DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRF5 and adgrf8

DIOPT Version :9

Sequence 1:	XP_005248949.1	Gene:	ADGRF5 / 221395	HGNCID:	19030	Length:	1386	Species:	Homo sapiens
Sequence 2:	XP_021324214.1	Gene:	adgrf8 / 100537224	ZFINID:	ZDB-GENE-130531-41	Length:	1719	Species:	Danio rerio

Alignment Length:	1642	Identity:	405/1642 - (24%)
Similarity:	618/1642 - (37%)	Gaps:	459/1642 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    55 TKSPTAEE---YTVNIEISFENASFLDPIKAYLNSLSFPIHGNNTDQITDILSINVTTVCRPAGN 116
            |:|.||..   |...|:||..:.|..:.:::.:.|...|....:    .:||.:|:||||...|.
Zfish   217 TQSTTAGPLFVYESEIDISLFDISSANRLESLITSYQPPYSLGS----MNILELNITTVCGLNGT 277

Human   117 EIWCSCETGYGWPRERCLHNLICQERDVFLPGHHCSCLKELPPNGPFCLLQEDVT---------- 171
            |..|.|...:.|....|.....|..    :.|..|.|::.||..||.|  |.|:.
Zfish   278 EYDCQCAANHVWSSNNCTTYQACDN----IVGGTCGCIRALPSAGPLC--QRDINECQPSPSVCG 336

Human   172 ------------------------LNMRVRLNVGFQEDLMNTSSALYRSYKTDLETAFRKGYGIL 212
                                    .|:.|.:|...:|.|.:.::....:..:.|.|
Zfish   337 PNSSCTNEIGSYSCACLNGFTPTIFNLSVSMNNTCRESLTSPTTTPATTPTSTLTT--------- 392

Human   213 PGFKGVTVTGFKSGSVVVTYEVKTTPPSLELIHKANEQVVQSLNQTYKMDYNSFQAVTINESNFF 277
                 ...|...|.|..|...|..:...::|........::.|..|    .|||...|:|..|..
Zfish   393 -----TPTTRPLSSSTTVPLFVYDSEIEIDLFFDYPTSSIRDLFTT----VNSFLPYTLNNVNLL 448

Human   278 ---VTPEIIFEGDTVSLVCE-KEVLSSNVSWRYE-----------------------EQQL-EIQ 314
               :|......|......|| ..|..||....|:                       :|.: |.|
Zfish   449 SVDMTTVCDLNGTDFDCKCEVAHVWPSNTCKAYQVCDNIVGGTCGCIQALPSNGTLCQQDINECQ 513

Human   315 --------NSSRFSIYTALF-------------------NNMTSVSKLTIHNITPGDAGEYVCKL 352
                    ||:..::..:.:                   |...:.:.||....||....
Zfish   514 QTPSVCGPNSTCTNVIGSYYCLCLPGFIPANPNLLASINNTCIATAPLTPTPSTPTTKA------ 572

Human   353 ILDIFEYECKKKIDVM---PIQILAN------------------EEMKVMCDNNPVSLNCCSQGN 396
              .:|.||...:||:.   |:..|.|                  ..:..:||.|....:|..:.|
Zfish   573 --PVFVYESDIEIDLFSDYPMSSLRNLLTGIPLPYTLSIINLLSVNITTVCDLNGTGFDCKCEAN 635

Human   397 VNWSKVEWKQEGKINIPGTPETDIDSSCSRY---------------TLKADGTQC--------PS 438
            ..|.                    .|:|:.|               ||.::|:.|        ||
Zfish   636 HVWP--------------------SSTCTTYQVCDSIVGGTCGCIQTLPSNGSLCQQDINECQPS 680

Human   439 GS-SGTTVI-------YTCEFISAYGARG-----SANIKVTFISVGDNSSHKSEVHEVLRHVMEM 490
            .| .|...|       |:|..::.:....     |:|.|.|..:.....|.:.......:...:
Zfish   681 PSVCGPNSICNNEIGSYSCSCLNGFTPANSNLLVSSNNKCTAPTTTPQPSPQPSPQPSTQPTPQ- 744

Human   491 STVQSTTRNSLETSKAQEQQANLTITPDP--------------------ISVSEGQNF------- 528
            :|.|:||  ..:.:....|....|.||:|                    :|:...|.|
Zfish   745 TTPQTTT--PPQPTPTTPQPTTTTTTPEPTTTTTTTTTTTTTVATKVITMSLKMDQTFDTNLADS 807

Human   529 SIKCISDV-----SNYDEVYWNTSAGIKIY----------------------------------- 553
            :.:...|:     |:.|..|   |:.:|.|
Zfish   808 TTQTFKDLSGKLESSIDSSY---SSNLKGYVSKSVKVNAYRPGSVFADYTISATSSNLDFSSANA 869

Human   554 -----------------------QRFYTTRRY--------------------------------- 562
                                   :.|.|.:.|
Zfish   870 ALSSSLQAQGIILAADAFAQSDQKDFITGQVYPQQKLELICTQPDFAQGQITWKVNNKDPDKNQY 934

Human   563 -LDGAESVLTVKTSTREWNGTYHCIFRYKNSYSIATKDVIVHPLPLKLNIMVDPLEATVSCSGSH 626
             |......||..:.|...:|.|.||.:......|..:::.|..||   ||.|......|.|.||.
Zfish   935 SLSSDNRTLTANSVTESNSGQYSCITQRTTIPYIQWQNIAVKQLP---NINVGNNYRVVQCPGSS 996

Human   627 HIKCCIEEDGDYKVTFHTGSS---SLPAAKEVNKKQVCYKHNFNASSVSWCSKTVDVCCHFTNAA 688
            .:||.:  |..|.:.:..|.:   |..||..:..       |: ||.:..|::.....|......
Zfish   997 VLKCSV--DAGYSIEWVQGETVQVSESAADGITL-------NY-ASQIGNCTQEQTFTCRLKGLP 1051

Human   689 NNSVWSPSMKLNLVPG--ENITCQDPVIGVGEPGKVIQKLCRFSNVPSSPESPIG--GTITYKCV 749
            ...::..|....:|..  :...||:..:|:|...:....:|           |.|  |.|||:|.
Zfish  1052 ALLIYGYSQSSVIVKNTDQQYDCQNEELGLGNQNEQRNGIC-----------PTGTKGIITYECD 1105

Human   750 GSQWEEKRNDCISAPINSLLQMAKALIKSPSQDEMLPTYLKDLSISIDKAEHEISSSPGSLGAII 814
            ...|...:.:||...|:.||.....|     |...:|::|.:||.:.::....|:.|..::.||:
Zfish  1106 SKAWRPIKENCILGVISDLLTQIPVL-----QVGQIPSFLSNLSFATEQNNINITQSAATVKAIV 1165

Human   815 NILDLLSTV--PTQVNSEMMTHVLSTVNVILGKPVLNTWKVLQQQWT--NQSSQLLHSVERFSQA 875
            :||..::.:  ...:...:|...|.|:::|:......||..|....|  |.:.:||.:.|..|..
Zfish  1166 DILSQIANLAQTALIGPPVMNSFLKTLDIIVSTNSTETWNTLNNDNTTENTNIKLLKATETISDR 1230

Human   876 LQSGDSPPLSFSQTNVQMSSMVIKSSHPETYQQRFVFPYFDLWGNVVIDKSYLENLQSDSSIVTM 940
            |    ....:.:.|::|:|...:.||...|                    |.|.|..::..|..:
Zfish  1231 L----IDQFTVNLTSIQLSRTTVNSSLSVT--------------------STLSNSTTEIVIPQV 1271

Human   941 AFPTLQAILAQDIQENNFAESLVMTTTVSHNTTMPF-------------------RISMTFKNNS 986
            ..||...|:.....:|     ::.|..:|:|.:...                   .||..|...:
Zfish  1272 FGPTTATIIIFTTLDN-----ILPTRNISNNNSSDISDQRINGDVVVVKVDKTVNNISFAFDITN 1331

Human   987 PSGGETKCVFWNFRLANNTGGWDSSGCYVEEGDGDN--VTCICDHLTSFSILMSPDSPDPSSLLG 1049
            .|.|..:||||||    |...|||:||.|::...|:  :||.|:|.|||||||||...|     .
Zfish  1332 QSLGNPQCVFWNF----NLSAWDSTGCEVKQVGNDSGIITCECNHTTSFSILMSPFILD-----S 1387

Human  1050 ILLDIISYVGVGFSILSLAACLVVEAVVWKSVTKNR-----TSYMRHTCIVNIAASLLVANTWFI 1109
            ::|..|:|:||..|::||..||::||:||:|||..|     :|||||..:||||.|||:||..||
Zfish  1388 LILAYITYIGVTISMISLVLCLIIEAIVWRSVTSARGVTVVSSYMRHISLVNIALSLLIANVCFI 1452

Human  1110 VVAAIQDNRYILCKTACVAATFFIHFFYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCL 1174
            :.|||.|.........|....||||||||:||||||..|::|.|..|.:..:.||....||:|.:
Zfish  1453 IGAAISDLEKPTPVGRCSPVVFFIHFFYLAVFFWMLISGMLLLYMTVMVFGQMSRIKMIAISFPV 1517

Human  1175 GYGCPLAISVITLGATQPREVYTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILR 1239
            |||.||.|:.||:.:|...:.|..|..|||||.:::|||||.||||.||.:|:.:.:||:.|:|.
Zfish  1518 GYGAPLLIASITVASTAGPQNYVSKQACWLNWNESRALLAFVIPALTIVAINLVVLVVVLYKMLG 1582

Human  1240 PSIGDKPCKQEKSSLFQISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFILL 1304
            ..:|......||::.|.:.:.:..||||.|||||||:.|:. .:.|..|::|.:||.|||.||||
Zfish  1583 TGVGAATQPSEKNTFFVVVRCVAFLTPLFGLTWGFGIGTML-SSALGVHVLFTLLNAFQGFFILL 1646

Human  1305 FGCLWDLKVQEALLNKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTG----TYNV 1365
            ||.:.|.||:|||..|..:.:.:|:.::|||.|:|:..               |:.|    .|||
Zfish  1647 FGTILDAKVREALRGKLQIDKLASRITQSTSGGASSSA---------------GQRGPRRNVYNV 1696

Human  1366 STPEATSSSLENSSSAS 1382
            |.|..||.......|.|
Zfish  1697 SDPNNTSRFTSEGVSGS 1713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRF5	XP_005248949.1	SEA	170..259	CDD:279699	14/122 (11%)
		IG_like	285..361	CDD:214653	19/127 (15%)
		IGc2	285..351	CDD:197706	17/117 (15%)
		IG_like	517..602	CDD:214653	24/208 (12%)
		GPS	994..1036	CDD:280071	22/43 (51%)
		7tm_4	1051..1302	CDD:304433	118/255 (46%)
		7tm_1	1070..1308	CDD:278431	116/242 (48%)
adgrf8	XP_021324214.1	EGF_CA	156..189	CDD:214542
		EGF_CA	324..357	CDD:214542	1/32 (3%)
		EGF_CA	508..>540	CDD:214542	4/31 (13%)
		EGF_CA	673..706	CDD:214542	7/32 (22%)
		Ig	899..968	CDD:325142	9/68 (13%)
		GPS	1337..1379	CDD:307782	22/45 (49%)
		7tm_GPCRs	1387..1660	CDD:333717	129/273 (47%)
		TM helix 1	1390..1414	CDD:320095	11/23 (48%)
		TM helix 2	1434..1455	CDD:320095	12/20 (60%)
		TM helix 3	1470..1492	CDD:320095	14/21 (67%)
		TM helix 4	1513..1529	CDD:320095	8/15 (53%)
		TM helix 5	1551..1574	CDD:320095	12/22 (55%)
		TM helix 6	1598..1623	CDD:320095	13/24 (54%)
		TM helix 7	1627..1652	CDD:320095	14/24 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I8663
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I7178
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210141at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26837
orthoMCL	1	0.900	-	-		OOG6_112672
Panther	1	1.100	-	-	O	PTHR45813
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3840
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.870