Protein Alignment SLC39A12 and foi

DIOPT Version :10

• Sequence 1: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_523974.3
• Gene: foi / 38976
• FlyBaseID: FBgn0024236
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 148/657 - (22%)
• Similarity: 259/657 - (39%)
• Gaps: 230/657 - (35%)

Human   201 NESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRS-- 263
            :||.:||:.                     .|:.|.:.:.....|:   |..|.||..|...|
  Fly    96 SESRVPQIT---------------------QYYLEKLMAQDELMNS---SGFDGLLQQLSLHSLA 136

Human   264 ------TCIKNEK-IHQFQRKQNNIITHDQDYSNFSSSMEKESEDGPVSWDQTCFSARQLVEIFL 321
                  ||:...: :|..|       .||..:::     ..|.||..:..: .|        ..:
  Fly   137 SGASEGTCVPGSRLVHHVQ-------PHDHHHAH-----HHEEEDHSLQLN-NC--------TLI 180

Human   322 QKGLS-----------------------LISKEDFKQMSPGIIQQLLSCS--CHLPK-----DQQ 356
            |.|.:                       .:|.:|...:.|.::.:|.:.|  |..|.     |..
  Fly   181 QNGTTSNVICPSLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTT 245

Human   357 AKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDA 416
            .:|.....:|     :.|:.::|....:..::|.|::.|.. ...|:.|:|..|.|||||::|||
  Fly   246 EELLEAEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMG-SRYYKYIIQYLVALAVGTMTGDA 309

Human   417 LLHLIPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILL------------- 468
            ||||:|..|.           ..:.:|.|.|.:|.:|||..|:::|....::
  Fly   310 LLHLLPHSLA-----------GQDERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETK 363

Human   469 --------------------------------------VSPNDKQG------------------- 476
                                                  ::.|:||.
  Fly   364 KPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPS 428

Human   477 -LSLVNG---HVG------------------------HSHHLALNSELSDQAGR----------G 503
             ..|.||   |.|                        |:|:...||...:..|:          |
  Fly   429 VAELRNGVGDHDGSNDMAAAAESLISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTIVTDLDG 493

Human   504 KSASTIQLKSPEDSQAAEMPI----------------GSMTASNRKCKAISLLAIMILVGDSLHN 552
            .:...:.....:||:...:.:                |.:   :...:.:|.:|.||::||.|||
  Fly   494 NAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSHRHGHV---HSPPETLSAVAWMIIMGDGLHN 555

Human   553 FADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFMGL 617
            |.||:||||||:.:...|.:|::|:.|||:|||:||||:|:.:|:|:|:|:..|.::.:.:|:|:
  Fly   556 FTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGM 620

Human   618 YIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLLQNFGLILGWLSLLLL 682
            ..|::......|..|:|.|.||:|:|::||:|:||::  .:.:....||||..|::.|...:||:
  Fly   621 IFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEIS--ASHKSLGQFLLQILGMLSGVGIMLLI 683

Human   683 AIYEQNI 689
            |:||.::
  Fly   684 ALYEGDL 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A12	NP_001138667.1	ZIP4_domain	63..222	CDD:465698	4/20 (20%)
		Zip	369..671	CDD:396884	106/425 (25%)
		XEXPHE-motif	580..585		3/4 (75%)
foi	NP_523974.3	Zip	258..684	CDD:396884	110/442 (25%)