DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp90b1 and Hsp83

DIOPT Version :9

Sequence 1:	NP_035761.1	Gene:	Hsp90b1 / 22027	MGIID:	98817	Length:	802	Species:	Mus musculus
Sequence 2:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	350/729 - (48%)
Similarity:	485/729 - (66%)	Gaps:	31/729 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67

Mouse   136 IKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200
            :..:|....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127

Mouse   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191

Mouse   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKE-------ESDD---EAAVEEEEEEK 319
            |.:|.|:||||.:||.:...|..  |:.:.:|||..|:||       |:|:   |...|:|:.:|
  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADK 254

Mouse   320 KPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGE 380
            |.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||:
  Fly   255 KDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQ 319

Mouse   381 VTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLN 445
            :.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:|||||
  Fly   320 LEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLN 382

Mouse   446 VSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAKL 509
            :|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||..
  Fly   383 ISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADF 447

Mouse   510 LRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574
            |||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:||
  Fly   448 LRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDE 512

Mouse   575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQR 639
            |.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.|
  Fly   513 YVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSNR 576

Mouse   640 LTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKED 704
            |.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...|
  Fly   577 LVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADAD 638

Mouse   705 EDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSED 769
            ::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|....
  Fly   639 KNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSL 703

Mouse   770 AEDSEQ-DEGEEMD 782
            .||:|. ...||:|
  Fly   704 VEDTEDASHMEEVD 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp90b1	NP_035761.1	PRK05218	74..746	CDD:235366	338/687 (49%)
		HATPase_c	96..254	CDD:214643	93/158 (59%)
		HSP90	257..783	CDD:278607	242/542 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..323		14/42 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..802		9/35 (26%)
		Prevents secretion from ER	799..802
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	348/724 (48%)
		HATPase_c	28..179	CDD:214643	92/156 (59%)
		HSP90	184..706	CDD:278607	236/529 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710