Protein Alignment Traf6 and Traf4

DIOPT Version :9

• Sequence 1: NP_001290202.1
• Gene: Traf6 / 22034
• MGIID: 108072
• Length: 530
• Species: Mus musculus
• Sequence 2: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 122/535 - (22%)
• Similarity: 194/535 - (36%)
• Gaps: 114/535 - (21%)

Mouse    12 SSQSSSDCCAAMAASCSAAV----KDDSVSGSASTGNLSSSFMEEIQGYDVEFDPPLESKYECPI 72
            |...:|..|:.:|:......    |..|.||:.:|...|||.:............|..:....||
  Fly    19 SPNRNSKDCSTLASPVPPPTPPRNKTTSGSGNCATSRSSSSTVSSSHSSSHSSPTPGNNNNNMPI 83

Mouse    73 CLMALREAVQTPCGHRFCKACIIKSIRDAGHK--CPVDNEI-LLENQLFPDNFAKREILSLTVKC 134
              ..|.:.:......:.....::..|.   ||  |...:|: .|:..|   |..|.:    ..:|
  Fly    84 --TELEQIIYPGPDPKHIMGSLVFCIH---HKQGCKWSDELRKLKGHL---NACKHD----ATQC 136

Mouse   135 PNKGCLQKMELRHLEDH-QVHCEFALVNCPQCQRPFQ--------------------KC------ 172
            ||| |..::....:.|| |..|......|..||..|.                    ||
  Fly   137 PNK-CGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILR 200

Mouse   173 -QVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIIC-EYCGTILI-REQMPNHYDLD 234
             ::..|..:||.:|...|.:|....:.:...:|...||.|.:.| :.|....| |.::..|...:
  Fly   201 GRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLRDE 265

Mouse   235 CPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPE 299
            |.:..:.|:|...||..|..|..|..||:.|...|:.|:.
  Fly   266 CQSLAVSCSFKEAGCRFKGPRQMLEAHLESNAAAHLSLMV------------------------- 305

Mouse   300 DPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWK 364
                     .|.||..:|...::...:|:...  |.|.|                       :||
  Fly   306 ---------ALSSRQGQQIQMLKSAVSKLSIN--YTGTL-----------------------LWK 336

Mouse   365 IGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKL--CMRLHLQLPTAQRCANYISLFVHTMQGEYD 427
            |.::...:.....:..:.:.||.|||.:.||||  .|.|:...|...   .::|:::..:.||||
  Fly   337 ITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGEN---THVSVYIKVLPGEYD 398

Mouse   428 SHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQ 492
            :.|.|||..:|..|:.:|.....:....|.....|....||||:...:..|||:..|:..|.|..
  Fly   399 ALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHS 463

Mouse   493 GTFIKDDTLLVRCEV 507
            ..|||.||:.:|.:|
  Fly   464 RPFIKGDTVFLRVKV 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_001290202.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		76/386 (20%)
		RING	69..107	CDD:238093	7/39 (18%)
		zf-TRAF	204..261	CDD:280357	17/58 (29%)
		SlyX	304..>356	CDD:294687	8/51 (16%)
		MATH_TRAF6	359..508	CDD:239745	46/151 (30%)
		Interaction with TANK. /evidence=ECO:0000250|UniProtKB:Q9Y4K3	363..530		46/147 (31%)
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	23/104 (22%)
		zf-TRAF	233..292	CDD:424248	17/58 (29%)
		MATH_TRAF4	331..479	CDD:239750	48/174 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920