Protein Alignment SLC39A12 and Zip48C

DIOPT Version :10

• Sequence 1: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Sequence 2: NP_610712.1
• Gene: Zip48C / 36273
• FlyBaseID: FBgn0033665
• Length: 341
• Species: Drosophila melanogaster
• Alignment Length: 381
• Identity: 84/381 - (22%)
• Similarity: 140/381 - (36%)
• Gaps: 110/381 - (28%)

Human   367 YGYSTVAV--TLLTLG-SMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDALLHLIPQVLGLH 428
            ||..|.|:  ||||.| :..|.|||:|  ...|.|..|...:|.|.|.:...:...|:...:
  Fly     5 YGPVTQALLGTLLTWGLTAAGAALVIF--VRGNQRRSLDAALGFAAGVMIAASFWSLLKPAI--- 64

Human   429 KQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFI--------------------------- 466
              |..|..|.:    .::..:.:.||    ||:...|:
  Fly    65 --EMAESSHLY----GVYAFLPVAGG----FLLGSIFVYGCDKLMSYLGLNSTNMMIQMTQSKAK 119

Human   467 --LLVSPNDKQGLS---------------LVNGHVGHSHHLALNSELSDQAGRGKSASTIQLK-- 512
              :.:..:.:.|::               |...|.|.|..            |.|.||..:::
  Fly   120 ADIAIEDSKRNGVAPDRLASKSLDSFSDCLSVQHSGESRR------------RKKGASINEMEQC 172

Human   513 ---SPEDSQAAEMPIGSMTASNRKCKAISLLAIMILVGDSLHNFADGLAIGAAF-------SSSS 567
               :||:.|.||..:.       :.|.|.||.:.|.|    ||..:|||:|.:|       ||:.
  Fly   173 TYTTPEEQQRAEDALS-------QWKRIMLLVVAITV----HNIPEGLAVGVSFGAIGSTNSSTF 226

Human   568 ESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLT-AFMGLYIGLSVSADPCVQD 631
            ||.....|.|.....|..:.....|.::|.|:|.|:....:|.:. ...|:...::|:....:..
  Fly   227 ESARNLAIGIGIQNFPEGLAVSLPLHAAGFSVKRALWYGQLSGMVEPIFGVLGAVAVTFANLILP 291

Human   632 WIFTVTAGMFLYLSLVEMLPEMTHVQ---TQRPWMMFLLQNFGLILGWLSLLLLAI 684
            :..:..||..:|:...::||| .|..   |...|        |.:.|:|.::.|.:
  Fly   292 YALSFAAGAMIYIVSDDILPE-AHASGNGTIATW--------GTVSGFLIMMCLEV 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A12	NP_001138667.1	ZIP4_domain	63..222	CDD:465698
		Zip	369..671	CDD:396884	78/364 (21%)
		XEXPHE-motif	580..585		1/4 (25%)
Zip48C	NP_610712.1	ZupT	23..339	CDD:440197	75/363 (21%)