Protein Alignment KIF6 and Klp64D

DIOPT Version :9

• Sequence 1: XP_005248961.1
• Gene: KIF6 / 221458
• HGNCID: 21202
• Length: 842
• Species: Homo sapiens
• Sequence 2: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Alignment Length: 801
• Identity: 221/801 - (27%)
• Similarity: 356/801 - (44%)
• Gaps: 170/801 - (21%)

Human     4 QTIQIFARVKPPVRKH-QQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQD 67
            :.:::..|.:|..:.. ..|..|....:|:..::.::.|...|    |...::|  .|..:||..
  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA----NEPPKTY--YFDNVFDGG 77

Human    68 ANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQ 132
            :||..::.:.|:|:...||.||||||.||||||:|||:|::|..:....:||||...::||..:.
  Fly    78 SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIA 142

Human   133 K-DSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEE 196
            | ..::.:...:||:|||||...|||. :....|||      :.|.||..:.:|:|:.:.....:
  Fly   143 KAKENQKFLVRVSYMEIYNEEVRDLLG-KDVGKSLE------VKERPDIGVFVKDLSGYVVHNAD 200

Human   197 EALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRH---AKLHLVDLAGSERVA 258
            :..|::.||:.||.:..|.|||.|:|||.||:|.:...|.|...|:|   .||.|||||||||.:
  Fly   201 DLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQS 265

Human   259 KTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLS 323
            ||...|..|.||..|||||..|..||.||.:...:|||||||.:|.:|:||||||..|.|.||:|
  Fly   266 KTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATIS 330

Human   324 LEKRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALT 388
            ....|..|:|||.|:|.|...|:|...:|||....| ::..|:||..|:.:            |.
  Fly   331 PADSNYMETISTLRYASRAKNIQNRMHINEEPKDAL-LRHFQEEIARLRKQ------------LE 382

Human   389 EAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDCQ 453
            |.:.|: |:..:|..|:..:|..||...::.                  ||::|:.:..|
  Fly   383 EGDSLE-EEPPSSEEEEDTADDELEAPLEIE------------------LESSTIQAVEK----- 423

Human   454 EPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEE 518
               |.::.|:..|..|:.          |.|.|.:.|:.:..|..:                 :|
  Fly   424 ---KPKKKREKTDAEKEE----------LAKRKNEHQKEIEHAKTE-----------------QE 458

Human   519 GQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFKRDHADSVTIDDNKQILK 583
            ..|.:|.|...:     ||....:||.|  ...:|:.|. |...|:.:.:.::...    ||.|:
  Fly   459 TLRNKLVSLEGK-----ILVGGENLLEK--AQTQELLLE-QSIAELEQHEKSEEAL----KQTLQ 511

Human   584 QRFSEAKALGESINEARSKIGHLKEEITQR--HIQQVALGISENMAVPLMPDQQEEKLRSQLEEE 646
            |:.:|.    ..|.|..|.:......||::  .:.|:.:|:...:|     |||        :|.
  Fly   512 QKATER----IDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELA-----DQQ--------QEH 559

Human   647 KRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQ 711
            :|..:.::..:::|..|:...:|:::.   .:.||::              ..:|...|
  Fly   560 QREKEGIYENIRSLSRELALCELVLNS---YVPKEYQ--------------SMINQYTH------ 601

Human   712 TSDSQHEWSQLLSNKSSGGWEVQDQG-TGRFDVCDVNARKIL---------PSPCPSPH---SQK 763
                   |     |:..|.|:::... ||.      |.||.:         |......|   |..
  Fly   602 -------W-----NEDIGEWQLKCVAYTGN------NMRKHISAHKTSGKEPDFLDLSHVYLSYN 648

Human   764 QSSTSTPLEDSIPKRPVSSIP 784
            ....|.|:.....:...|.:|
  Fly   649 TDGVSNPMRSKSARPRTSGVP 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	135/342 (39%)
		Kinesin	11..345	CDD:278646	135/338 (40%)
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	135/345 (39%)
		Kinesin	26..352	CDD:278646	135/338 (40%)
		RILP-like	<437..556	CDD:304877	32/166 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810