Protein Alignment TPCN2 and Ca-alpha1T

DIOPT Version :10

• Sequence 1: NP_620714.2
• Gene: TPCN2 / 219931
• HGNCID: 20820
• Length: 752
• Species: Homo sapiens
• Sequence 2: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Alignment Length: 799
• Identity: 154/799 - (19%)
• Similarity: 306/799 - (38%)
• Gaps: 230/799 - (28%)

Human    36 PGAAARWD---LCIDQAV--------------VFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQ 83
            ||...|:.   :.|:|..              :|.||. ::|.|      .:.::.::::.||
  Fly  2125 PGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDN-RFRQI------CTWFVNQKWFDNV-- 2180

Human    84 RTLSFTIFLILFLAF------IETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSV 142
                    ::||:|.      :|.|:...|:.:..:.|           :...:..:||..::.:
  Fly  2181 --------VLLFIALNCITLAMERPNIPPSSTERLFLA-----------TANYVFTVVFTVEMFI 2226

Human   143 K----GYLFGWAHFQKNLWLL--GYLVVLVVSLVDWTVSLSLVCHEP------LRIRRL---LRP 192
            |    |..:|...:..:.|.:  |.||  .:|::|  :.:||:....      ||:.||   |||
  Fly  2227 KVVATGMFYGHDAYFTSGWNIMDGSLV--TISIID--LLMSLISESSPRIFGILRVFRLLRSLRP 2287

Human   193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG-----------GKQDDG 246
            ..::..:..:|..::.:..||..:.::.|:......:|.:.|:.||.|           |.::..
  Fly  2288 LRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNAD 2352

Human   247 QDR--------ERLTYFQNLPESLTSLLVLLTTANNPDVMI-----------PAYSKNRAYAIFF 292
            :.|        .|...|.:|.::|.||.||.:.....::|.           |..:.|....::|
  Fly  2353 ECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYF 2417

Human   293 IVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGV 357
            |.|.::...|::|:...::...|.            |.|
  Fly  2418 IAFILLVGFFVLNMFVGVVVENFH------------RCR-------------------------- 2444

Human   358 KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
                             .:|...||:|......|..|:.::..:|         ||.....||..
  Fly  2445 -----------------EEQEKEEKIRRAAKRALQMEKKRRRMHE---------PPYYTNYSPTR 2483

Human   423 QSAQFLFGHYYFDYLGNLIALANLVSI-CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
            .....:....|||     :|:|.::.: .|.:.::...:|:.. .:.|.|.|..|...::||..:
  Fly  2484 MFVHNVVTSKYFD-----LAIAAVIGLNVVTMAMEYYKMPSGL-KYALKIFNYFFTAVFILEANM 2542

Human   487 KVFALGLRGYLSYPSNVFD---GLLTVVLLVL-EISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
            |:.|||.:.||....|..|   .||::|.:|| |:.|.....:|   ..|.::         |::
  Fly  2543 KLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIP---INPTII---------RVM 2595

Human   548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
            .:|.:.|.|:::.....:..:..||:..:..:...|.:..:::::||.:|:.||
  Fly  2596 RVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELF----------- 2649

Human   613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL------------DAYRR- 664
            .....:...||....:..::||    |..|.:||:.:...:||...:            |..|.
  Fly  2650 GRLECSDEIPCQGLGEHAHFAN----FGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNC 2710

Human   665 -YSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
             .|...:.|:||::.|::..:.||:.:|::::          ||:......|....|.|| |.|:
  Fly  2711 CVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMK----------HLEESHKQMEDELDMEVE-LERE 2764

Human   729 ILEE---PGEDELTERLSQ 744
            ::.|   ..|.:|.::|::
  Fly  2765 LVREQEFAQEQKLCQQLAE 2783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPCN2	NP_620714.2	Ion_trans	<184..315	CDD:459842	34/163 (21%)
		Interaction with phosphatidylinositol 3,5-bisphosphate. /evidence=ECO:0000269|PubMed:30860481	203..207		1/3 (33%)
		Ion_trans	431..697	CDD:459842	62/284 (22%)
Ca-alpha1T	NP_001259267.1	Ion_trans	300..636	CDD:459842
		Ion_trans	1243..1495	CDD:459842
		Ion_trans	2175..2448	CDD:459842	59/352 (17%)
		Ion_trans	2492..2728	CDD:459842	59/268 (22%)