DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tub and ktub

DIOPT Version :9

Sequence 1:	NP_068685.1	Gene:	Tub / 22141	MGIID:	2651573	Length:	505	Species:	Mus musculus
Sequence 2:	NP_611549.2	Gene:	ktub / 37400	FlyBaseID:	FBgn0015721	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	224/517 - (43%)
Similarity:	301/517 - (58%)	Gaps:	80/517 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    19 GSNLRQQKLDRQRALLEQKQKKKRQEPLMVQAN--ADGRPRSRRARQSEE----QAPLVESYLSS 77
            |.|.|.||:::||.|:|...::||..|.||||:  ...||.|.....|.|    ..|:  .::||
  Fly     3 GINSRNQKMEQQRQLMEAYIRQKRASPGMVQASDLQINRPMSGMRSNSRELHAYDGPM--QFISS 65

Mouse    78 SGSTSYQVQEADSI-ASVQLGATRPPAPASAKKSKGAAASGGQGGAPRKEKKGKHKGTSGPATLA 141
            .       |..|.| .:...|...|.|..:::..     |..........::||...|...|.|.
  Fly    66 P-------QNPDQILTNGSPGGINPVAMNTSRNH-----SNNMRSLSTINQEGKWSYTPRKADLI 118

Mouse   142 ED------KSEAQGPVQILTVGQSDHDKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEDE 200
            |:      :.|...||.::    ..|.:.|..:|            .:|..:|..:...||.::.
  Fly   119 EEISSHELEDEESSPVTVI----EQHQQSASHSA------------NSTQSQKPRARQHSFSDNL 167

Mouse   201 DEDENSSSSSQLNSNTRPSSATSRKSIREAASAPSP----------------AAPEPPVDIEVQD 249
            |||:.:      |.|...::     .:|.|..|.||                ...|...|: :.:
  Fly   168 DEDDYT------NRNVAGAA-----PVRPAGMASSPYKDATLDGSSNGTGNGTGGESEGDV-IGN 220

Mouse   250 LEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLIS 314
            :::|.::|||||:..|||||||:||||||::|.|:|||:|:.|||:|||.||||||||||||::|
  Fly   221 IDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVS 285

Mouse   315 VDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFK 379
            .|||||||..|.:.||||||:.||.|||:||| |.:...|.       |.:||.:.|:||:||||
  Fly   286 CDPTDLSRNADGFCGKLRSNVFGTSFTVFDNG-NKESTESP-------RLDLAVIIYDTNILGFK 342

Mouse   380 GPRKMSVIVPGMNMVHERVCIRPRN-EHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFH 443
            |||.|:||:|||....:||.|...: :.:.:|..|:.||.::|:||.||||||||:|||||||||
  Fly   343 GPRNMTVILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFH 407

Mouse   444 GRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE 505
            ||||||||||||::|.:||:||||||||.:||||||||.|||||:|||||||||||.|:|||
  Fly   408 GRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tub	NP_068685.1	Tub_N	29..226	CDD:292938	47/209 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..243		50/236 (21%)
		Tub	257..498	CDD:279506	157/241 (65%)
ktub	NP_611549.2	Tub	228..462	CDD:279506	157/241 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1129
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2122
Isobase	1	0.950	-	0	Normalized mean entropy	S3334
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm43871
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	LDO	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2866
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810