DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF6 and Kif6

DIOPT Version :9

Sequence 1:	XP_005248961.1	Gene:	KIF6 / 221458	HGNCID:	21202	Length:	842	Species:	Homo sapiens
Sequence 2:	NP_796026.2	Gene:	Kif6 / 319991	MGIID:	1098238	Length:	802	Species:	Mus musculus

Alignment Length:	811	Identity:	665/811 - (81%)
Similarity:	712/811 - (87%)	Gaps:	12/811 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFD 65
            ||||||||||||||.|||.|||||||||||||..||||:||||||||||||||||||||||||||
Mouse     1 MVKQTIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLEIVLPRDLADGFVNNKRESYKFKFQRIFD 65

Human    66 QDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQ 130
            |:|.||.:||.||||||.|.|||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 QEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQ 130

Human   131 LQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTE 195
            ||||||||||||||||||||||||||||||||||.||||||||||||||||||||||:|||||||
Mouse   131 LQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTE 195

Human   196 EEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKT 260
            |||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||:||
Mouse   196 EEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRHAKLHLVDLAGSERVSKT 260

Human   261 GVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLE 325
            ||||.|||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse   261 GVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLE 325

Human   326 KRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEA 390
            |||:||||||||||||||||||||:|||||:|||:|.||||||::||.||||.||||||||||||
Mouse   326 KRNIDESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIEDLKAELAMATGEQRTEALTEA 390

Human   391 ELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEP 455
            |||||||||.|:|||||.:|||||||||||:||||||.||||||||.|| |||||||..|.||||
Mouse   391 ELLQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDKKTLE-NTVSSESTRQACQEP 454

Human   456 LKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQ 520
            |::|||.||..:|||||||||||||||||||||.|:||..:.:::.:.|..|:.||..|:|.. .
Mouse   455 LRDEEYTKLLGLLKQRDNEINILVNMLKKEKKKTQDALQNSSLEKSDTRPPQNSPFIAGSPAV-P 518

Human   521 RMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFKRDHADSVTIDDNKQILKQR 585
            |...|||||..||.||...||||||||.|||||||||.|||||||||||||||||:||||:||||
Mouse   519 RTPFSSAPSHTQDLSICRHRSSLLHKKTGMREEMSLGRQEAFEIFKRDHADSVTIEDNKQVLKQR 583

Human   586 FSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPLMPDQQEEKLRSQLEEEKRRY 650
            |||||||||||||||||||.||:.|.|||:||||||||||......||.||||||:||||||.||
Mouse   584 FSEAKALGESINEARSKIGQLKDAINQRHLQQVALGISENTVPASTPDPQEEKLRAQLEEEKGRY 648

Human   651 KTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDS 715
            ||.|..|||||||||||||||||||||||||||.|||||||:|||||||.|..|..|||     .
Mouse   649 KTAFMHLKALKVEIEHLQLLMDKAKVKLQKEFEAWWAEEATSLQVNSPATNLQDAVKPF-----P 708

Human   716 QHEWSQLLSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPV 780
            |.:.:||||.|||...||:: |.||.:|||.|||:|||||||:..||:.|.:...::|    ||:
Mouse   709 QQDQAQLLSKKSSRDLEVEN-GAGRLEVCDRNARRILPSPCPNQQSQEPSGSRVLVQD----RPL 768

Human   781 SSIPLTGDSQTDSDIIAFIKARQSILQKQYL 811
            |||||||||||||||:||||||||||||:.|
Mouse   769 SSIPLTGDSQTDSDILAFIKARQSILQKKCL 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	318/337 (94%)
KIF6	XP_005248961.1	Kinesin	11..345	CDD:278646	314/333 (94%)
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	318/337 (94%)
		Kinesin	11..345	CDD:278646	314/333 (94%)
		Cob_adeno_trans	<350..>408	CDD:294596	47/57 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972075
Domainoid	1	1.000	644	1.000	Domainoid score	I4492
eggNOG	1	0.900	-	-		E2759_KOG0242
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35308
Inparanoid	1	1.050	1282	1.000	Inparanoid score	I3918
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56819
OrthoDB	1	1.010	-	-		D424630at2759
OrthoFinder	1	1.000	-	-		FOG0011058
OrthoInspector	1	1.000	-	-		oto125008
orthoMCL	1	0.900	-	-		OOG6_105680
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8637
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270