Protein Alignment Hsp90b1 and Hsp83

DIOPT Version :10

• Sequence 1: NP_035761.1
• Gene: Hsp90b1 / 22027
• MGIID: 98817
• Length: 802
• Species: Mus musculus
• Sequence 2: NP_523899.1
• Gene: Hsp83 / 38389
• FlyBaseID: FBgn0001233
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 350/729 - (48%)
• Similarity: 485/729 - (66%)
• Gaps: 31/729 - (4%)

Mouse    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67

Mouse   136 IKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200
            :..:|....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127

Mouse   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191

Mouse   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKE-------ESDD---EAAVEEEEEEK 319
            |.:|.|:||||.:||.:...|..  |:.:.:|||..|:||       |:|:   |...|:|:.:|
  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADK 254

Mouse   320 KPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGE 380
            |.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||:
  Fly   255 KDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQ 319

Mouse   381 VTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLN 445
            :.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:|||||
  Fly   320 LEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLN 382

Mouse   446 VSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAKL 509
            :|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||..
  Fly   383 ISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADF 447

Mouse   510 LRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574
            |||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:||
  Fly   448 LRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDE 512

Mouse   575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQR 639
            |.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.|
  Fly   513 YVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSNR 576

Mouse   640 LTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKED 704
            |.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...|
  Fly   577 LVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADAD 638

Mouse   705 EDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSED 769
            ::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|....
  Fly   639 KNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSL 703

Mouse   770 AEDSEQ-DEGEEMD 782
            .||:|. ...||:|
  Fly   704 VEDTEDASHMEEVD 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp90b1	NP_035761.1	SRT pseudosubstrate motif. /evidence=ECO:0000250|UniProtKB:P14625	42..44
		HATPase_Hsp90-like	83..275	CDD:340404	110/192 (57%)
		HSP90	257..775	CDD:459703	238/532 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..323		14/42 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	749..802		9/35 (26%)
		Prevents secretion from ER	799..802
Hsp83	NP_523899.1	HSP90	6..717	CDD:481033	348/724 (48%)