674 - (24%)
• Similarity: 272/674 - (40%)
• Gaps: 142/674 - (21%)

Human     6 PLLLLLLP--LCP------GPGP------GPGSEAKVTRS---------CAETRQVLGARGYSLN 47
            |||||||.  |.|      ||.|      .|.....|..|         |:....:..|||....
  Fly    31 PLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAI 95

Human    48 LIPPALISGEHLRVC--PQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEF 110
            .||....:...||.|  |...|||:...|.|:..::.....|..:|..|.:...|.::..||.:.
  Fly    96 EIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDI 160

Human   111 FLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVF 175
            |..:|..::.....:|..:||.:|.:::.:|:.||..|..::......|.:.:..|:..|.:::|
  Fly   161 FTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMF 225

Human   176 PLLHPQYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSE 240
            .:|:.||:|..:|:.|:|....    .|:||||.|.:|.:||.|:.||.|.:.|.|.|...|..:
  Fly   226 TVLNTQYTFDENYMRCVSEHMK----ELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKK 286

Human   241 ALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLS-SRGLEPDWGNYLDGLLILA 304
            .|.|.::..|:.||.::..|..|:|... .||..:|:||::|||. ....:.:|.|:...:..:|
  Fly   287 VLNVRLNADCTGALTKMQHCGACKGYTE-KPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVA 350

Human   305 DKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPP-------------------- 349
            ::|.|.|:..:..|.:.:||||.:|..|::...::.:|||.||.|
  Fly   351 ERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILN 415

Human   350 --DPVPA---------------RNRRAPPPREEAGRLWSMVTEEERPTTAAGTN----------- 386
              .||.|               |.|||..|..:.   .|....:|:....:|..
  Fly   416 ARSPVEADTLDIDETLDEAIVLRERRAAEPGSQE---TSAQQSQEQGVGKSGNGGGGGGGNNRRQ 477

Human   387 ----------------------------------LHRLVWELRERLARMRGFWARLSLTVCGDSR 417
                                              |.|:|.::|:|:...:.||:.|..:||.:..
  Fly   478 QQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNED 542

Human   418 MAADASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRR------RRLQLRA 476
            :|:.:.::.. ||.|....||:..:.    .|..:|||.    :|....|::      :...|:.
  Fly   543 IASSSDVDGM-CWNGHTIDRYMHSIT----TEHGSNPEF----TGNPASTKQTAQMASQLSHLKN 598

Human   477 ATARMKTAALGHDLDGQDADE-----DASGSGGGQQYADDWMAGAVAPPARP------PRPPYPP 530
            |...::.|..|.|::..:.:|     ..:|||.|.:..:|...|:...|..|      .||....
  Fly   599 AIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSHKPDVERPSVDA 663

Human   531 RRDGSGGKGGGGSARYNQGRSRSG 554
            ..|.....||.|....:..|..||
  Fly   664 DNDDDEDAGGRGHMPTHTSRPTSG 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC2	NP_689955.1	Glypican	29..512	CDD:460084	138/587 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..468		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..555		20/81 (25%)
dlp	NP_524071.2	Glypican	79..619	CDD:460084	132/556 (24%)