DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FCGR1A and ed

DIOPT Version :9

Sequence 1:NP_001365733.1 Gene:FCGR1A / 2209 HGNCID:3613 Length:375 Species:Homo sapiens
Sequence 2:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster


Alignment Length:268 Identity:66/268 - (24%)
Similarity:108/268 - (40%) Gaps:32/268 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    34 VFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRC--QRGL--SGRS 94
            |.::.|..|.|.|...|...:.:|..||....:|. .:.|...||.|:|:|.|  ..||  :|..
  Fly   265 VERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSL-VHTIHRVSVQDAGKYTCIADNGLGKTGEQ 328

Human    95 DPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSN-LTILK 158
            :.|...::...::::..:|...||:.:.:||:...:.....:.:.:...  ..|.:|.: ||:..
  Fly   329 ELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENS--PDFRYNGDVLTLTS 391

Human   159 TNISHNGTYHC------SGMGKHRYTSAGISVTVKELFPAPVLNASVT--SPLLE-GNLVTLSCE 214
            ....|.|.|.|      ...|..|....|.| ||..|.......|.:|  .|::. ||.|||:|.
  Fly   392 VRADHAGNYICRAVNIMQSQGMERSERVGNS-TVALLVRHRPGQAYITPNKPVVHVGNGVTLTCS 455

Human   215 TKLLLQRPGLQLYFSFYMGSKTLRGRNTSS--------EYQILTARREDSGLYWCEAATEDGNVL 271
            .    ..||..:  ..|...:.:.|..:|:        :|.|..|...:.|.|.|.|..|.|..:
  Fly   456 A----NPPGWPV--PQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGM 514

Human   272 KRSPELEL 279
            ..:..||:
  Fly   515 MATIVLEI 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FCGR1ANP_001365733.1 Ig1_FcgammaR_like 23..101 CDD:409410 21/70 (30%)
Ig strand B 40..44 CDD:409410 1/3 (33%)
Ig strand C 54..58 CDD:409410 0/3 (0%)
Ig strand E 69..73 CDD:409410 0/3 (0%)
Ig strand F 83..88 CDD:409410 2/6 (33%)
Ig strand G 94..97 CDD:409410 0/2 (0%)
Ig2_FcgammaR_like 105..186 CDD:409411 17/87 (20%)
Ig strand B 121..125 CDD:409411 0/3 (0%)
Ig strand C 135..139 CDD:409411 0/3 (0%)
Ig strand E 152..156 CDD:409411 1/4 (25%)
Ig strand F 166..171 CDD:409411 2/10 (20%)
Ig strand G 179..182 CDD:409411 0/2 (0%)
ig 197..275 CDD:395002 23/88 (26%)
Interaction with EPB41L2. /evidence=ECO:0000269|PubMed:18023480 313..333
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..375
edNP_001260013.1 Ig 50..147 CDD:299845
I-set 146..249 CDD:254352
Ig 168..249 CDD:299845
IGc2 268..323 CDD:197706 17/55 (31%)
Ig_3 341..406 CDD:290638 13/66 (20%)
Ig_2 437..514 CDD:290606 22/82 (27%)
I-set 526..633 CDD:254352
Ig 546..632 CDD:143165
IG_like 654..736 CDD:214653
Ig 656..734 CDD:143165
FN3 741..848 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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