DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpc2 and trp

DIOPT Version :9

Sequence 1:	NP_001103367.1	Gene:	Trpc2 / 22064	MGIID:	109527	Length:	890	Species:	Mus musculus
Sequence 2:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster

Alignment Length:	858	Identity:	263/858 - (30%)
Similarity:	401/858 - (46%)	Gaps:	155/858 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    29 QEGQLGLVQQLLE--SSSDASGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKF 91
            :.|.|..|:::||  ..:|........|:.          |.||..||.            |..|
  Fly    41 ERGDLPGVKKILEEYQGTDKFNINCTDPMN----------RSALISAIE------------NENF 83

Mouse    92 DFR--------QIHEALLVAVDTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAP 148
            |..        ::.:|||.|:.......|..|   |:.|:....:.:.:|....|.|  .|.|..
  Fly    84 DLMVILLEHNIEVGDALLHAISEEYVEAVEEL---LQWEETNHKEGQPYSWEAVDRS--KSTFTV 143

Mouse   149 GVTPLTLACQKDLYEIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASR 213
            .:|||.||..::.|||.::|:|:|.|:..||.|.|.|.||..::..|.|:.|.||||.||.:::.
  Fly   144 DITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSAS 208

Mouse   214 AHLSLASEDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLND 278
            :.::|:|.|.:|.|||||.||:||...|.||:.:|..:..:.||:|..||...|...|:..:||.
  Fly   209 SLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNF 273

Mouse   279 LGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGSTT 343
            ..|.|.   :...|||.     ..|.||:||:.|.||.|||||..||:|::||...|.|:|....
  Fly   274 NHEPSH---DIWCLGQR-----QTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQA 330

Mouse   344 IWKLFVAFLIFLTMPFLCIGYWLAPKSQLGRLLKIPVLKFLLHSASYLWFLIFLLGESLVMETQL 408
            ..:|.....:..:.|...:.|.|||.|:..:.::.|.:||:.||.||::||: |||.:.:...|:
  Fly   331 SQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLM-LLGAASLRVVQI 394

Mouse   409 STF-------------------KGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWWNF 454
             ||                   :|......|.:: :.::...::.|.|.::.:||..|::|.||.
  Fly   395 -TFELLAFPWMLTMLEDWRKHERGSLPGPIELAI-ITYIMALIFEELKSLYSDGLFEYIMDLWNI 457

Mouse   455 LDVVILSLYLASFALRLLLAGLAYMHCRDASDSTTCRYFTTAERSEWRTEDPQFLAEVLFAVTSM 519
            :|.:....|:.....|  ......:| ||........||   .|..|...||..|:|..||...:
  Fly   458 VDYISNMFYVTWILCR--ATAWVIVH-RDLWFRGIDPYF---PREHWHPFDPMLLSEGAFAAGMV 516

Mouse   520 LSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCGLNNIYVPYQESEK----- 579
            .|:.:|.:|...:..||.||:|:|:||.|:|:|.||..::|.||.||||.:...|.|.||
  Fly   517 FSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYH 581

Mouse   580 --------------------LGNFNETFQFLFWTMFGMEEHTVVDMPQF------LVPEFVGRAM 618
                                ..|..||.|.|||..||:     ||:..|      ....|....|
  Fly   582 LHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGL-----VDLVSFDLAGIKSFTRFWALLM 641

Mouse   619 YGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKA 683
            :|.::::.:||||||||||::||:|.|.:.||.|||||||:|::|||.:|.|:|.|||:.|:.|
  Fly   642 FGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMK- 705

Mouse   684 AFYLVRRIFRFLCCGSSCCKAKKSDYPPIGTFTNPGARAGSAGEGERV-SYRLRVIKALVQRYIE 747
               ::|:                    .:|.......::......||. :...:|:|.||:|||
  Fly   706 ---MLRK--------------------TLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYI- 746

Mouse   748 TARREFEETRRKDLG---NRLTELTKTVSRLQSEVASVQKN---------LAAGGAPRPPDGASI 800
            ||    |:.||.|.|   :.:.|:.:.:|.|:.|:..:..|         ..:.|..|...| .:
  Fly   747 TA----EQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKG-KV 806

Mouse   801 LSRYITRVRNSFQ 813
            :.|   |:...||
  Fly   807 MER---RILKDFQ 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpc2	NP_001103367.1	trp	23..761	CDD:273311	249/792 (31%)
		ANK	63..>172	CDD:238125	31/116 (27%)
		ANK repeat	93..138	CDD:293786	9/52 (17%)
		ANK repeat	140..173	CDD:293786	13/32 (41%)
		TRP_2	183..242	CDD:285535	26/58 (45%)
trp	NP_476768.1	trp	16..776	CDD:273311	254/812 (31%)
		ANK	64..>168	CDD:238125	32/130 (25%)
		ANK repeat	69..98	CDD:293786	8/50 (16%)
		ANK repeat	99..135	CDD:293786	9/38 (24%)
		ANK repeat	137..168	CDD:293786	13/32 (41%)
		TRP_2	178..236	CDD:285535	26/57 (46%)
		BASP1	938..1158	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810