Protein Alignment Tph1 and ple

DIOPT Version :9

• Sequence 1: NP_001129556.1
• Gene: Tph1 / 21990
• MGIID: 98796
• Length: 447
• Species: Mus musculus
• Sequence 2: NP_001286955.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 187/434 - (43%)
• Similarity: 288/434 - (66%)
• Gaps: 4/434 - (0%)

Mouse    10 ENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISRE 74
            |:.|..:......|:..|:..:..|.::||..:..|.::.|:|||:|:....:.::.:..|::|.
  Fly   148 ESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRG 212

Mouse    75 QLNDIFPLLKSHATVLSVDSPDQLTAKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGF 139
            .|..:...|:...:..|::    |.|..::....|||||..|:||.|.:.:..|..:||.:||||
  Fly   213 NLLQLIRSLRQSGSFSSMN----LMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGF 273

Mouse   140 KDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLS 204
            .|.|||:|||..||:|..||:|||||.|::::.|:|||.::|:.:..|.|.|||.||......|.
  Fly   274 ADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQ 338

Mouse   205 KYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTP 269
            ....:.|..:|||:::|:||::.||||:||.||.|:.||||:.||||:|..||||||.:.|.:||
  Fly   339 DEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTP 403

Mouse   270 EPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFG 334
            |||:.||||||:||||:||||||||||||||||||:|.::||:|.|:|||||||||:.||::.:|
  Fly   404 EPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYG 468

Mouse   335 AGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRP 399
            ||||||..||.||:|...:.:.|:|.....|......:|.:|:|:|||||||:|.|.:..|:.||
  Fly   469 AGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRP 533

Mouse   400 FGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALARVTR 443
            |.:::||:|:.|:||.....:.:.::::..::..:::|::::.|
  Fly   534 FEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tph1	NP_001129556.1	Trp_5_monoox	3..441	CDD:130337	186/430 (43%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	186/431 (43%)
		ACT	130..234	CDD:298841	19/89 (21%)
		Biopterin_H	243..573	CDD:278766	166/329 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810