DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tshr and Lgr4

DIOPT Version :9

Sequence 1:	NP_035778.3	Gene:	Tshr / 22095	MGIID:	98849	Length:	764	Species:	Mus musculus
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	179/762 - (23%)
Similarity:	301/762 - (39%)	Gaps:	191/762 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 SLRGKECASP----PCECHQEDDFRVTCK--ELHRIPSLPP--STQTLKLIETHLKTIPSLAFSS 74
            :||..||..|    .|.|..::   :.|:  :|..||...|  ...||.|...:.:||....||.
  Fly   147 NLRIGECLWPNENFSCPCRGDE---ILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSE 208

Mouse    75 LPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLR 139
            ||::..:.|.. .:::.:..|:|..|:.       |.....|:|.:.|..||           ..
  Fly   209 LPDVDSLVLKF-CSIREIASHAFDRLAD-------NPLRTLYMDDNKLPHLP-----------EH 254

Mouse   140 IFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAF-NGTKLD 203
            .||:..::      .||.:..| ::..:..:.|..| .:...|.|..|...:.:...| ....|:
  Fly   255 FFPEGNQL------SILILARN-HLHHLKRSDFLNL-QKLQELDLRGNRIGNFEAEVFARLPNLE 311

Mouse   204 AVYLNKNKYLTAIDNDAFGGVYSGP-TLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSL 267
            .:|||:| :|..:|.|.|      | |||::.:.|:.       .:..|.||.:|:...:    |
  Fly   312 VLYLNEN-HLKRLDPDRF------PRTLLNLHTLSLA-------YNQIEDIAANTFPFPR----L 358

Mouse   268 SFLHLTRADLSY---PSHCCAFK------NQKKIRGI-LESLMCNESSIRNLRQRKSVNILRGPI 322
            .:|.|....||:   .:.|....      |:.:|.|. ||:..|    ::||    |..:|.|
  Fly   359 RYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFAC----LKNL----SSLLLTG-- 413

Mouse   323 YQEYEEDPGDNSVGYKQNSKFQESPS------NSHYYVFFEEQEDEVVGFGQELKNPQEETLQAF 381
                              ::||...|      .|..|::|..
  Fly   414 ------------------NRFQTLDSRVLKNLTSLDYIYFSW----------------------- 437

Mouse   382 ESHYDYTVCGDNEDM-VCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYK 445
                 :.:|....:: ||.|..|..:....::..:.||..||.::.:|::||:.|||.......:
  Fly   438 -----FHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSR 497

Mouse   446 LTVPRFL-MCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSV 509
            ..|...| :.:||.:||.||:||.|||..|:....||..:...|:....|..|||.:.|:.:.|.
  Fly   498 SNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSST 562

Mouse   510 YTLTVITLERWYAITFAM--RLDRKIRLRHAYTIMAGGWVSCFLLALLPMV-----GISSYAKVS 567
            ..||::|.:|..::|..:  |...|:|:.....::   |...|.||..|::     |...|....
  Fly   563 LLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLL---WGISFGLAAAPLLPNPYFGSHFYGNNG 624

Mouse   568 ICLPMDTDTPLALAY---IVLVLLLNVVAFVVVCSCYVKIYITVRNPQYNPRD----KDTKIAKR 625
            :||.:....|.|..:   .:|.:|:|.::.:.:...|:::...:|:.....|.    ::..:|.|
  Fly   625 VCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATR 689

Mouse   626 MAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI-------LLVLFYPLNSCANPFLYAIFTK 683
            .|:::.||..|..||....|:||        :..:|       |.||..|:||..||.||.:.|.
  Fly   690 FAIIVTTDCACWLPIIVVKLAAL--------SGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTA 746

Mouse   684 AFQRDVFILLSKFGICKRQAQAYQGQRVC--------PNNSTGIQIQ 722
            ||::                   |.:|.|        .||.|..|.|
  Fly   747 AFKQ-------------------QLRRYCHTLPSCSLVNNETRSQTQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tshr	NP_035778.3	leucine-rich repeat	54..77	CDD:275380	8/22 (36%)
		LRR_5	65..221	CDD:290045	35/156 (22%)
		leucine-rich repeat	78..102	CDD:275380	4/23 (17%)
		LRR 1	100..124		5/23 (22%)
		leucine-rich repeat	103..127	CDD:275380	5/23 (22%)
		LRR 2	125..150		4/24 (17%)
		leucine-rich repeat	128..152	CDD:275380	2/23 (9%)
		LRR 3	151..174		4/22 (18%)
		leucine-rich repeat	153..177	CDD:275380	5/23 (22%)
		LRR 4	176..199		4/23 (17%)
		leucine-rich repeat	181..201	CDD:275380	4/20 (20%)
		LRR 5	200..223		9/22 (41%)
		leucine-rich repeat	202..226	CDD:275380	9/23 (39%)
		LRR 6	225..248		5/23 (22%)
		LRR 7	264..288		6/32 (19%)
		7tm_4	423..>556	CDD:304433	41/135 (30%)
		7tm_1	431..678	CDD:278431	73/268 (27%)
		PDZ-binding	762..764
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	58/257 (23%)
		LRR_8	188..248	CDD:290566	16/67 (24%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	4/23 (17%)
		leucine-rich repeat	238..261	CDD:275380	7/33 (21%)
		LRR_8	261..320	CDD:290566	14/67 (21%)
		leucine-rich repeat	262..285	CDD:275380	5/30 (17%)
		LRR_4	284..325	CDD:289563	10/41 (24%)
		leucine-rich repeat	286..309	CDD:275380	4/22 (18%)
		LRR_4	308..348	CDD:289563	15/53 (28%)
		leucine-rich repeat	310..334	CDD:275380	12/30 (40%)
		leucine-rich repeat	335..357	CDD:275380	5/28 (18%)
		LRR_8	356..416	CDD:290566	17/91 (19%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		LRR_4	381..421	CDD:289563	13/67 (19%)
		leucine-rich repeat	382..405	CDD:275380	6/26 (23%)
		leucine-rich repeat	406..427	CDD:275380	7/44 (16%)
		7tm_1	483..741	CDD:278431	73/268 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810