Protein Alignment SLC16A9 and hrm

DIOPT Version :10

• Sequence 1: XP_016871372.1
• Gene: SLC16A9 / 220963
• HGNCID: 23520
• Length: 551
• Species: Homo sapiens
• Sequence 2: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Alignment Length: 624
• Identity: 156/624 - (25%)
• Similarity: 254/624 - (40%)
• Gaps: 162/624 - (25%)

Human     7 PDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSL 71
            |||||||:::..|.||..|..|:..:.|||:.|:.|||.....|.||:.:|...:.....||.|:
  Fly    50 PDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSI 114

Human    72 CVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRR 136
            ....:..|.||:..|...:.|::||.:|.:|.||:.|||::||:|.||.:..||.|...||...|
  Fly   115 LSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLR 179

Human   137 GLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPK- 200
            |||.||..:||::|..|...|.|.|:|.||..|..||:|.:.||:........|::.....:|:
  Fly   180 GLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRA 244

Human   201 KIAPEDLPDKYSI-YNEKGKNLEENI---NILDK---SYSS---------EEKCRITLA------ 243
            :.|.|::|::..| ...|.:|::|.:   ...||   .|:|         :|:.:...:
  Fly   245 RQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVV 309

Human   244 -----NGDWKQD---------SLLHKNPTVT-----------HTKEPETYKKKVAEQTYFCKQLA 283
                 :||..|.         .|..:|.|.|           ...|..:...|:..:.....:|:
  Fly   310 QSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLS 374

Human   284 KRKWQ----LYKN--YCGETVALFKNKVFSA---------------------------------- 308
            ||...    ||.:  |.|.|:: |:.|.||:
  Fly   375 KRSPSTSSFLYVSTPYHGSTLS-FQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQA 438

Human   309 -------LFIAILLFDIGGFPPSLLMEDVARSSN-VKEEEFI--MP---------------LISI 348
                   .|...||.|     |..|:..::.|:| :....||  :|               |:|:
  Fly   439 QQPQRSKFFDLSLLKD-----PMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSV 498

Human   349 IGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNW- 412
            :.....:|::....|:|..:|...:.:|..|.|.||:|..:|||.:|.::.....:.|..:|.:
  Fly   499 VSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWTYSSVCFWCALFGLASGIYV 563

Human   413 SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGKIFILKSSHFTVLPCHISRYRGPDCN 477
            .|...:....:|.|:|..:|||.:|..||...:|||:                          ||
  Fly   564 GITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPL--------------------------CN 602

Human   478 SSTDLYKRNLHGTSHGWFYDWTQTYDIAFYFSGFCVLLG 516
                            ::::....|:..|:..|..:|.|
  Fly   603 ----------------YWFEAVNDYNPLFHALGLTLLAG 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A9	XP_016871372.1	MFS_MCT9	12..524	CDD:340986	151/619 (24%)
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	67/175 (38%)
		MFS	<451..633	CDD:475125	48/222 (22%)