Protein Alignment SLC39A12 and Zip71B

DIOPT Version :10

• Sequence 1: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_001097608.1
• Gene: Zip71B / 39626
• FlyBaseID: FBgn0036461
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 158/600 - (26%)
• Similarity: 265/600 - (44%)
• Gaps: 160/600 - (26%)

Human   212 IITLSLQGVCLGQ---GNLPSPDYFTEY---IFSSLNRTNTLRLSELDQLLNTL----------- 259
            ::.|:|  .|||.   ..:|:...:.:|   ||.......|:....|:.|:.:|
  Fly     6 VLVLNL--FCLGSLFFKTVPASTEYNKYVAQIFQKYGNGGTINFEGLEHLMFSLNLGQIQFDPSH 68

Human   260 ---WTRSTCIKNEKIH------QFQRKQNNI---------ITHDQDYSNFSSSME---------- 296
               ..|.....||..|      .|:..:.|.         |:...::||..|..|
  Fly    69 TIDQHRPQGYSNEMPHATNVTYYFEPTRVNATDEEALELQISPRGNHSNSQSEAEVPEFLEIHDP 133

Human   297 -----KESEDGPVSWDQTCFSARQLVEIF-----LQKGLS---LISKED---------------- 332
                 :||.: ||:   .|.|.:.|:.:.     |.|.::   |:.|.|
  Fly   134 KHRHPRESSE-PVA---ACLSPKSLLSLIVNHNDLHKNIAYRKLLIKNDVSSTDGVHNSEEEYNE 194

Human   333 -----------FKQMSPGIIQQLLSCSCHLP-------KDQQAKLPPTTLEKYGYSTVAVTLLTL 379
                       |.::.|.::.|:.:..|..|       .|:..|:      .|.:...::|:|.|
  Fly   195 FINSVRITPRAFMKLCPALLAQIDNGVCKQPAVRSVNLNDKNQKI------WYAWIYASITMLIL 253

Human   380 GS--MLGTALV-LFHSCEENYRLILQLFVGLAVGTLSGDALLHLIPQVL---GLHKQEAP----- 433
            .:  :||..|| |..|..  |:.||:..|.:|||||:||||:||:|..|   ..|::|..
  Fly   254 SACGLLGILLVPLMKSAA--YQEILKFLVSIAVGTLAGDALMHLLPHALFKEEKHEEEVTGINPL 316

Human   434 EFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLVNGHVGHSHHLALNSELSD 498
            |..|.|.::..:......:..:. .:::|....||  ...|.|....:|| ||||
  Fly   317 ESDHKHSNEAALLCGCTFLAALF-MYMLENLIPLL--KGGKPGHGHSHGH-GHSH---------- 367

Human   499 QAGRGKSASTIQLKSPEDSQAAEMP-------------IGSMTASNRKCKAISLLAIMILVGDSL 550
                |:|..  .::.|....|.::|             :...|..    :.::.:|.|:::||.|
  Fly   368 ----GRSHG--HMEKPAAKDAIDLPPPRELNVMLQEAKLDEKTPD----RPLTPVAFMVIIGDGL 422

Human   551 HNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFM 615
            ||..|||||||||:|...:|..|..|:||||:|||:||||:||.:|:||:.|:.||.:||:.:|:
  Fly   423 HNLTDGLAIGAAFASDPVTGFATAFAVLCHELPHELGDFALLLQTGVSMRRAVYMNIVSSVLSFV 487

Human   616 GLYIGLSVS--ADPCVQDWIFTVTAGMFLYLSLVEMLPEMT---HVQTQRPWMMFLLQNFGLILG 675
            |:.:||.::  .|...| ||:..|||.|||::..:::|.|:   :.:..:.....::|.||::||
  Fly   488 GMSVGLFIAGIGDGMTQ-WIYAATAGSFLYIAFADLVPTMSVAHNPEKAKDPKGIIIQIFGILLG 551

Human   676 WLSLLLLAIYEQNIK 690
            .|.:|.:|:.|.:::
  Fly   552 GLIMLAIALNEHDLE 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A12	NP_001138667.1	ZIP4_domain	63..222	CDD:465698	2/9 (22%)
		Zip	369..671	CDD:396884	106/330 (32%)
		XEXPHE-motif	580..585		3/4 (75%)
Zip71B	NP_001097608.1	Zip	242..559	CDD:396884	112/343 (33%)