DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FBLN2 and fbln2

DIOPT Version :9

Sequence 1:	NP_001004019.1	Gene:	FBLN2 / 2199	HGNCID:	3601	Length:	1231	Species:	Homo sapiens
Sequence 2:	XP_001341277.2	Gene:	fbln2 / 553503	ZFINID:	ZDB-GENE-060711-1	Length:	1408	Species:	Danio rerio

Alignment Length:	1423	Identity:	604/1423 - (42%)
Similarity:	783/1423 - (55%)	Gaps:	225/1423 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    14 LGLALALGPSVAAAAPRQDCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQYYDCLQGGF 78
            |.||..|  |::....::|||||:||.|:|||||.|:.|||||||||.||.|||||||||:..||
Zfish     6 LNLAFLL--SMSGCLGQKDCTGVDCPELQNCIEEVLDTGACCATCVQTGCMCEGYQYYDCISAGF 68

Human    79 VRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHAG 143
            ..|:|..|:||||||||||||||.|||:|||.|:.|||:|.||||....||.|.||.:|||||..
Zfish    69 RNGKVAEGESYFVDFGSTECSCPQGGGRISCHFIPCPEVPANCIELSEPADGCIQCERVGCVHKD 133

Human   144 HKYAAGHTVHLPPCRACHCPDAGGELICYQLPGCHGN----------FSDAEEGDPER------- 191
            .||.||||..:.||..||||:.||:|:||.:|.|:.:          ..:..:|.|.|
Zfish   134 QKYEAGHTFQIDPCEVCHCPNGGGDLMCYPVPSCNPSRASKPMLMTTTEETTQGMPYRDPIMHIF 198

Human   192 -----------HY---------------------EDPYSYDQEVAEVEAAT----ALGGEVQAGA 220
                       |:                     ||...||....:..|.:    |...|....:
Zfish   199 NNQGSRIPFTKHFPLHANNNRPFKLHMRKIDEKEEDEEDYDYPPTDYSAPSHDDFAAPTESSIMS 263

Human   221 VQAGAGGPP--AALGGGSQPL--------STIQAPPWPAV---LPRPTAAAALGPP-----APVQ 267
            |.......|  ....|..|.|        ||.:.|.:|..   ..|.........|     :|::
Zfish   264 VSRSDNFTPHQGVHRGAKQELREMLGIHRSTTERPQFPFYKDSTDRMRVGTRNDKPKNELFSPLE 328

Human   268 AKARR-------------------------------------------------VTEDSEEEEEE 283
            .|..|                                                 .|.|.|.:..:
Zfish   329 YKTDRERFILPVETTNRLGFSSHKDASEIHSFSLYKDSFNQEALTDDEQLEFPSETTDGERDTSQ 393

Human   284 EEEREEMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPE-ENLILDAQAT 347
            |:......||:.            |.|.....|.|:.|......|..:.|:..: ..|..:...|
Zfish   394 EDTTYSKTVTDS------------PVTIEKTTSSPLWETTISMQAAWDVGSESQIRKLFPNTVET 446

Human   348 SRSTGPEGVTHAPSLGKAALV-PTQAVPG-------------SPRDPVKPSPHNILSTSLPD--- 395
            ..|...|.:|...|..|||:: .|.::.|             |..||.|.|. .|.:.:||:
Zfish   447 DGSKHEETITRESSKEKAAVLNETTSLYGFRSITGDQNEYILSTPDPAKQSV-TIPAETLPEHEE 510

Human   396 -AAWIPPT--------REVPRKPQVLP--------HSHVEED----------------------- 420
             .|.:...        ||.|...:.||        |...||:
Zfish   511 SVAEVEDEHKRLAVNHREPPEDHKQLPVKNTKPLEHPKPEEEHVQSTSAKHNTELERKHQWHLFS 575

Human   421 ------TDPNS---VHSIPRSSPEGSTKD------------LIETCCAAGQQWAIDNDECLEIPE 464
                  |.|.|   .||:.....|....|            |:|:||.|||:||.:|.:|..:..
Zfish   576 PVTFSPTSPPSNKQSHSLFNFREEEDEADNTLRAAFVDEQGLVESCCVAGQKWAEENQQCNRMAV 640

Human   465 SGTED--NVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLR 527
            . |||  :||...|:.||...|:|..|.||::.||.|..| ..::..||......||:||.||||
Zfish   641 K-TEDISSVCGVVQQQCCSGALRESRCQAGIIAAKAGRAC-QRNSPLCGEDSQTDCCNCCALGLR 703

Human   528 VRAEGQSCESNPNLGYPCNHVMLSCCE-GEEPLIVPEVRRP--PEPAAAPRRVSEAEMAGREALS 589
            :|.||:.||::..|.|||.||.|:||| .||.|.:|.:::.  |:|.|.|:|||:::. .::|||
Zfish   704 LRREGKGCEAHQYLSYPCGHVFLTCCEDAEEGLPLPTIKKKQRPQPTALPKRVSDSQF-WKQALS 767

Human   590 LGTEAELPNSLPG-DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQP 653
            .|......|||.. :..|.|... ..||.|.||||..||.|||.||::|..||.||..|......
Zfish   768 AGDVDPAVNSLEDLEHGDRCQRF-ASLCHHTCINTRDSYLCACHPGYTLLQDGHTCVSENQEEDN 831

Human   654 EAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE 718
            ...:|..:.:........|..:|:.. |.|..||.|.|.|:.|...|.||||||:.:..||.:||
Zfish   832 RVSEEDRIPTTVPDKQQTTTQMPVLH-NPCAGNGLCSQKCTVVQELAQCSCFPGFFLKPDGHTCE 895

Human   719 DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHC 783
            |.:|||.|.|:||..:.|.|..||:.|.....:|..|:|...:|.|||:|||||:.|||...|.|
Zfish   896 DVNECLNGRHNCSLDEVCKNHEGSYQCERVNEMCHKGFIHKHNRDCVDVNECVTNTHTCRADERC 960

Human   784 VNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 848
            ||::|.|.|.:.:.|..||.|::|.|||:|||.:.||.|..||.||||.|||.|:.:|||:.||.
Zfish   961 VNSVGGFVCERMILCSSGYQLRNGVCEDIDECVIRTHNCGMGFQCQNTDGSFTCKPKQRCLTGFT 1025

Human   849 QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGV 913
            ||..|||:||:||:|:.|||..||:||||||||||||..::|:||||:|.||.:|:||:||:||.
Zfish  1026 QDSHGNCIDIDECSSVREPCTTGFNCINTVGSYTCQRKIIMCSRGYHSSPDGARCIDVDECQTGT 1090

Human   914 HRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASG 978
            |||||||:|||||||:||||:.|:|.|...:.|:||||||..|||||..|||||.|||:|||.:|
Zfish  1091 HRCGEGQICHNLPGSHRCDCQTGYQYDTIRQLCVDVNECWRYPGRLCAQTCENTPGSYQCSCTTG 1155

Human   979 FLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTF 1043
            |.||.|||.|||:|||::..|||||||||||||||||.||.|.||||||.|||||:|..|.||.|
Zfish  1156 FSLAFDGKNCEDINECDSNPCSQECANIYGSYQCYCRAGYYLKEDGHTCEDIDECSQSIGNLCAF 1220

Human  1044 RCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYV 1108
            .|:||||||.||||..||:|:||||:|:|:||||:|:||||.::||.||||.||||.||||.||.
Zfish  1221 ECVNVPGSYTCACPPHGYSMSANGRTCQDIDECAIGSHNCSASQTCFNIQGGFRCLLFECPDNYR 1285

Human  1109 QVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNE 1173
            :||..:|||.:|.::.:||..|.|||:|||:|||.:::||.||||||:||::||.|.::|.:|||
Zfish  1286 RVSDIRCERMSCPNYQQCQTMPLRITYYQLSFQTNIVIPAQIFRIGPSPAYSGDNIIISIPRGNE 1350

Human  1174 EGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL 1231
            :|||.||:||::||.|||.|.|.|||||.:||||||.|||:.|||||::::|.|..::
Zfish  1351 DGYFSTRKLNSFTGAVYLHRQVREPRDFFIDVEMKLLRQGTFTTFLARIYVFITASSM 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBLN2	NP_001004019.1	ANATO	430..490	CDD:237984	23/73 (32%)
		ANATO	515..563	CDD:237984	26/48 (54%)
		FXa_inhibition	616..644	CDD:291342	16/27 (59%)
		vWFA	<717..759	CDD:294047	18/41 (44%)
		EGF_CA	766..>802	CDD:214542	17/35 (49%)
		EGF_CA	811..855	CDD:284955	25/43 (58%)
		EGF_CA	857..904	CDD:214542	30/46 (65%)
		EGF_CA	905..947	CDD:214542	27/41 (66%)
		vWFA	<946..986	CDD:294047	28/39 (72%)
		cEGF	970..993	CDD:289433	15/22 (68%)
		cEGF	1009..1032	CDD:289433	18/22 (82%)
		cEGF	1051..1075	CDD:289433	15/23 (65%)
		EGF_CA	1072..1120	CDD:284955	31/47 (66%)
fbln2	XP_001341277.2	ANATO	694..734	CDD:294031	23/39 (59%)
		FXa_inhibition	794..822	CDD:291342	16/27 (59%)
		cEGF	878..899	CDD:289433	11/20 (55%)
		EGF_CA	896..>922	CDD:304395	12/25 (48%)
		EGF_CA	943..>980	CDD:284955	18/36 (50%)
		EGF_CA	988..1032	CDD:304395	25/43 (58%)
		EGF_CA	1034..1081	CDD:214542	30/46 (65%)
		EGF_CA	1082..1115	CDD:214542	25/32 (78%)
		vWFA	<1116..1164	CDD:294047	30/47 (64%)
		cEGF	1147..1170	CDD:289433	15/22 (68%)
		cEGF	1186..1209	CDD:289433	18/22 (82%)
		cEGF	1228..1252	CDD:289433	15/23 (65%)
		EGF_CA	1249..>1285	CDD:284955	25/35 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339449
Domainoid	1	1.000	147	1.000	Domainoid score	I18288
eggNOG	1	0.900	-	-		E33208_3BC1W
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1514
Inparanoid	1	1.050	1054	1.000	Inparanoid score	I2077
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39854
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	1	1.000	-	-		FOG0012082
OrthoInspector	1	1.000	-	-		oto51698
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	1	1.100	-	-	LDO	PTHR24039
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300