Protein Alignment SLC39A12 and Zip99C

DIOPT Version :10

• Sequence 1: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_733319.1
• Gene: Zip99C / 43533
• FlyBaseID: FBgn0039714
• Length: 355
• Species: Drosophila melanogaster
• Alignment Length: 342
• Identity: 90/342 - (26%)
• Similarity: 149/342 - (43%)
• Gaps: 70/342 - (20%)

Human   381 SMLGTALV----LF---------HSCEENYR-----LILQLFVGLAVGTLSGDALLHLIPQVLGL 427
            |:||:.::    :|         ...:|.|:     .:|::.:..|||.|.||..|||:|:....
  Fly    39 SLLGSVVIGLSGIFPLIIIPTEEKMAKEGYKDPADSKLLRVLLSFAVGGLLGDVFLHLLPEAWEG 103

Human   428 HKQEAPEFGHFHES-KGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQ--------GLSLVNGH 483
            ..|:...    |.| :..:|.|.|::    .|.::||.|....|.:::.        ...|:..|
  Fly   104 DNQDPSS----HPSLRSGLWVLSGIL----IFTIVEKIFSGYASADEENPQPKCVEIANCLLRRH 160

Human   484 VGHSHHLALNSELSDQAGRGKSASTIQ-------LKSPEDSQAAEMPIGSMTASNRKCKAISLLA 541
            .|.    ....|.|:..|   .|..|:       |:..|..           :..||.:...:..
  Fly   161 GGQ----LPEGETSESCG---GACDIEDVGKVCFLREQEQK-----------SKERKEQPKKVAG 207

Human   542 IMILVGDSLHNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMN 606
            .:.|:.:|:.||..|||:..:|..|...|:..|.|||.||||||:||||:||.||.|...|....
  Fly   208 YLNLLANSIDNFTHGLAVAGSFLVSFRHGILATFAILLHEIPHEVGDFAILLRSGFSRWDAARAQ 272

Human   607 FISSLTAFMGLYIGLS----VSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLL 667
            .:::....:|..:.:.    .||......||...|||.||:::||.:||::...:.::..:..||
  Fly   273 LLTAGAGLLGALVAIGGSGVTSAMEARTSWIMPFTAGGFLHIALVTVLPDLLKEEERKESIKQLL 337

Human   668 QNFGLILGWLSLLLLAI 684
               .|:.|   :.|:|:
  Fly   338 ---ALVFG---IALMAV 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A12	NP_001138667.1	ZIP4_domain	63..222	CDD:465698
		Zip	369..671	CDD:396884	86/327 (26%)
		XEXPHE-motif	580..585		4/4 (100%)
Zip99C	NP_733319.1	Zip	34..350	CDD:396884	90/342 (26%)