DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRF5 and lat-2

DIOPT Version :9

Sequence 1:	XP_005248949.1	Gene:	ADGRF5 / 221395	HGNCID:	19030	Length:	1386	Species:	Homo sapiens
Sequence 2:	NP_001040724.1	Gene:	lat-2 / 173771	WormBaseID:	WBGene00002252	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	1265	Identity:	260/1265 - (20%)
Similarity:	439/1265 - (34%)	Gaps:	364/1265 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   301 NVSWRYEEQQLEIQNSSRFSIYTALFNNMTSVSKLTIHNITPGDAGEYVCKLILDIFEYECKKKI 365
            |:...|.:..:.:|:.|.:..:|..   :.::.|.|            |||
Worm   158 NIYVNYNDVCVALQSDSFYREWTTA---LCTILKYT------------VCK-------------- 193

Human   366 DVMPIQILANEEMKVMCDNNPVSLNCCSQGNVNWSKVEWKQEG----KINIPGTPETDID----- 421
             |.|.||.|....:..|.|......|.:|...|......:..|    :.:.|......:|
Worm   194 -VAPTQIQAKYVAQCSCPNGYGGQTCETQSTTNQQASTQRTCGSNDFQFSCPNDQTITVDFASFG 257

Human   422 ----SSCSRYTLKADGTQCPSGSSGTTVIYTCEFISAYGARGSANIKVTFISVGDNSSHKSEVHE 482
                |.|::.:...:.| |.:.:|..|||..|:.:.:...|   |:..||    .|:.......:
Worm   258 AQESSMCNQASQSREQT-CSNVNSLQTVINACQGLQSCEIR---NLTSTF----SNTPCPVPQEQ 314

Human   483 VLRHVMEMSTVQSTTRNSLETSKAQEQQANLTITPDPISVSEGQNFSIKCISDVSNYDE------ 541
            .|...|...|.|                       .|..:|....|..:|.|.....:|
Worm   315 YLETRMRCETAQ-----------------------QPSCLSGLIQFDSRCYSMTIETNEKKQRTM 356

Human   542 ----VYWNTSAGI-----------KIYQRFYTTRRYLDGAESVLTVKTSTREWNGT-YHC----I 586
                .|.:.|.|.           :|.|:.        .||:..||..    |.|| .:|    :
Worm   357 EDAQTYCSQSGGSIITSPPDALLQQIVQKV--------NAETKKTVNF----WIGTPNNCQLLMV 409

Human   587 FRYKNSYS------IATKDVIVHPLPLKL---------NIMVDPLEATVSCSGSHHIKCCIEEDG 636
            .....|||      .:|.:||...:|...         :..|||:..|::
Worm   410 TGSSTSYSQCPSSPSSTANVICSTVPQSTASVSARPTQSAPVDPVSQTMA--------------- 459

Human   637 DYKVTFHTGSSSLPAAKEVNKKQVCYKHNFNASSVSWCSKTVDVCCHFTNAANNSVWSPSMKLNL 701
              :...:||.........:||.:.|.|..
Worm   460 --RREVYTGVQPPSVPDSINKPRYCKKEK------------------------------------ 486

Human   702 VPGENITCQDPVIGVGEPGKVIQKLCRFSNVPSSPESPIGGTIT--YKCVGSQWE-EKRNDCI-- 761
              .:.||.:.            .:.|.....|......:.||:|  ..|..::|| ....:|.
Worm   487 --KDGITYEQ------------TRACMLHEQPCPDPQNVEGTVTRYCNCQTAKWETPDTTNCTHR 537

Human   762 -----------SAPINSLLQMAKALIKSPSQ---------------DEMLP------TYLKDLSI 794
                       :.|:..:.......:||..:               ::||.      :.|.|.::
Worm   538 WVAEMETAIKDNQPVEDISSTVNRQLKSTIERTLFGGDITGTVRLSNDMLSLARNQFSVLNDRNL 602

Human   795 SIDKAEHEISSSPGSLGAIINIL------DLLSTVPTQVNSEMMTHVLSTVNVILGKPVLNTWKV 853
            ..:||.:...:..||...:::.:      .|.||:..|..|::|: ||....::||..:  |.:.
Worm   603 RENKARNFTENLGGSGDQLLSPVAATVWDQLSSTIRIQHASKLMS-VLEQSVLLLGDYM--TDQK 664

Human   854 LQQQWTNQSSQLLHSVERFSQALQ---SGDSPPLSFSQTNVQMSSMVIKSSHPETYQQRFVFPYF 915
            |..|:.|.:.:    |||....:|   :..||.:......:::.:....:..||| ....:||..
Worm   665 LNLQYINWAME----VERSEPEVQTFGAAASPNVQDDMGMMRVMAAAPPAPQPET-NTTIMFPSL 724

Human   916 DLWGNVVIDK------------------SYLENLQSDSSIVTMAFPTLQ-----------AILAQ 951
            .|...:.:..                  |.|.:.|.|:.:...:.|.|.           |...|
Worm   725 KLSPTITLPSASLLSSLASPTPVAGGGPSILSSFQDDTPVGMASTPNLNRNPVKLGYYAFAGFGQ 789

Human   952 DIQENN---FAESLVMTTTVSHNT---TMP--FRISMTFKNNSPSG-GETKCVFWNFRLANNTGG 1007
            .:..||   ...|.|:..::.:.|   |:|  ..::.||::.:..| ...:||:|:...:.
Worm   790 LLNNNNDHTLINSQVIGASIQNATQSVTLPVDHPVTFTFQHLTTKGVSNPRCVYWDLMESK---- 850

Human  1008 WDSSGCYVEEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGIL-------LDIISYVGVGFSIL 1065
            |.:.||.:.....::..|.|.|||||:|||     |.|..:|.|       ||::|.:|...||:
Worm   851 WSTLGCTLIATSSNSSQCSCTHLTSFAILM-----DISGQVGRLSGGLASALDVVSTIGCAISIV 910

Human  1066 SLAACLVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVAAT 1130
            .||..:.| ...::::...|.|..|:.|:     .||:|...|::......||     |.|....
Worm   911 CLALSVCV-FTFFRNLQNVRNSIHRNLCL-----CLLIAELVFVIGMDRTGNR-----TGCGVVA 964

Human  1131 FFIHFFYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCLGYGCPLAISVITLGATQPREV 1195
            ..:|:|:||.|.|||..|..|:..|:.:.............||  ||.|..:..|:.|...  |.
Worm   965 ILLHYFFLSSFCWMLLEGYQLYMMLIQVFEPNRTRIFLYYLFC--YGTPAVVVAISAGIKW--ED 1025

Human  1196 YTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILRPSIGDKPCKQEKSSLFQISKS 1260
            |...:.||:: ..|..:.||..|.::|:..||...::.:..:|.....|   :.:...:....|.
Worm  1026 YGTDSYCWID-TSTPTIWAFVAPIIVIIAANIIFLLIALKVVLSVQSRD---RTKWGRIIGWLKG 1086

Human  1261 IGVLTPLLGLTWGFG-LTTVFPGTNLVFHIIFAILNVFQGLFILLFGCLWDLKVQEALLNKFSLS 1324
            ...|..|||:||.|| ||.|..||...|..||.|||..||:||.:...:.:.||      :.|:.
Worm  1087 SATLLCLLGITWIFGFLTAVKGGTGTAFAWIFTILNCTQGIFIFVLHVVLNEKV------RASIV 1145

Human  1325 RW------------SSQHSKSTSLGSSTPVFSM--------------------SSPISRRFNNLF 1357
            ||            |:.::..:.|.|...:.:|                    .:||::..:.|.
Worm  1146 RWLRTGICCLPETSSAAYNSRSFLSSRQRILNMIKVNGHSYPSTASTDDKEKQLTPITKTTDWLS 1210

Human  1358 GKTGTYNVSTPEAT----SSSLENSSSASS 1383
            ......:||.||:.    :.:||||:..|:
Worm  1211 RLPNQDSVSIPESNFNNLNGTLENSNLNSA 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRF5	XP_005248949.1	SEA	170..259	CDD:279699
		IG_like	285..361	CDD:214653	10/59 (17%)
		IGc2	285..351	CDD:197706	8/49 (16%)
		IG_like	517..602	CDD:214653	24/116 (21%)
		GPS	994..1036	CDD:280071	13/41 (32%)
		7tm_4	1051..1302	CDD:304433	75/258 (29%)
		7tm_1	1070..1308	CDD:278431	68/238 (29%)
lat-2	NP_001040724.1	CLECT	52..193	CDD:214480	8/49 (16%)
		Gal_Lectin	242..322	CDD:280328	18/87 (21%)
		CLECT	330..>399	CDD:295302	15/80 (19%)
		HormR	479..542	CDD:214468	13/112 (12%)
		GAIN	556..>660	CDD:293098	20/104 (19%)
		GPS	837..884	CDD:197639	17/55 (31%)
		7tm_4	894..1129	CDD:304433	74/253 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910