Protein Alignment Ttk and Mps1

DIOPT Version :10

• Sequence 1: XP_006511121.1
• Gene: Ttk / 22137
• MGIID: 1194921
• Length: 869
• Species: Mus musculus
• Sequence 2: NP_001262677.1
• Gene: Mps1 / 42126
• FlyBaseID: FBgn0000063
• Length: 672
• Species: Drosophila melanogaster
• Alignment Length: 672
• Identity: 192/672 - (28%)
• Similarity: 290/672 - (43%)
• Gaps: 151/672 - (22%)

Mouse   149 RLAELKAIQEPDDARDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSE------QLLHKAVETG 207
            |..::.|:....|:.|.|             :..:...:.:.|..|:..      |...|..|..
  Fly     8 RTKDMMALGLDSDSEDDF-------------NTPYRPRQAAAGERKQQPVASFQVQTRGKENEPH 59

Mouse   208 AVPLQMLETAMRNLHLQKKQLLPEEDKKS--------VSASTVLSAQEPFSSSLGNVQNR----- 259
            .:|:.||...:..|.:.... ..|||.||        ::.|.|||..:..::|..|:..|
  Fly    60 PLPINMLPRRVSELTMMDSD-SDEEDIKSNHNLNCAILNDSFVLSPSQELTNSNSNITTRRTPSA 123

Mouse   260 -------------------SISCESRGQAGAARVLYGENLPPQDAEVRHQNPFKQTHAAKRSCP- 304
                               .|:|.|:|...|                   |..||  .||::.|
  Fly   124 APLKQSDSNLSFLGRFNDMGINCSSQGSPVA-------------------NSEKQ--VAKKTAPT 167

Mouse   305 FGRVPVNLLNSPDFYVKTDSSAVTQLTTRKGSGPDRDAILPGSRPRGSDSYELRGLKPIQTIYLK 369
            ....|......|  ..:|::....:|.:...:.||.|.|.|..|..|
  Fly   168 LQAAPSATERRP--LQETETPLRNELPSTSKTKPDADFITPQVRTIG------------------ 212

Mouse   370 DSLVSNEKSSELMSDLIALKSKTDSSLTKLEETKPEIAERRPMQWQSTRKPECVFQNPAAFAPLR 434
             |.::.:..|.:.:|..|.|        .|.:|...::...|:...|.....|        ..:.
  Fly   213 -STLAGKSRSAVSNDFRAQK--------VLFQTPMTVSRAAPVASDSISFSLC--------DTIT 260

Mouse   435 HVPDVTPKADKEQSPPISVPKWLDPKSACETPSSSSLDDYMKCFKTPVVKNDFPPACPSSTPYSQ 499
            ..||: |:..|:..||.|           :.||..|||...:    ...|::.|....:..| .:
  Fly   261 ESPDI-PEPPKKAEPPKS-----------QHPSKKSLDHVFR----ESDKDNVPDKVDNVEP-KE 308

Mouse   500 LARLQQQQQQGLSTPLQSLQISGSSSINECISVNGRIYSILKQIGSGGSSKVFQV-LNEKKQINA 563
            |..:     ..::.|.:    ..|...:..:.:....|:|.|::|.||||.||.. .::.....|
  Fly   309 LVSI-----PAVAVPPE----QPSHKTSNILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFA 364

Mouse   564 IKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEIT--EQYIYMVMECGNIDLNSWLK 626
            :|.|:|: ||.|.::.|.||...|.|||.:. .::.||||::.  |..:|||||.|:.|||..|:
  Fly   365 LKVVDLQ-ADPQVVQGYLNETKLLAKLQGNV-CVVALYDYQLVREESKLYMVMEKGDCDLNKILQ 427

Mouse   627 KKKSINP-WERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSI 690
            ...:..| :...:....||:||:.|||||::|||||||||::|.|.|||||||||:.:..|:|||
  Fly   428 SYTTNLPLYSLMNILYQMLQAVNYIHQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSI 492

Mouse   691 VKDSQVGTVNYMAPEAIRDMSSSRENSKIR------TKVSPRSDVWSLGCILYYMTYGRTPFQHI 749
            :|.||.||.||::|||:.|.|:.  ||.:|      .|:|.:|||||||||||.:.|.:|||.||
  Fly   493 IKFSQAGTFNYISPEALTDTSTG--NSPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHI 555

Mouse   750 INQVSKLHAIINPAHEIEFPEI 771
            .|..:|:.||..|...||:|.|
  Fly   556 RNVYAKMSAITTPGTSIEYPAI 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ttk	XP_006511121.1	LapB	<97..>205	CDD:442196	9/61 (15%)
		TPR repeat	143..172	CDD:276809	5/22 (23%)
		TPR repeat	177..205	CDD:276809	4/33 (12%)
		PKc_Mps1	535..803	CDD:271033	116/247 (47%)
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	116/247 (47%)