DRSC/TRiP Functional Genomics Resources

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Protein Alignment FBN2 and frac

DIOPT Version :10

Sequence 1:NP_001990.2 Gene:FBN2 / 2201 HGNCID:3604 Length:2912 Species:Homo sapiens
Sequence 2:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:1427 Identity:381/1427 - (26%)
Similarity:520/1427 - (36%) Gaps:523/1427 - (36%)


- Green bases have known domain annotations that are detailed below.


Human  1069 PFYKDINECKAFPGMCTYGKCRNTI------GSFKCRCNSGFALDMEE-RNCTDIDECRISPDLC 1126
            |.:.| |.|....|.|.: .|:..:      ...||.|..|:.||..: .:|.|||||..|...|
  Fly   241 PTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGC 303

Human  1127 GSGICVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLL---CRGGTCVNTEGSFQCDC 1185
             |.||.|.||.::|.|.|||   |||    |:|:||:|| .||.|   |: |.|.|..||::|..
  Fly   304 -SEICENLPGEYKCSCQEGYYLDESG----KSCVDINEC-ANPELSSNCQ-GACENLPGSYRCVE 361

Human  1186 PLGHELSPSREDCVD-----INECSLSDNLCRN---GKCVNMIGTYQCSCNPGYQATPDRQGCTD 1242
            ||  |.:|...:.|:     .||..:  |:..:   ||          :||.|:|.:.|...|.|
  Fly   362 PL--EENPEITEVVENPIEKTNEVPV--NVSESQPAGK----------TCNSGFQLSADGTDCQD 412

Human  1243 IDECMI-------MNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN--NPDI----C 1294
            |:||.:       .|..|..:|.|:.||:.|:|.|||.|:.|.|||| :|.|.:  ||.:    |
  Fly   413 INECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRC 476

Human  1295 DGGQCTNIP-GEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSV 1358
             ..:|.::| |.|||:|..|:..|.|..:|: |.|          ..|...||            
  Fly   477 -AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE----------SPCSTEKG------------ 517

Human  1359 KKGTTGCTDVDECEIGAHNCDMHASCLNIPG--SFKCSCREGWIGNGIKCIDLDECSNGTHQCSI 1421
                     |::|..|        :||....  ||.|.|..|:......|.|:|||:..||.|| 
  Fly   518 ---------VEKCSPG--------TCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS- 564

Human  1422 NAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASD 1485
             ..|.||||.|:|.|.||.. .:.:||...:.|..|.|.||. .||...|.. |.|..||..::|
  Fly   565 -HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLSAD 626

Human  1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE---LDRTGGNCTDIDECADPINCVNGLC 1547
            .:||:|:|||...|......|.||||.:.|||..|||   ||...|.|.|||||:...:      
  Fly   627 GKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH------ 685

Human  1548 VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGK 1612
                                  ||                                         
  Fly   686 ----------------------GC----------------------------------------- 687

Human  1613 AWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCEC 1677
                                                                             
  Fly   688 ----------------------------------------------------------------- 687

Human  1678 PQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYR 1742
                   .|..:||:::                  |:|||:|||.|......|....:..||...
  Fly   688 -------SDQMLCENLN------------------GSYTCLCPPGYALGLDNHIVTSLNSSFITD 727

Human  1743 SYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
            |   |:.|                              ||..                 ||  .:
  Fly   728 S---TSSE------------------------------TPSA-----------------HT--CL 740

Human  1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
            |||||....|.|:: .|.|:.|.|:|.||.|::.::.:..|:|||||.:.:..|.:.  |:|.||
  Fly   741 DIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQL--CLNQPG 802

Human  1873 SYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVD 1936
            .:.|.|..||:|:|:| .|.|.:||.:....|| .:|::|.|::.|.|..|::.::|:..|:|||
  Fly   803 GFACACETGFELTPDGFGCADIDECSQDYGNCS-DICINLLGTHACACERGYELAKDKLSCLDVD 866

Human  1937 ECERHPCG--NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECS-SFFGQVCRNGRCFNEIGSFK 1998
            ||.....|  :..|.|..|::.|.|..|:.|   ||  |...|| :..|  |..|...:..|...
  Fly   867 ECAGLLSGGCSHECINKAGTFECGCPLGYIL---ND--DGRSCSPALVG--CPPGTQRSADGCAP 924

Human  1999 CLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINECD 2061
            ..||.||.|..|.| |:|.:||....|.|| ..|.|.||||:|.||||||:.|:  .|.||:|||
  Fly   925 IECNPGYTLGSDDK-CVDIDECQKQNGGCS-HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECD 987

Human  2062 EDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF--------------CFTNF---- 2108
            :|...|:.|:|.|..|||:|..|...||.:     ..|..|.              .||..    
  Fly   988 QDKTSCITGTCINEIGGFRCEFPKFPVLPE-----IPTASSLPESPKIELKTPKYPDFTELSNEI 1047

Human  2109 -ENGK------------CSVPK-----------AFNTTKAKC-CCSKMPGEGWGD---PCELCPK 2145
             ||.|            .|:||           ...|:||.. ...::|...|.:   |.:|||:
  Fly  1048 PENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPR 1112

Human  2146 DDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVR 2210
                 ||           :..:.:...|.......:....:|       |..|..||.|....::
  Fly  1113 -----FQ-----------APRNGKSHCNRYRHKQKLFYYSRC-------RISCNSGYILQGPEIK 1154

Human  2211 CVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTFGS 2274
                                     .|:.| |...||...|..||: .||:|             
  Fly  1155 -------------------------SCDAN-GIWEGPETKCVAINQPRAQSP------------- 1180

Human  2275 YECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339
                                                          .|||   |.:|...|.:..
  Fly  1181 ----------------------------------------------GICP---ALKPAQNGVILP 1196

Human  2340 NECRTKPG----ICENGRCVNIIGSYRCECNEGFQSSSS-GTECLDNRQGLCFAEVLQTICQ 2396
            ..|...|.    :|            |.:||.||.|:.| .|.|: ..||..|...|.  ||
  Fly  1197 ASCTQGPSRFGDVC------------RLQCNAGFVSTGSLLTACM-MLQGWSFGADLN--CQ 1243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FBN2NP_001990.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..52
Fibrillin_U_N 76..112 CDD:436338
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 149..359
TB 224..>257 CDD:459903
EGF_CA 276..306 CDD:429571
TB 373..417 CDD:459903
EGF_CA 535..565 CDD:214542
EGF_CA 575..616 CDD:214542
EGF_CA 617..657 CDD:214542
EGF_CA 658..698 CDD:214542
TB 713..756 CDD:459903
EGF_CA 768..809 CDD:214542
EGF_CA 810..845 CDD:238011
TB 906..>935 CDD:459903
EGF_CA 955..985 CDD:429571
TB 1010..1052 CDD:459903
EGF_CA 1115..1149 CDD:214542 19/36 (53%)
EGF_CA 1158..1190 CDD:214542 16/34 (47%)
EGF_CA 1200..1232 CDD:214542 8/39 (21%)
FXa_inhibition 1246..1281 CDD:464251 15/41 (37%)
EGF_3 1371..1406 CDD:463759 9/36 (25%)
EGF_3 1412..1447 CDD:463759 15/35 (43%)
EGF_CA 1491..1526 CDD:214542 18/37 (49%)
EGF_CA 1532..1563 CDD:214542 5/30 (17%)
TB 1593..1633 CDD:459903 0/39 (0%)
EGF_CA 1650..1691 CDD:214542 1/40 (3%)
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 1735..2171 145/487 (30%)
TB 1748..1791 CDD:459903 3/42 (7%)
EGF_CA 1808..1840 CDD:214542 15/31 (48%)
EGF_CA 1850..>1882 CDD:214542 12/31 (39%)
vWFA <1887..1929 CDD:469594 13/42 (31%)
EGF_CA 1934..1968 CDD:214542 13/35 (37%)
EGF_CA 1973..2015 CDD:214542 14/42 (33%)
EGF_CA 2016..2048 CDD:214542 17/31 (55%)
EGF_CA 2056..2096 CDD:214542 17/39 (44%)
TB 2111..2155 CDD:459903 15/70 (21%)
EGF_CA 2171..2212 CDD:214542 7/40 (18%)
EGF_CA 2213..2252 CDD:214542 5/38 (13%)
EGF_CA 2294..2326 CDD:473889 3/31 (10%)
TB <2405..2437 CDD:459903
EGF_CA 2449..2490 CDD:214542
FXa_inhibition 2495..2530 CDD:464251
EGF_CA 2532..2561 CDD:429571
EGF_CA 2614..>2643 CDD:214542
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 18/39 (46%)
cEGF 396..415 CDD:463661 8/18 (44%)
FXa_inhibition 425..458 CDD:464251 14/32 (44%)
FXa_inhibition 476..505 CDD:464251 11/29 (38%)
EGF_CA 552..>581 CDD:214542 16/30 (53%)
FXa_inhibition 596..630 CDD:464251 13/35 (37%)
FXa_inhibition 636..>664 CDD:464251 12/27 (44%)
EGF_CA 676..711 CDD:214542 18/193 (9%)
FXa_inhibition 745..780 CDD:464251 11/35 (31%)
FXa_inhibition 786..821 CDD:464251 13/36 (36%)
vWFA <821..861 CDD:469594 13/40 (33%)
FXa_inhibition 874..904 CDD:464251 11/34 (32%)
FXa_inhibition 945..980 CDD:464251 18/35 (51%)
PTZ00449 <1017..>1098 CDD:185628 14/85 (16%)
CCP 1110..1170 CDD:153056 16/108 (15%)
CCP 1183..1235 CDD:153056 19/67 (28%)
HYR 1468..1536 CDD:460572
Blue background indicates that the domain is not in the aligned region.

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