DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM24 and HRP1

DIOPT Version :9

Sequence 1:	NP_001137414.1	Gene:	RBM24 / 221662	HGNCID:	21539	Length:	236	Species:	Homo sapiens
Sequence 2:	NP_014518.1	Gene:	HRP1 / 853997	SGDID:	S000005483	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	184	Identity:	46/184 - (25%)
Similarity:	72/184 - (39%)	Gaps:	58/184 - (31%)

- Green bases have known domain annotations that are detailed below.

Human     5 QKDTTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMADRAAAERAC 69
            ::|.| .||||||:..........::|..:|.|.:|.::.|:.||:|||:||||.....|.:|.|
Yeast   238 EQDKT-GKIFVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVC 301

Human    70 KDPNPIIDGRKANVNLAYLGAKPRIMQP-----------------GFAFGVQ------------- 104
            :  |..||.:...:.:.  .|:||.||.                 |..||.|
Yeast   302 Q--NKFIDFKDRKIEIK--RAEPRHMQQKSSNNGGNNGGNNMNRRGGNFGNQGDFNQMYQNPMMG 362

Human   105 ----QLHPAL--------------IQRPFGIPAHYVYPQ-----AFVQPGVVIP 135
                .::|..              :|:..|:....:|.|     |.:.||..:|
Yeast   363 GYNPMMNPQAMTDYYQKMQEYYQQMQKQTGMDYTQMYQQQMQQMAMMMPGFAMP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM24	NP_001137414.1	RRM_RBM24_RBM38_like	11..86	CDD:409818	26/74 (35%)
RBM24	NP_001137414.1	Necessary for interaction with EIF4E. /evidence=ECO:0000269\|PubMed:29358667	175..199
HRP1	NP_014518.1	PABP-1234	<144..463	CDD:130689	46/184 (25%)
		RRM1_Hrp1p	161..236	CDD:409991
		RRM2_Hrp1p	244..321	CDD:409767	27/80 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810