DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCER1A and unc-40

DIOPT Version :9

Sequence 1:	NP_001374209.1	Gene:	FCER1A / 2205	HGNCID:	3609	Length:	257	Species:	Homo sapiens
Sequence 2:	NP_491664.1	Gene:	unc-40 / 172233	WormBaseID:	WBGene00006776	Length:	1415	Species:	Caenorhabditis elegans

Alignment Length:	190	Identity:	42/190 - (22%)
Similarity:	78/190 - (41%)	Gaps:	28/190 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    76 SSLNIVNAKFEDSGEYKCQHQQVNES--EPVYLEVFS-DWLLLQASAEVVMEGQPLFLRCHGWRN 137
            ||:.:..|..||:|.|.|:....::|  ..|.:||.: ..:..:.:.:|.:|...:.|.|.....
Worm   298 SSILVSRASIEDTGLYTCRASNNDDSIDRAVSVEVRAPPRITTRPTTKVAVETADVELECGTAAA 362

Human   138 WDVYKVIYYKDGEAL---KYW-YENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNI-TVIKA 197
            ....:|.:||:|||:   :|: .|.:.:.|......|...|.|   :.:.|..||..:. .::.|
Worm   363 RPEARVNWYKNGEAIIGSEYFVIEPNRLRILGVVRADQAIYQC---IAENDVGSEQASAQLLVDA 424

Human   198 PREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN 257
            |...             ..|..:|:.:::...    |.::.|..|.|.:|....|..:.|
Worm   425 PDSS-------------SVAASSGVPMTSSAP----LGLRSTSSGSRFINVEWDPPVQRN 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCER1A	NP_001374209.1	Ig1_FcgammaR_like	30..108	CDD:409410	10/33 (30%)
		Ig strand B	47..51	CDD:409410
		Ig strand C	61..65	CDD:409410
		Ig strand E	76..80	CDD:409410	2/3 (67%)
		Ig strand F	90..95	CDD:409410	2/4 (50%)
		Ig strand G	101..104	CDD:409410	1/4 (25%)
		Ig2_FcgammaR_like	112..194	CDD:409411	19/86 (22%)
		Ig strand B	128..132	CDD:409411	1/3 (33%)
		Ig strand C	142..146	CDD:409411	1/3 (33%)
		Ig strand E	159..163	CDD:409411	0/3 (0%)
		Ig strand F	173..178	CDD:409411	2/4 (50%)
		Ig strand G	187..190	CDD:409411	2/2 (100%)
unc-40	NP_491664.1	I-set	42..130	CDD:254352
		Ig	43..142	CDD:299845
		I-set	149..236	CDD:254352
		Ig	158..237	CDD:299845
		IG_like	251..332	CDD:214653	10/33 (30%)
		IGc2	258..320	CDD:197706	8/21 (38%)
		I-set	336..422	CDD:254352	19/88 (22%)
		Ig	352..422	CDD:299845	17/72 (24%)
		FN3	441..529	CDD:238020	7/31 (23%)
		FN3	536..627	CDD:238020
		FN3	635..727	CDD:238020
		FN3	738..816	CDD:214495
		FN3	852..927	CDD:214495
		FN3	946..1038	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910