DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRF4 and adgrf1

DIOPT Version :9

Sequence 1:	NP_001334784.1	Gene:	ADGRF4 / 221393	HGNCID:	19011	Length:	695	Species:	Homo sapiens
Sequence 2:	NP_001107298.1	Gene:	adgrf1 / 100135087	XenbaseID:	XB-GENE-6468452	Length:	1304	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	258/711 - (36%)
Similarity:	381/711 - (53%)	Gaps:	98/711 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    11 CCLVFFLSTECSHY-----------------------RSKIHLKAGDKLQSPEGKPKTGRIQEKC 52
            |..|.:....|.:|                       |.::.:|.|       ..|..|.:.:..
Frog   606 CFNVTYNCANCGNYTASCTITNSLGGTVKSAPMKLTLRQQVEIKCG-------APPGVGALGDII 663

Human    53 EGPCISSSNCSQPCAKDFHGEIGFTCNQKKWQKSA-ETCTSLSVEKLFKD---STGASRLSVAAP 113
            ..|| ||.|.      :..|...:||....||... :.|....:.:|..|   .||..    .|.
Frog   664 TVPC-SSENI------NLTGNKSYTCTSTGWQAVVPDNCVLQVLNRLVSDVPSLTGPG----GAE 717

Human   114 SIPLHILDFRAPETIESVAQGIRKNCPFDYACITDMVKSSETTS-GNIAFIVELLKNISTDLSDN 177
            .:|:::.:..|..|.|                     |.:.|:| .||..:|.:|:.::| .:..
Frog   718 ILPVYVANLSATVTAE---------------------KENITSSPSNIVTVVNILQQVTT-TTQT 760

Human   178 VTREKMKSYSEVANHILDTAAISNWAFIPNK-NASSDLLQSVNLFARQLHIHNNSENIVNELFIQ 241
            |..:.|:::....|.::|..:.:.|..:.|: :..:.||.||..|||:|.|.|.|.:|:|...:|
Frog   761 VQPDVMQNFLTTVNVVVDDTSKNAWNNMNNRTDRGTQLLNSVEQFARKLQIDNGSISIINNSNVQ 825

Human   242 TKGFHINHNTS-EKSLNFSMSMNNTTEDILGMVQIPRQELRKLWPNASQAISIAFPTLGAILREA 305
            ..|...|.:.| .:|.|||.. ||.|    |.|.|.:..:..: .|.:..|:||:.||..|
Frog   826 LAGIIANSSRSYNESFNFSQG-NNLT----GSVLISKDSVSNM-ENNTNIITIAYATLKDI---- 880

Human   306 HLQNVSLPRQVNGLVLSVVLPERLQ---EIILTFEKINKTRNARAQCVGWHSKKRRWDEKACQMM 367
             |.|.| .:.|||||::.||..::.   :|.:.|:|.|:|.|... ||.|:.:...||...||.:
Frog   881 -LLNTS-TKVVNGLVMTTVLSTQVPSNFKISMNFKKSNQTLNVPG-CVFWNLETNNWDSTGCQGV 942

Human   368 LDIRNEVKCRCNYTSVVMSFSILMSSKSMTDKVLDYITCIGLSVSILSLVLCLIIEATVWSRVVV 432
            .:..| |.|.|::   :.|||||||.|::...||||||.|||::||:||::|:.||..:|..|..
Frog   943 NNAEN-VSCDCDH---LTSFSILMSYKAVDSIVLDYITYIGLAISIISLLICITIEGLIWKSVTK 1003

Human   433 TEISYMRHVCIVNIAVSLLTANVWFIIGSHFN-------IKAQDYNMCVAVTFFSHFFYLSLFFW 490
            .:.|||||||:||||||||.|::||||||..:       :...:.|.||:.|||:||||||||||
Frog  1004 NKTSYMRHVCLVNIAVSLLIADIWFIIGSAISTLLKSDPLNTANSNACVSATFFTHFFYLSLFFW 1068

Human   491 MLFKALLIIYGILVIFRRMMKSRMMVIGFAIGYGCPLIIAVTTVAITEPEKGYMRPEACWLNWDN 555
            ||...|::.|.::.:...|.|||||.|.|.:||||||:|::.|||:|:|.:.|:...|||||:.:
Frog  1069 MLTMGLILFYRLVYVLHDMSKSRMMAIAFTMGYGCPLLISIITVAVTQPGRTYLNGNACWLNFSD 1133

Human   556 TKALLAFAIPAFVIVAVNLIVVLVVAVNTQRPSIGSS-KSQDVVIIMRISKNVAILTPLLGLTWG 619
            :||.:||.:||..|:.||.|::.||.:...|||:|.. |.:|...::.|.|::||||||||||||
Frog  1134 SKAFIAFVLPALTIILVNFIILAVVIIKLLRPSVGDKPKKEDKSTLIHIGKSIAILTPLLGLTWG 1198

Human   620 FGIATLIEGTSLTFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRMSSLKGKSRAAENA 680
            |||||:|...:|....|||.||:.||.||||||.::|.|:||:|..|.|..:..|:..:::
Frog  1199 FGIATIIAPDALWVLGIFAALNSLQGLFILLFGCLLDKKVRDSLLSRFSLSRWSSQQTKSS 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRF4	NP_001334784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..695		1/7 (14%)
adgrf1	NP_001107298.1	SEA	169..>232	CDD:279699
		IG_like	277..359	CDD:214653
		ig	277..357	CDD:278476
		GAIN	723..>806	CDD:293098	21/104 (20%)
		GPS	924..961	CDD:280071	14/40 (35%)
		7tm_4	1010..1227	CDD:304433	111/216 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210141at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010