DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tyro3 and Eph

DIOPT Version :9

Sequence 1:NP_062265.2 Gene:Tyro3 / 22174 MGIID:104294 Length:880 Species:Mus musculus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:724 Identity:185/724 - (25%)
Similarity:291/724 - (40%) Gaps:194/724 - (26%)


- Green bases have known domain annotations that are detailed below.


Mouse   213 APPAAPFNTTVTTISSYNASVAWVPGADGLA--------LLHS----------CTVQVAHAPGEW 259
            :|||||.|.|:..:...:|.::|...|...:        :.||          |:..|.:.|.  
  Fly   385 SPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPS-- 447

Mouse   260 EALAVVVPVPPFT---CLLRNLAPATNYSLRVRCANALGPSPYGDW--------------VPFQT 307
                    ...|.   ..|.||.|.|.|::::...|::  |...::              :.|..
  Fly   448 --------TDTFNETKITLTNLEPVTTYTVQIHAINSV--SHINEFKRHSNESSLVAVSDIVFSN 502

Mouse   308 KGLAPARAPQNFHAIRTDSGLI--------------------------LEWEEVIPEDPGEGPLG 346
            ..|  ...|.:.:.::|....|                          |||::.:..|   .||.
  Fly   503 TSL--LNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD---FPLE 562

Mouse   347 PYKLSW---VQENG-TQDELMVEGTRANLTDWDPQKDLILRV-CASNAIGDGPWSQPLVVSSHDH 406
            .|::.|   |:.:. .:..|..:.|:|::.......:...:| |.:|. |.|.:|..:...:...
  Fly   563 FYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN-GFGSYSNMIYAQTLQS 626

Mouse   407 AGRQGPPHSRTSWV--PVVLGVLTALITAAALALILLRKR-----RKETR--------------- 449
            .|.......:..::  .:|.|||..:|...|....:..|.     :|.|.               
  Fly   627 VGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNS 691

Mouse   450 ------------------FGQAFDSVMARGEPAVH---FRAARSFNRERPERIEATLDSLGISDE 493
                              ||.:...|    :|..:   .:|.|.|.||                 
  Fly   692 MDTTPIVKKLHLNVTTPLFGNSRSYV----DPHTYEDPNQAIREFARE----------------- 735

Mouse   494 LKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVK---VAVKMLKADIIASSDIE-- 553
                     |.....|:..::|.||||.|...:||... :||:   ||:|.||.   .||:..  
  Fly   736 ---------IDANYITIEAIIGGGEFGDVCRGRLKIPP-NFVQDIDVAIKTLKP---GSSEKARC 787

Mouse   554 EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLP 618
            :||.||:.|.:||||:|..|.||..||.     |: |:|..:|::|.|..||   |:.:..|. .
  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSN-----PV-MIITEYMENGSLDTFL---RVNDGKFQ-T 842

Mouse   619 LQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDYYRQGCA 681
            ||.:| .:..||.||.|||..|::||||||||.::...:...:|||||||:|  .|..|..:|  
  Fly   843 LQLIV-MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-- 904

Mouse   682 SKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPE 746
            .|:||:|.|.|::|...:|..||||::||.:||:|:.|:.||....|.::...:..|.||..|.:
  Fly   905 GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMD 969

Mouse   747 CMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH-LSVLSTSQDPLYINIERAEQPTESGSPE 810
            |.|.:|.||..||......||:|..:...|:|:... .|:|:|...|            ||....
  Fly   970 CPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP------------ESDGNH 1022

Mouse   811 VHCGERSSS 819
            :..|:|..:
  Fly  1023 ILDGQRGQN 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tyro3NP_062265.2 IG_like 39..125 CDD:214653
IGc2 46..111 CDD:197706
Ig 131..209 CDD:299845
IG_like 135..204 CDD:214653
FN3 215..307 CDD:238020 24/126 (19%)
fn3 315..396 CDD:278470 20/111 (18%)
PTKc_Tyro3 498..781 CDD:270659 111/289 (38%)
Pkinase_Tyr 508..776 CDD:285015 108/274 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..864 4/20 (20%)
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 21/98 (21%)
FN3 536..623 CDD:238020 18/90 (20%)
EphA2_TM 644..736 CDD:291255 18/121 (15%)
PTKc_EphR 736..1002 CDD:270629 110/282 (39%)
Pkinase_Tyr 741..999 CDD:285015 108/274 (39%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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