DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TPCN2 and para

DIOPT Version :9

Sequence 1:	NP_620714.2	Gene:	TPCN2 / 219931	HGNCID:	20820	Length:	752	Species:	Homo sapiens
Sequence 2:	NP_001259619.1	Gene:	para / 32619	FlyBaseID:	FBgn0285944	Length:	2145	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	144/704 - (20%)
Similarity:	248/704 - (35%)	Gaps:	239/704 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLLRPFF 194
            ::|..::.:|....|:..:..|.|.....|:::|||:::..||    .:...:.:|..|.|||..
  Fly  1344 VIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLR 1408

Human   195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG--KQDD------------ 245
            .:.....|:..:..:..::|.:.:|.|:..|...:|.:.|:.||||.  |.:|
  Fly  1409 AMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIP 1473

Human   246 ---GQDRERLTY------FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-------------- 287
               ..:.|..|:      |.::..:...|..:.|......:|..|......
  Fly  1474 NRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYL 1538

Human   288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFP 352
            |.:|||:|   ||.|.:||...:|...|.
  Fly  1539 YFVFFIIF---GSFFTLNLFIGVIIDNFN------------------------------------ 1564

Human   353 QAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP----P 413
                                       .:|.::.||:.:...|.||.:....:.:..:.|    |
  Fly  1565 ---------------------------EQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIP 1602

Human   414 RPEYQSPFLQSAQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGI 471
            ||.::.   |:..| :.....||           :.|.:|:.|:...:..:|.|      .:|..
  Fly  1603 RPRWRP---QAIVFEIVTDKKFD-----------IIIMLFIGLNMFTMTLDRYDASDTYNAVLDY 1653

Human   472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVG 536
            ||.:|:|.:..|.|||:|||... |...|.|:||    ||:::|.|                 :|
  Fly  1654 LNAIFVVIFSSECLLKIFALRYH-YFIEPWNLFD----VVVVILSI-----------------LG 1696

Human   537 LLSLWD----------MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI---LVV 588
            |: |.|          :.|::.:..|.|.||::...|   .:.:.:..|..::.|...|   |.:
  Fly  1697 LV-LSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAK---GIRTLLFALAMSLPALFNICLLLFL 1757

Human   589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
            |.::|||.|::.|..|......|.                    ..||..|..:::.|:.:....
  Fly  1758 VMFIFAIFGMSFFMHVKEKSGIND--------------------VYNFKTFGQSMILLFQMSTSA 1802

Human   654 NWQVFLDAY------------RRYSGPWSK----IYFVLWWLV-SSVIWVNLFLALILENF---- 697
            .|...|||.            :.|.|....    |.|:|.:|| |.:|.:|:::|:||||:
  Fly  1803 GWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQAT 1867

Human   698 ------------------LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
                              ..::||.       ||....|....|  |.|:||.|
  Fly  1868 EDVQEGLTDDDYDMYYEIWQQFDPE-------GTQYIRYDQLSE--FLDVLEPP 1912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPCN2	NP_620714.2	Ion_trans	<184..315	CDD:278921	36/167 (22%)
TPCN2	NP_620714.2	Ion_trans	468..697	CDD:278921	65/258 (25%)
para	NP_001259619.1	Ion_trans	165..436	CDD:278921
		Na_trans_cytopl	515..648	CDD:288761
		Ion_trans	835..1028	CDD:278921
		Na_trans_assoc	1054..1296	CDD:284034
		Ion_trans	1318..1571	CDD:278921	49/292 (17%)
		Na_channel_gate	1561..1613	CDD:240441	12/117 (10%)
		Ion_trans	1636..1871	CDD:278921	68/280 (24%)
		GPHH	1880..1930	CDD:293510	11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810