DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCGR2B and ed

DIOPT Version :9

Sequence 1:	XP_024309811.1	Gene:	FCGR2B / 2213	HGNCID:	3618	Length:	324	Species:	Homo sapiens
Sequence 2:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	74/383 - (19%)
Similarity:	118/383 - (30%)	Gaps:	140/383 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    47 PPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNND---- 107
            ||..|  :|.:.....:.|:||:.|..|.:|...:|:|....:       |.:|:   |.|
  Fly   337 PPMVV--IESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENS-------PDFRY---NGDVLTL 389

Human   108 -------SGEYTCQTGQTSLSDPVHLT--VLSEWLVLQTPHLEFQE-----------GETIVLRC 152
                   :|.|.|:......|..:..:  |.:..:.|...|...|.           |..:.|.|
  Fly   390 TSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTC 454

Human   153 HS----WKDKPLVKVTFFQN-----GKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSK 208
            .:    |   |:.:..:|::     ..::|.....|.:|||:|:..:.|.|||
  Fly   455 SANPPGW---PVPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHC------------ 504

Human   209 PVTITVQAPSSSPMGIIVAVVTGI------------AVAAIVAAVVALIYCRKKRISALPGYPEC 261
                  .|.:...:|::..:|..|            .:...||.....:.|..|...| |.....
  Fly   505 ------HAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADTDYTVTCSAKGKPA-PSVKWL 562

Human   262 REMGETLPEKPGEYRLSQGFSDGSPGL--------------PAG--LEPGRRGL----------- 299
            ::..|.|||: ..|.:......|..|:              |.|  |.||.|||
  Fly   563 KDAVEILPEE-NLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNS 626

Human   300 ---------------------------------CKFSWEPGREQQWEDGWGSNRLVSS 324
                                             ||....|..|.||:.|...:.|..|
  Fly   627 ANSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCGR2B	XP_024309811.1	Ig1_FcgammaR_like	50..128	CDD:143229	18/90 (20%)
FCGR2B	XP_024309811.1	Ig2_FcgammaR_like	132..214	CDD:319307	19/101 (19%)
ed	NP_001260013.1	Ig	50..147	CDD:299845
		I-set	146..249	CDD:254352
		Ig	168..249	CDD:299845
		IGc2	268..323	CDD:197706
		Ig_3	341..406	CDD:290638	17/76 (22%)
		Ig_2	437..514	CDD:290606	17/97 (18%)
		I-set	526..633	CDD:254352	21/108 (19%)
		Ig	546..632	CDD:143165	19/87 (22%)
		IG_like	654..736	CDD:214653	9/31 (29%)
		Ig	656..734	CDD:143165	9/29 (31%)
		FN3	741..848	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910