DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JMJD1C and Jmjd1c

DIOPT Version :9

Sequence 1:	NP_116165.1	Gene:	JMJD1C / 221037	HGNCID:	12313	Length:	2540	Species:	Homo sapiens
Sequence 2:	XP_006256421.2	Gene:	Jmjd1c / 171120	RGDID:	708458	Length:	2526	Species:	Rattus norvegicus

Alignment Length:	2541	Identity:	2150/2541 - (84%)
Similarity:	2301/2541 - (90%)	Gaps:	18/2541 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVEFDDLE 65
            ||||||.|||||||||||.|::||.||.:||.| |.|||||||||||||..:|||||||||||||
  Rat     1 MAVETRPELVGKRFLCVAAGEDARPERGQSGCG-RGWRAGVIRAVSHRDRGHPDLAVYVEFDDLE 64

Human    66 WDKREWVKVYEDFSTFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALTFKPLVERNIPSSVTAVEF 130
            |||||||||||||||||||||||||||.||||||||||:||||||||||||||.:||||||||||
  Rat    65 WDKREWVKVYEDFSTFLVEYHLIWAKRKDPSQTQGSKSRQIQWPALTFKPLVENSIPSSVTAVEF 129

Human   131 LVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLHEEVKVWVKEQKVQEIFMQGPYSLNGYRVR 195
            |:|||:|||||:||||.||||||||.|.||||||||.||||||||||||||||||||||||||||
  Rat   130 LIDKQVDFLTEESAFQLYQDDIDSLKPELRDNPQLHAEVKVWVKEQKVQEIFMQGPYSLNGYRVR 194

Human   196 VYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 VYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITS 259

Human   261 RRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEE 325
            ||||||:||::.||.||||||||||||||||||||||||||||||||||||:||||||||.||||
  Rat   260 RRRSRASQNISTVHGHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPSKRKGSDSSAPDEE 324

Human   326 KMKEEKYDYISRGENPKGKNKHLMNKRRKPEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIID 390
            :||.:||||.||||||||||||::.||||||||||:|.||||||||.||.|||||||||:|||.:
  Rat   325 RMKGDKYDYGSRGENPKGKNKHMVTKRRKPEEDEKRLTMKRLRTDNASDASESSDSENSSKRITE 389

Human   391 NSSEQKPENELKNKNTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDTQ 455
            |||||.||.|||||.|||||||:|:|...||||||.|.:::|.|||:||||.|||.||.||:|:.
  Rat   390 NSSEQTPEYELKNKITSKINGEDGQPQAAEKAGEEILIDTRPHWDQMQEDKNHEEGEKLKSMDSH 454

Human   456 LQEDMIIHSSEQSTVSDHNSNDLLPQECNMDKTHTMELLPKEKFVSRPPTPKCVIDITNDTNLEK 520
            ||:.:.:.:|||:|.:|.||||.:.|||||:...|:||..|::.|||.|||||.:||.|||:.|:
  Rat   455 LQDKITLRASEQATDADPNSNDSVLQECNMENQRTVELPSKDRVVSRTPTPKCAMDIKNDTHSER 519

Human   521 VAQENSSTFGLQTLQKMDPNVSDSKHSIANAKFLETAKKDSDQSWVSDVVKVDLTQSSVTNASSG 585
            .|||.|:|||||..:.||.||||||||  |||:||.||||.|||||||||||||||||.||..||
  Rat   520 AAQEKSNTFGLQIPENMDSNVSDSKHS--NAKYLEAAKKDCDQSWVSDVVKVDLTQSSTTNTPSG 582

Human   586 NDHLNMEKEK--YVSYISPLSAVSVMEDKLHKRSPPPETIKSKLNTSVDTHKIKSSPSPEVVKPK 648
            ||:..||||:  ||||:|.||.|||.||:|||||||||||:|||.|||||.|.|||.||||.|||
  Rat   583 NDNREMEKERNHYVSYMSSLSTVSVTEDQLHKRSPPPETIRSKLTTSVDTQKTKSSSSPEVFKPK 647

Human   649 ITHSPDSVKSKATYVNSQATGERRLANKIEHELSRCSFHPIPTRSSTLETTKSPLIIDKNEHFTV 713
            :|||||||||:|.|.||||.||||.|:|.||||||.|||..|||.|.||||||||||||||||||
  Rat   648 VTHSPDSVKSRAAYGNSQAAGERRQASKAEHELSRGSFHAAPTRGSALETTKSPLIIDKNEHFTV 712

Human   714 YRDPALIGSETGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTIN 778
            ||||||||||.||||||||||||||||||||||||||||:|||||||.|||||||||||||||||
  Rat   713 YRDPALIGSEAGANHISPFLSQHPFPLHSSSHRTCLNPGSHHPALTPGPHLLAGSSSQTPLPTIN 777

Human   779 THPLTSGPHHAVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQSPH 843
            ||||||||||.||||||||||||||||||||||||||||||..||||||||| ||||||||||||
  Rat   778 THPLTSGPHHPVHHPHLLPTVLPGVPTASLLGGHPRLESAHTGSLSHLALAH-QQQQLLQHQSPH 841

Human   844 LLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQP 908
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   842 LLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQP 906

Human   909 TPVTSADGIGLLSHIPVRPSSAEPHRPLKITAHSSPPLTKTLVDHHKEELERKAFMEPLRSVAST 973
            ||||||||||||||||||||||||.||.|:|.||||||||||.||||||||||||||||||.|||
  Rat   907 TPVTSADGIGLLSHIPVRPSSAEPPRPHKMTVHSSPPLTKTLADHHKEELERKAFMEPLRSNAST 971

Human   974 SAKNDLDLNRSQTGKDCHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTK 1038
            |.|.||||||||.|||||||||||.|      |.|.|||||||||||||||||||||||||||||
  Rat   972 SVKGDLDLNRSQAGKDCHLHRHFVGP------RLPPETGERLNKYKEEHRRILQESIDVAPFTTK 1030

Human  1039 IKGLEGERENYSRVASSSSSPKSHIIKQDMDVERSVSDLYKMKHSVPQSLPQSNYFTTLSNSVVN 1103
            |||.|.||||||||..||||||||.||.|.|::||||:||||||||.||||||||||||||||:|
  Rat  1031 IKGHEVERENYSRVVPSSSSPKSHAIKPDKDMDRSVSELYKMKHSVSQSLPQSNYFTTLSNSVLN 1095

Human  1104 EPPRSYPSKEVSNIYGDKQSNALAAAAANPQTLTSFITSLSKPPPLIKHQPESEGLVGKIPEHLP 1168
            ||||||||||||:|:.:||::.| :|||||||| |||:||||||||||||||||.||||:|:|||
  Rat  1096 EPPRSYPSKEVSSIHTEKQNSNL-SAAANPQTL-SFISSLSKPPPLIKHQPESESLVGKVPDHLP 1158

Human  1169 HQIASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKEGSYSSLSPPTLT 1233
            ||.|||||||||:||||||||||.|||.|||||||||||||||||||||||||.|||||||||||
  Rat  1159 HQSASHSVTTFRSDCRSPTHLTVCSTNALRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLT 1223

Human  1234 PVMPVNAGGKVQESQKPPTLIPEPKDSQANFKSSSEQSLTEMWRPNNNLSKEKTEWHVEKSSGKL 1298
            ||||||||||.||||||||||||||||||:.| ||:|||.|:|| :|||||||.||.|||:|||.
  Rat  1224 PVMPVNAGGKAQESQKPPTLIPEPKDSQADLK-SSDQSLVEVWR-SNNLSKEKAEWPVEKNSGKS 1286

Human  1299 QAAMASVIVRPSSSTKTDSMPAMQLASKDRVSERSSAGAHKTDCLKLAEAGETGRIILPNVNSDS 1363
            |||:|||||||.||||.||:|:..||:||||.||:|:||:|||.|| .||||||||:|||||.:|
  Rat  1287 QAAVASVIVRPPSSTKVDSVPSGPLAAKDRVCERASSGANKTDYLK-PEAGETGRILLPNVNLES 1350

Human  1364 VHTKSEKNFQAVSQGSVPSSVMSAVNTMCNTKTDVITSAADTTSVSSWGGSEVISSLSNTILAST 1428
            .|.||||||:|.||||||.|||||||.:..|:|||:|||..||||||..|||...||||.|.|||
  Rat  1351 AHVKSEKNFEAASQGSVPVSVMSAVNVVSATQTDVLTSAGPTTSVSSLAGSEATYSLSNIISAST 1415

Human  1429 SSECVSSKSVSQPVAQKQECKVSTTAPVTLASSKTGSVVQPSSGFSGTTDFIHLKKHKAALAAAQ 1493
            ..||.|||||||.|||.:.|||||..|||||.|||.:.|||.|||||||||||||||||||||||
  Rat  1416 PLECPSSKSVSQSVAQAKGCKVSTPVPVTLACSKTANAVQPGSGFSGTTDFIHLKKHKAALAAAQ 1480

Human  1494 YKSSNASETEPNAIKNQTLSASLPLDSTVICSTINKANSVGNGQASQTSQPNYHTKLKKAWLTRH 1558
            ||:||.||.|.|.::|||.:||||||||:.|:..|||.|||||.|:|.|||||||||||||||||
  Rat  1481 YKNSNVSEAELNTVRNQTAAASLPLDSTMTCAASNKAVSVGNGPAAQPSQPNYHTKLKKAWLTRH 1545

Human  1559 SEEDKNTNKMENSGNSVSEIIKPCSVNLIASTSSDIQNSVDSKIIVDKYVKDDKVNRRKAKRTYE 1623
            ||||||||||||||..|||:|||||||||||||||||||||.::.||||.:|:|.:|||||||||
  Rat  1546 SEEDKNTNKMENSGTCVSEMIKPCSVNLIASTSSDIQNSVDGRVTVDKYGRDEKASRRKAKRTYE 1610

Human  1624 SGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKERSKLKLQS 1688
            |||||.|||.||||:||||||||||||||||||||||||||||||||||||||||||:||||||:
  Rat  1611 SGSESADSDGSESKAEQRTKRQPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKEKSKLKLQN 1675

Human  1689 NSNTGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPAHSPVFCR 1753
            :|:.|:||||||||||||||||||||||||||||||||||||||||||||||||||..|||||||
  Rat  1676 SSSAGVPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEESTHSPVFCR 1740

Human  1754 FYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENFEDDELDIETSKYILDIIGDKFCQLVT 1818
            ||||||||||||||||||||||||||||||||||||||:|||::|:|||||||||||||||||||
  Rat  1741 FYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDDIDVETSKYILDIIGDKFCQLVT 1805

Human  1819 SEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDK 1883
            |||||||||||||||||||||||||||||||||||||:||||:|||||.||||||||||||||||
  Rat  1806 SEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNVHWVCRKCGFVACLDCYKAKERKSSRDK 1870

Human  1884 ELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNLQVGNFPT 1948
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||.|:||||.||.||
  Rat  1871 ELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHVLREKYGIKSHCHCANRQNLQGGNVPT 1935

Human  1949 MNGVSQVLQNVLNHSNKISLCMPESQQQNTPPKSEKNGGSSPESDVGTDNKLTPPESQSPLHWLA 2013
            ||||||||||.|:||||.|.|.||||||:||.:::.||.|||.| ..||::||||||||||||||
  Rat  1936 MNGVSQVLQNALHHSNKTSACPPESQQQSTPQRAQANGSSSPGS-ASTDSRLTPPESQSPLHWLA 1999

Human  2014 DLAEQKAREEKKENKELTLENQIKEEREQDNSESPNGRTSPLVSQNNEQGSTLRDLLTTTAGKLR 2078
            ||||||:||||:||||.|||.:|||:.|||..:||||.|||..|||:||||||||||||||||||
  Rat  2000 DLAEQKSREEKQENKEFTLEKEIKEDEEQDTPDSPNGSTSPPASQNSEQGSTLRDLLTTTAGKLR 2064

Human  2079 VGSTDAGIAFAPVYSMGAPSSKSGRTMPNILDDIIASVVENKIPPSKTSKINVKPELKEEPEESI 2143
            ||||||||||||||||||.|.|.||||||||||||||||||||||:||||||||.|..|||:||.
  Rat  2065 VGSTDAGIAFAPVYSMGASSGKGGRTMPNILDDIIASVVENKIPPNKTSKINVKSEPNEEPKESR 2129

Human  2144 ISAVDENNKLYSDIPHSWICEKHILWLKDYKNSSNWKLFKECWKQGQPAVVSGVHKKMNISLWKA 2208
            .||.:|:||.|.||||:|||::|:|||||||||:|||||||||||||||||||||||||:|||||
  Rat  2130 QSATNESNKFYRDIPHTWICDQHVLWLKDYKNSNNWKLFKECWKQGQPAVVSGVHKKMNVSLWKA 2194

Human  2209 ESISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKNKSGETVVLKLKDWPSGEDFKTM 2273
            |||||||||||||||||||||:||||||||||||||||||||||.||||||||||.|||||||||
  Rat  2195 ESISLDFGDHQADLLNCKDSIVSNANVKEFWDGFEEVSKRQKNKGGETVVLKLKDCPSGEDFKTM 2259

Human  2274 MPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVVAAKDHDIGTTNLHIE 2338
            |||||||.|:|||||||||||||||||||||||||||||||||||||||.|||||||||||||||
  Rat  2260 MPARYEDFLRSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHIE 2324

Human  2339 VSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIR 2403
            .|||||:|||||||||||:|||||||||||||:||||||||||||||||||||||||||||||||
  Rat  2325 ASDVVNVLVYVGIAKGNGVLSKAGILKKFEEEELDDILRKRLKDSSEIPGALWHIYAGKDVDKIR 2389

Human  2404 EFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVRTCTLIQFLGDAIVLPAGALHQV 2468
            |||||:||||||||||||||:|||.||||::||||||||||||.|||:||||||||||||.||||
  Rat  2390 EFLQKVSKEQGLEVLPEHDPVRDQGWYVNRRLRQRLLEEYGVRACTLVQFLGDAIVLPAGTLHQV 2454

Human  2469 QNFHSCIQVTEDFVSPEHLVESFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKIHEDE 2533
            ||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||:||||
  Rat  2455 QNFHSCIQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKMHEDE 2519

Human  2534 VEDMEE 2539
            |||||:
  Rat  2520 VEDMED 2525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD1C	NP_116165.1	RX-CC_like	127..>175	CDD:271353	40/47 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..478		151/199 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..656		19/24 (79%)
		Sox_C_TAD	<728..>795	CDD:288887	63/66 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1242..1263		19/20 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1614..1692		70/77 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2064		65/92 (71%)
		LXXLL motif	2066..2070		3/3 (100%)
		JmjC	2278..2350	CDD:214721	66/71 (93%)
		cupin_like	2382..2481	CDD:304367	90/98 (92%)
Jmjd1c	XP_006256421.2	RX-CC_like	126..>174	CDD:421994	40/47 (85%)
		JmjC	2264..2336	CDD:214721	66/71 (93%)
		cupin_RmlC-like	2368..2467	CDD:424065	90/98 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83684671
Domainoid	1	1.000	3954	1.000	Domainoid score	I31
eggNOG	1	0.900	-	-		E1_KOG1356
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3129
Inparanoid	1	1.050	4325	1.000	Inparanoid score	I172
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47566
OrthoDB	1	1.010	-	-		D1185631at2759
OrthoFinder	1	1.000	-	-		FOG0010421
OrthoInspector	1	1.000	-	-		oto131712
orthoMCL	1	0.900	-	-		OOG6_102953
Panther	1	1.100	-	-	LDO	PTHR12549
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270