Protein Alignment ADGRG5 and Adgrg5

DIOPT Version :10

• Sequence 1: XP_011521251.2
• Gene: ADGRG5 / 221188
• HGNCID: 19010
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001139444.1
• Gene: Adgrg5 / 382045
• MGIID: 2685955
• Length: 524
• Species: Mus musculus
• Alignment Length: 530
• Identity: 373/530 - (70%)
• Similarity: 410/530 - (77%)
• Gaps: 10/530 - (1%)

Human    65 MDHCGALFLCLCLLTLQNATTETWEELLSYMENMQ--VSRGRSSVFSSRQLHQLEQMLLNTSFPG 127
            ||..||||..||||..|....||..:||..|:.::  |.||.||  .:|.:|.|||.|||.||.|
Mouse     1 MDPHGALFFYLCLLAAQVVLVETLSDLLVLMKRLEQPVGRGLSS--RARHIHSLEQKLLNASFGG 63

Human   128 YNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQAGGQHARGQHAMQFPAELTRDACKT-RPR 191
            :||||||.:||||.|||||||.||||:|.||..|.|     .|..||||||||||:.||.| ||.
Mouse    64 HNLTLQTNSIQSLVFKLSCDFPGLSLSSTTLTNVSQ-----VRAPHAMQFPAELTKGACVTSRPA 123

Human   192 ELRLICIYFSNTHFFKDENNSSLLNNYVLGAQLSHGHVNNLRDPVNISFWHNQSLEGYTLTCVFW 256
            |||||||||...|.|:|:.||||||||||||||.|..||||:.|||||||||:||||||::||||
Mouse   124 ELRLICIYFFTAHLFQDDRNSSLLNNYVLGAQLDHRPVNNLQKPVNISFWHNRSLEGYTVSCVFW 188

Human   257 KEGARKQPWGGWSPEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCS 321
            ||||.|..||.||||||.|||||.:||||.||||||||||||||...|||||..||.|||.||||
Mouse   189 KEGASKSSWGAWSPEGCYTEQPSATQVLCHCNHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCS 253

Human   322 ISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALH 386
            |||||||:|:||:...||||||.|||||||:.||||||:.||||....:..:|...|..|||.||
Mouse   254 ISIVASLLTILLYAQSRKQSDSTTRIHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLH 318

Human   387 YALLSCLTWMAIEGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIP 451
            |||||.|||||||||||||.||||||.|||||:.||.:||||.|||||||.|.:||||||||...
Mouse   319 YALLSSLTWMAIEGFNLYLFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGPCVTS 383

Human   452 VFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSVRA 516
            :..|.||||||||:|:||:|||:|||:|||||||.||||||||||||||.|.|||.|..|.|..|
Mouse   384 LSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVLAWALWILCRLRAREKALSPWA 448

Human   517 CHDTVTVLGLTVLLGTTWALAFFSFGVFLLPQLFLFTILNSLYGFFLFLWFCSQRCRSEAEAKAQ 581
            ..||..||||||||||||.|||||||||||||||||||.|||||||||||||||:..|:|||||:
Mouse   449 YRDTAMVLGLTVLLGTTWTLAFFSFGVFLLPQLFLFTIFNSLYGFFLFLWFCSQKRYSDAEAKAE 513

Human   582 IEAFSSSQTT 591
            :||.||||.|
Mouse   514 MEAVSSSQMT 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRG5	XP_011521251.2	GPS	252..296	CDD:460350	34/43 (79%)
		7tmB2_GPR114	309..582	CDD:320559	201/272 (74%)
		TM helix 1	311..336	CDD:320559	19/24 (79%)
		TM helix 2	345..367	CDD:320559	17/21 (81%)
		TM helix 3	379..406	CDD:320559	22/26 (85%)
		TM helix 4	419..439	CDD:320559	13/19 (68%)
		TM helix 5	473..502	CDD:320559	25/28 (89%)
		TM helix 6	515..542	CDD:320559	20/26 (77%)
		TM helix 7	546..571	CDD:320559	23/24 (96%)
Adgrg5	NP_001139444.1	GPS	183..228	CDD:460350	34/44 (77%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	185..235		40/49 (82%)
		Stachel. /evidence=ECO:0000250|UniProtKB:Q8IZF4	224..232		7/7 (100%)
		7tm_GPCRs	242..514	CDD:475119	201/271 (74%)
		TM helix 1	244..268	CDD:410628	18/23 (78%)
		TM helix 2	277..298	CDD:410628	16/20 (80%)
		TM helix 3	311..333	CDD:410628	17/21 (81%)
		TM helix 4	353..369	CDD:410628	12/15 (80%)
		TM helix 5	405..428	CDD:410628	19/22 (86%)
		TM helix 6	452..474	CDD:410628	18/21 (86%)
		TM helix 7	478..503	CDD:410628	23/24 (96%)