DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCGR2B and Fcgr2b

DIOPT Version :9

Sequence 1:	XP_024309811.1	Gene:	FCGR2B / 2213	HGNCID:	3618	Length:	324	Species:	Homo sapiens
Sequence 2:	XP_006250295.1	Gene:	Fcgr2b / 289211	RGDID:	631331	Length:	342	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	173/328 - (52%)
Similarity:	218/328 - (66%)	Gaps:	10/328 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQED 65
            ||.|.|||:....:........:...|||||||||.|  ||.:.|..||||:||||.||.||:||
  Rat     1 MGTLLFLPLPMDSNRTVVHVLSRTLYHMLLWTAVLNL--VAESHAGLPKAVVKLEPPWIQVLKED 63

Human    66 SVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLS 130
            :|||.|.|||:.::.|.||||||:.|....|.:|.|||..||||||.|:..:|.:|:|:||.|:|
  Rat    64 TVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVIS 128

Human   131 EWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYH 195
            :||:|||..|.|:|||||.|||||||:|.|.||..|||||..::.....|||||:|||||||:|:
  Rat   129 DWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYY 193

Human   196 CTGNIGYTLYSSKPVTITVQAPSSS---PMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPG 257
            |...:|.|::.|||||||||.|.||   |:..|||.|.||||||||..:|:|:|.:||::.||||
  Rat   194 CKAYLGRTMHVSKPVTITVQEPKSSSSLPVLTIVAAVAGIAVAAIVIILVSLVYLKKKQVPALPG 258

Human   258 YPECREMGETLPEKPGEYRLSQGFS-DGSPGLPAGLEPGRRGLCKFSWEPGREQQWEDGWGSNRL 321
            .|:.|||||.|||:.||||...|.| ..|||.|:||:|.|..    |:.|...::.|.....|.:
  Rat   259 NPDHREMGEALPEELGEYRKPSGGSVPVSPGPPSGLDPTRSS----SYTPSGLEEAEKNEVENTI 319

Human   322 VSS 324
            ..|
  Rat   320 TYS 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCGR2B	XP_024309811.1	Ig1_FcgammaR_like	50..128	CDD:143229	44/77 (57%)
FCGR2B	XP_024309811.1	Ig2_FcgammaR_like	132..214	CDD:319307	50/81 (62%)
Fcgr2b	XP_006250295.1	Ig	48..126	CDD:299845	44/77 (57%)
		IG_like	54..112	CDD:214653	33/57 (58%)
		Ig2_FcgammaR_like	130..212	CDD:143230	50/81 (62%)
		IG_like	136..212	CDD:214653	45/75 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83678855
Domainoid	1	1.000	112	1.000	Domainoid score	I40068
eggNOG	1	0.900	-	-		E1_2ESZP
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2974
Inparanoid	1	1.050	297	1.000	Inparanoid score	I14652
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG34347
OrthoDB	1	1.010	-	-		D1246375at2759
OrthoFinder	1	1.000	-	-		FOG0001730
OrthoInspector	1	1.000	-	-		mtm10029
orthoMCL	1	0.900	-	-		OOG6_120517
Panther	1	1.100	-	-	O	PTHR11481
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270