DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsg101 and TSG101

DIOPT Version :9

Sequence 1:	NP_068684.1	Gene:	Tsg101 / 22088	MGIID:	106581	Length:	391	Species:	Mus musculus
Sequence 2:	NP_524120.1	Gene:	TSG101 / 39881	FlyBaseID:	FBgn0036666	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	204/414 - (49%)
Similarity:	272/414 - (65%)	Gaps:	36/414 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 AVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGN 66
            ||.|:|:.|.:|||||...|.:..|:|:..::.|...|..:|||||||:||..:.|||||.|:.|
  Fly     3 AVEETQITKYLSKYKYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKNN 67

Mouse    67 IYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIM 131
            .|.||||:||:||:|.|.|:||||||.:|.||...:||.|||:||||||||:...|:||.|||:|
  Fly    68 TYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQVM 132

Mouse   132 IVIFGEEPPVFSRP--TVSASYPPYTATGPPNTSYM--PGMPSGISA---YP-------SGYPPN 182
            ||.||:.|||:|:|  .::|.|        |..|||  ||.|.|.::   ||       |.:||.
  Fly   133 IVTFGDHPPVYSKPKEQIAAPY--------PTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPPY 189

Mouse   183 PSGYPGCPYP--PAGP-----YPA------TTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISA 234
            |:|....|||  ||||     |||      .|:..||.........||..|||:|:.|:||:|||
  Fly   190 PTGSNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGGYPPAAGYNPSNPSSTGTITEEHIKASIISA 254

Mouse   235 VSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEEL 299
            :.||||.|::|:::..|||:..|.||:::|.:|..|::.::.||::|..::.|||.:||.|::||
  Fly   255 IDDKLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILKDKEQEL 319

Mouse   300 SSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHV 364
            ..|||.:|:....|. ||.:..|||||:|:||.||:|.|.||.|:||||.||.|||||:.|||||
  Fly   320 EKALEDLESAEAINP-DEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLETFLKHV 383

Mouse   365 RLLSRKQFQLRALMQKARKTAGLS 388
            |.||||||.|||.|||.|:.|||:
  Fly   384 RQLSRKQFILRATMQKCRQKAGLA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsg101	NP_068684.1	UEV	21..139	CDD:399041	66/117 (56%)
		Interaction with CEP55. /evidence=ECO:0000250	159..163		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..220		8/28 (29%)
		SMC_prok_B	<242..>384	CDD:274008	74/141 (52%)
		Vps23_core	317..376	CDD:401418	40/58 (69%)
		PTAP/PSAP motif	321..324		1/2 (50%)
TSG101	NP_524120.1	UEV	22..140	CDD:283415	66/117 (56%)
		ARS2	<149..227	CDD:282772	29/85 (34%)
		TBPIP	<242..353	CDD:284512	49/111 (44%)
		Vps23_core	336..393	CDD:286532	39/56 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838110
Domainoid	1	1.000	154	1.000	Domainoid score	I4259
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2070
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54978
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto94572
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	LDO	PTHR23306
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5678
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790