DRSC/TRiP Functional Genomics Resources

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Protein Alignment FBN2 and frac

DIOPT Version :9

Sequence 1:NP_001990.2 Gene:FBN2 / 2201 HGNCID:3604 Length:2912 Species:Homo sapiens
Sequence 2:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:1427 Identity:381/1427 - (26%)
Similarity:520/1427 - (36%) Gaps:523/1427 - (36%)


- Green bases have known domain annotations that are detailed below.


Human  1069 PFYKDINECKAFPGMCTYGKCRNTI------GSFKCRCNSGFALDMEE-RNCTDIDECRISPDLC 1126
            |.:.| |.|....|.|.: .|:..:      ...||.|..|:.||..: .:|.|||||..|...|
  Fly   241 PTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGC 303

Human  1127 GSGICVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLL---CRGGTCVNTEGSFQCDC 1185
             |.||.|.||.::|.|.|||   |||    |:|:||:|| .||.|   |: |.|.|..||::|..
  Fly   304 -SEICENLPGEYKCSCQEGYYLDESG----KSCVDINEC-ANPELSSNCQ-GACENLPGSYRCVE 361

Human  1186 PLGHELSPSREDCVD-----INECSLSDNLCRN---GKCVNMIGTYQCSCNPGYQATPDRQGCTD 1242
            ||  |.:|...:.|:     .||..:  |:..:   ||          :||.|:|.:.|...|.|
  Fly   362 PL--EENPEITEVVENPIEKTNEVPV--NVSESQPAGK----------TCNSGFQLSADGTDCQD 412

Human  1243 IDECMI-------MNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN--NPDI----C 1294
            |:||.:       .|..|..:|.|:.||:.|:|.|||.|:.|.|||| :|.|.:  ||.:    |
  Fly   413 INECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRC 476

Human  1295 DGGQCTNIP-GEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSV 1358
             ..:|.::| |.|||:|..|:..|.|..:|: |.|          ..|...||            
  Fly   477 -AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE----------SPCSTEKG------------ 517

Human  1359 KKGTTGCTDVDECEIGAHNCDMHASCLNIPG--SFKCSCREGWIGNGIKCIDLDECSNGTHQCSI 1421
                     |::|..|        :||....  ||.|.|..|:......|.|:|||:..||.|| 
  Fly   518 ---------VEKCSPG--------TCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS- 564

Human  1422 NAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASD 1485
             ..|.||||.|:|.|.||.. .:.:||...:.|..|.|.||. .||...|.. |.|..||..::|
  Fly   565 -HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLSAD 626

Human  1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE---LDRTGGNCTDIDECADPINCVNGLC 1547
            .:||:|:|||...|......|.||||.:.|||..|||   ||...|.|.|||||:...:      
  Fly   627 GKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH------ 685

Human  1548 VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGK 1612
                                  ||                                         
  Fly   686 ----------------------GC----------------------------------------- 687

Human  1613 AWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCEC 1677
                                                                             
  Fly   688 ----------------------------------------------------------------- 687

Human  1678 PQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYR 1742
                   .|..:||:::                  |:|||:|||.|......|....:..||...
  Fly   688 -------SDQMLCENLN------------------GSYTCLCPPGYALGLDNHIVTSLNSSFITD 727

Human  1743 SYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807
            |   |:.|                              ||..                 ||  .:
  Fly   728 S---TSSE------------------------------TPSA-----------------HT--CL 740

Human  1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
            |||||....|.|:: .|.|:.|.|:|.||.|::.::.:..|:|||||.:.:..|.:.  |:|.||
  Fly   741 DIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQL--CLNQPG 802

Human  1873 SYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVD 1936
            .:.|.|..||:|:|:| .|.|.:||.:....|| .:|::|.|::.|.|..|::.::|:..|:|||
  Fly   803 GFACACETGFELTPDGFGCADIDECSQDYGNCS-DICINLLGTHACACERGYELAKDKLSCLDVD 866

Human  1937 ECERHPCG--NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECS-SFFGQVCRNGRCFNEIGSFK 1998
            ||.....|  :..|.|..|::.|.|..|:.|   ||  |...|| :..|  |..|...:..|...
  Fly   867 ECAGLLSGGCSHECINKAGTFECGCPLGYIL---ND--DGRSCSPALVG--CPPGTQRSADGCAP 924

Human  1999 CLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINECD 2061
            ..||.||.|..|.| |:|.:||....|.|| ..|.|.||||:|.||||||:.|:  .|.||:|||
  Fly   925 IECNPGYTLGSDDK-CVDIDECQKQNGGCS-HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECD 987

Human  2062 EDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF--------------CFTNF---- 2108
            :|...|:.|:|.|..|||:|..|...||.:     ..|..|.              .||..    
  Fly   988 QDKTSCITGTCINEIGGFRCEFPKFPVLPE-----IPTASSLPESPKIELKTPKYPDFTELSNEI 1047

Human  2109 -ENGK------------CSVPK-----------AFNTTKAKC-CCSKMPGEGWGD---PCELCPK 2145
             ||.|            .|:||           ...|:||.. ...::|...|.:   |.:|||:
  Fly  1048 PENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPR 1112

Human  2146 DDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVR 2210
                 ||           :..:.:...|.......:....:|       |..|..||.|....::
  Fly  1113 -----FQ-----------APRNGKSHCNRYRHKQKLFYYSRC-------RISCNSGYILQGPEIK 1154

Human  2211 CVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTFGS 2274
                                     .|:.| |...||...|..||: .||:|             
  Fly  1155 -------------------------SCDAN-GIWEGPETKCVAINQPRAQSP------------- 1180

Human  2275 YECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339
                                                          .|||   |.:|...|.:..
  Fly  1181 ----------------------------------------------GICP---ALKPAQNGVILP 1196

Human  2340 NECRTKPG----ICENGRCVNIIGSYRCECNEGFQSSSS-GTECLDNRQGLCFAEVLQTICQ 2396
            ..|...|.    :|            |.:||.||.|:.| .|.|: ..||..|...|.  ||
  Fly  1197 ASCTQGPSRFGDVC------------RLQCNAGFVSTGSLLTACM-MLQGWSFGADLN--CQ 1243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FBN2NP_001990.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..52
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 149..359
TB 225..258 CDD:279073
EGF_CA 276..>306 CDD:214542
EGF_CA 318..358 CDD:284955
TB 375..412 CDD:279073
EGF_CA 535..565 CDD:214542
EGF_CA 575..616 CDD:214542
EGF_CA 617..649 CDD:238011
cEGF 638..661 CDD:289433
EGF_CA 658..698 CDD:214542
TB 715..751 CDD:279073
cEGF 790..813 CDD:289433
EGF_CA 810..845 CDD:238011
TB 907..>935 CDD:279073
TB 1012..1047 CDD:279073
EGF_CA 1115..1149 CDD:214542 19/36 (53%)
EGF_CA 1158..1190 CDD:214542 16/34 (47%)
EGF_CA 1200..1232 CDD:214542 8/39 (21%)
cEGF 1223..1245 CDD:289433 8/21 (38%)
FXa_inhibition 1246..1281 CDD:291342 15/41 (37%)
Plasmod_Pvs28 1293..1446 CDD:283826 46/160 (29%)
EGF_3 1371..1406 CDD:289699 9/36 (25%)
EGF_3 1412..1447 CDD:289699 15/35 (43%)
EGF_CA 1532..1563 CDD:214542 5/30 (17%)
TB 1593..1628 CDD:279073 0/34 (0%)
EGF_CA 1650..1683 CDD:238011 0/32 (0%)
cEGF 1672..1695 CDD:289433 3/22 (14%)
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 1735..2171 145/487 (30%)
TB 1749..1786 CDD:279073 3/36 (8%)
EGF_CA 1808..1840 CDD:214542 15/31 (48%)
vWFA <1847..1888 CDD:294047 17/40 (43%)
vWFA <1887..1929 CDD:294047 13/42 (31%)
EGF_CA 1934..1968 CDD:214542 13/35 (37%)
EGF_CA 1973..2015 CDD:214542 14/42 (33%)
EGF_CA 2056..2096 CDD:214542 17/39 (44%)
TB 2113..2150 CDD:279073 12/51 (24%)
EGF_CA 2171..2212 CDD:214542 7/40 (18%)
EGF_CA 2213..2252 CDD:214542 5/38 (13%)
vWFA <2251..2290 CDD:294047 6/39 (15%)
TB 2397..2432 CDD:279073 381/1427 (27%)
EGF_CA 2449..2490 CDD:214542
vWFA <2489..2529 CDD:294047
vWFA <2527..2563 CDD:294047
EGF_CA 2614..>2643 CDD:214542
Cadherin_repeat <2826..>2873 CDD:206637
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 18/39 (46%)
cEGF 396..415 CDD:289433 8/18 (44%)
FXa_inhibition 425..458 CDD:291342 14/32 (44%)
FXa_inhibition 476..505 CDD:291342 11/29 (38%)
vWFA <550..586 CDD:294047 19/37 (51%)
FXa_inhibition 596..630 CDD:291342 13/35 (37%)
FXa_inhibition 636..>664 CDD:291342 12/27 (44%)
EGF_CA 676..715 CDD:284955 18/197 (9%)
FXa_inhibition 745..780 CDD:291342 11/35 (31%)
FXa_inhibition 786..821 CDD:291342 13/36 (36%)
FXa_inhibition 827..862 CDD:291342 10/35 (29%)
FXa_inhibition 874..904 CDD:291342 11/34 (32%)
FXa_inhibition 945..980 CDD:291342 18/35 (51%)
CCP 1110..1170 CDD:153056 16/108 (15%)
CCP 1183..1235 CDD:153056 19/67 (28%)
DUF5011 1468..1536 CDD:295940
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100900
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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