DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCGR3A and him-4

DIOPT Version :9

Sequence 1:	NP_001121064.2	Gene:	FCGR3A / 2214	HGNCID:	3619	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	346	Identity:	73/346 - (21%)
Similarity:	122/346 - (35%)	Gaps:	93/346 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    15 DAQPQTFEGVKGADPPTLPPGSFLPGPVLWWGSLARLQTEKSDEVS-RKGNWWVTEMGGGAGERL 78
            ::.|:.| ||:....| |...:||           ...|..:.||. |...:..|...|...||.
Worm   518 ESPPEIF-GVRNVSVP-LGEAAFL-----------HCSTRSAGEVEIRWTRYGATVFNGPNTERN 569

Human    79 FTSSCLVGLVPLGLRISLVTCPLQCGIMWQLLLPTALLLLVSAGMRTDLPKAVVFLEPQWYRVLE 143
            .|:..        |:|..|| ....|: ::.:...|      .||.|...:..: :||...:|..
Worm   570 PTNGT--------LKIHHVT-RADAGV-YECMARNA------GGMSTRKMRLDI-MEPPSVKVTP 617

Human   144 KD-------SVTLKCQGAYSPEDNSTQWFHNESLIS------SQASSY-FIDAATVDDSGEYRCQ 194
            :|       .|.|.|:....|:.....:|....|::      .|.|.: :|..||..|.|.|.|:
Worm   618 QDVYFNMREGVNLSCEAMGDPKPEVHWYFKGRHLLNDYKYQVGQDSKFLYIRDATHHDEGTYECR 682

Human   195 -----------TNLSTLSDP----VQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVT 244
                       |:|...:.|    :|.::.:|            ..|.:...|.:.:.....|:.
Worm   683 AMSQAGQARDTTDLMLATPPKVEIIQNKMMVG------------RGDRVSFECKTIRGKPHPKIR 735

Human   245 YLQNGKG----RKYFHHN-SDFYIPKATLKDSGSYFCRG-LFGSKNV---------------SSE 288
            :.:|||.    ..|...| ...:|..|..:|:|:|.|.| ....|:|               |..
Worm   736 WFKNGKDLIKPDDYIKINEGQLHIMGAKDEDAGAYSCVGENMAGKDVQVANLSVGRVPTIIESPH 800

Human   289 TVNITITQGLAVSTISSFFPP 309
            ||.:.|.:.:.:..::...||
Worm   801 TVRVNIERQVTLQCLAVGIPP 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCGR3A	NP_001121064.2	None
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652	22/105 (21%)
		Ig	628..694	CDD:319273	15/65 (23%)
		I-set	702..789	CDD:369462	20/98 (20%)
		I-set	793..881	CDD:369462	6/29 (21%)
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229
		IGc2	1563..1628	CDD:197706
		Ig	1651..1732	CDD:386229
		Ig	1755..1818	CDD:319273
		Ig	1839..1912	CDD:386229
		Ig	1930..2002	CDD:386229
		IG_like	2014..2095	CDD:214653
		Ig	2094..2182	CDD:386229
		Ig	2190..2283	CDD:386229
		I-set	2296..2380	CDD:369462
		Ig	2384..2471	CDD:386229
		IGc2	2492..2556	CDD:197706
		Ig	2580..2654	CDD:386229
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653
		I-set	3046..3116	CDD:369462
		I-set	3127..3213	CDD:369462
		Ig	3217..3292	CDD:386229
		I-set	3300..3386	CDD:369462
		I-set	3396..3472	CDD:369462
		I-set	3481..3569	CDD:369462
		I-set	3591..3663	CDD:369462
		Ig	3667..3762	CDD:386229
		Ig	3775..3848	CDD:386229
		Ig	3859..3947	CDD:386229
		IGc2	3968..4031	CDD:197706
		Ig_3	4045..4119	CDD:372822
		Ig_3	4136..4210	CDD:372822
		Ig	<4262..4314	CDD:386229
		Ig	4318..4406	CDD:386229
		IG_like	4418..4496	CDD:214653
		I-set	4570..4654	CDD:369462
		I-set	4752..4836	CDD:369462
		EGF_CA	4996..5027	CDD:238011
		EGF_CA	5034..5076	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910