DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traip and nopo

DIOPT Version :9

Sequence 1:	NP_035764.2	Gene:	Traip / 22036	MGIID:	1096377	Length:	470	Species:	Mus musculus
Sequence 2:	NP_611305.1	Gene:	nopo / 37083	FlyBaseID:	FBgn0034314	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	109/471 - (23%)
Similarity:	208/471 - (44%)	Gaps:	79/471 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 CTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKKTIINKLFFDLAQEEE 71
            |.||::.|..:.:|.|..|||.||..||.||.:.  |:||||||.:...:.|. :::|:||..:.
  Fly     6 CVICAELFGQADEVFATVCGHMFHHNCLNQWLDR--SKTCPQCRNKCTTRNIF-RVYFNLANLDV 67

Mouse    72 NVLDAEFLKNELDSVKAQLSQKDREK---RDSQAIIDTLRDTLEERNATVESLQNALNKAEMLCS 133
            :.:|...|:.:||:  |.||.|..||   :|.|.|.| |::|.::...|:..|:..:.|.:.|.|
  Fly    68 SHIDVGSLQEQLDN--AMLSMKMVEKERNKDEQQIRD-LKETQKKCLKTIAGLEQKVQKKDFLIS 129

Mouse   134 TLKKQMKFLEQRQDETKQAREEAHRLKCKMKTMEQIELLLQSQRSEVEEMIRDMGVGQSAVEQLA 198
            :..:|:..|:.........|:|...||.::::||.|..:|.:..::.:.::::    ::....||
  Fly   130 SYVEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKN----EADPHVLA 190

Mouse   199 VYCVSLKKEYENLK----EARKATGELADRLKKDLVSSR---SKLKTLNTELDQAKLELRSAQKD 256
            .:..:||:|....:    |.|.....:.:.|:|::...|   .::..|.::|.||:.:|::.:..
  Fly   191 NWVSTLKRELRQCESKKTELRNVVKVVQNDLRKEIELKRKLEERVSHLESDLYQAQEKLQAFENK 255

Mouse   257 LQSADQEITS--LRKKLMIL---QGTLSLPPATNETVSRLVFESPAPVEMMNPRLHQPPFGDEID 316
            ....|....|  |...::.|   :...::.|...|.:.| :.||.:|.
  Fly   256 TAYLDSPNASCGLNSNILALKREERRTTISPTVKENIKR-IEESTSPY----------------- 302

Mouse   317 LNTTFDVNTPPTQTSGSQHCLPKK--LCLERAR-SPMQNVLKKVHKVSKPESQLSLGGQRCVGEL 378
            ||.       .:.:.|..|.|..|  :.|.::: ||::.|...|...|           ..:.:.
  Fly   303 LNI-------KSSSVGLAHLLNTKGNIGLAKSKISPIKGVGGGVSMTS-----------GTIRKT 349

Mouse   379 DEELAGAFPLFIR-NAVLGQKQPNRTTAESRCSTDVVRIGFDGLGGRTKFIQPRDTTIIRPVPVK 442
            ..:|:..:.:|.: ..:||....:..||     |......::|:||..|         :.|...:
  Fly   350 SSDLSEKYSIFKKPRLLLGSSSSSALTA-----TTGSNFVYNGMGGSEK---------VDPFAQR 400

Mouse   443 SKAKSKQKVRIKTVSS 458
            ::.:....:|..|..|
  Fly   401 AEEEGLSTIRSSTALS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traip	NP_035764.2	zf-RING_2	7..50	CDD:290367	20/42 (48%)
		BRE1	204..>271	CDD:285810	16/75 (21%)
		Interaction with CYLD. /evidence=ECO:0000250\|UniProtKB:Q9BWF2	211..470		47/264 (18%)
		PIP-box. /evidence=ECO:0000250\|UniProtKB:Q9BWF2	461..470
nopo	NP_611305.1	zf-RING_2	5..47	CDD:290367	20/42 (48%)
nopo	NP_611305.1	zf-rbx1	<5..47	CDD:289448	20/42 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11289
eggNOG	1	0.900	-	-		E1_KOG0827
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4938
Isobase	1	0.950	-	0	Normalized mean entropy	S5511
OMA	1	1.010	-	-		QHG50113
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006979
OrthoInspector	1	1.000	-	-		oto94169
orthoMCL	1	0.900	-	-		OOG6_107085
Panther	1	1.100	-	-	LDO	PTHR46569
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	1	1.000	-	-		X4425
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.810