DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VWCE and CSS1

DIOPT Version :9

Sequence 1:	NP_689931.2	Gene:	VWCE / 220001	HGNCID:	26487	Length:	955	Species:	Homo sapiens
Sequence 2:	NP_012097.1	Gene:	CSS1 / 854637	SGDID:	S000001431	Length:	995	Species:	Saccharomyces cerevisiae

Alignment Length:	345	Identity:	74/345 - (21%)
Similarity:	98/345 - (28%)	Gaps:	129/345 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   671 TYP---FHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPA 732
            |||   |...||...|..:.|.|.....:..::                               :
Yeast   366 TYPGTEFDISGENFDVTGNFNAEESAATSASIY-------------------------------S 399

Human   733 LLPGDCCSSCPDSLSPLEEKQG---LSPHGN---VAFSKA---GRSLHG-----DTEAPVNCSSC 783
            ..|....:|...|||..:.|:|   .||:.|   .:||.|   |.|:.|     |||..||..
Yeast   400 FTPSSFDNSGDISLSLSKSKKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQRRDDTEGSVNNG-- 462

Human   784 PGPPTASPSRPVLHLLQLLLRTNLMKTQTL----PTSPAGA----------HGPHSLALGLTATF 834
                                ..||....|.    |.|..|.          |.|.:.. |.|..|
Yeast   463 --------------------EINLDNGSTYVIVEPVSGKGTVNIISGNLYLHYPDTFT-GQTVVF 506

Human   835 PGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPE-------------------RSFS-AS 879
            .|| |.   |:..| |...|..:|:..........:|.:                   |.|| |.
Yeast   507 KGE-GV---LAVDP-TETNATPIPVVGYTGKNQIAITADITALSYDGTTGVLTATQGNRQFSFAI 566

Human   880 G---------------AQIVSRWPPLPGTLLTEASALSMMD-PSPSKTPITLLGPRVLSPTTSRL 928
            |               |...:.:....|.:.|.|::.|... .|.|.|..|..|..|   |.|..
Yeast   567 GTGFSSSDFSVSEGIFAGAYAYYLNYNGVVATSAASSSTASGASASVTGSTSFGASV---TGSTA 628

Human   929 STALAATTHPGPQQPPVGAS 948
            ||:..|:..........|||
Yeast   629 STSFGASVTGSTASTSFGAS 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VWCE	NP_689931.2	EGF_CA	142..180	CDD:214542
		cEGF	200..223	CDD:315355
		EGF_CA	220..262	CDD:214542
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..380
		VWC	386..440	CDD:327433
		VWC	501..559	CDD:327433
		VWC	572..625	CDD:214564
		VWC	629..684	CDD:327433	6/15 (40%)
		VWC	687..742	CDD:327433	3/54 (6%)
		Atrophin-1	<726..944	CDD:331285	62/281 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..889		24/125 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..955		14/47 (30%)
CSS1	NP_012097.1	Hyphal_reg_CWP	313..596	CDD:371712	57/288 (20%)
CSS1	NP_012097.1	PRK12355	627..>977	CDD:237072	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900