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Protein Alignment Top1 and Top1

DIOPT Version :9

Sequence 1:	NP_033434.2	Gene:	Top1 / 21969	MGIID:	98788	Length:	767	Species:	Mus musculus
Sequence 2:	NP_001014742.1	Gene:	Top1 / 32458	FlyBaseID:	FBgn0004924	Length:	974	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	473/962 - (49%)
Similarity:	571/962 - (59%)	Gaps:	224/962 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 HLHNDSQIEADFRLNDSHKH----KDKHKDREHRH---------KEHK-KDKDKDREKSKHSNSE 55
            |.|:.|.       :.|.||    ||||:|||..|         |||| ..:||||.||..|:|:
  Fly    38 HHHSSSS-------SSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSK 95

Mouse    56 HKDSEKKHKEKEKTKHKDGSSEKHKDK--------------HK--DRDKERRKEEKIRAAGDAKI 104
            |:|.:|: ::.....|:.|||..||||              ||  .:|||||.::|.|.:..:..
  Fly    96 HRDKDKE-RDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSR 159

Mouse   105 KK------EKENG---------------------FSSPPRIKDEPEDDGYFAPP----------- 131
            .|      :||..                     .||....||:|..||.|..|
  Fly   160 HKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSG 224

Mouse   132 ----------------------------------------------------------------- 131

  Fly   225 SVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMS 289

Mouse   132 ---------------------------------------KEDIKPLKRLR------------DED 145
                                                   :||:....|.|            |.|
  Fly   290 QFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDND 354

Mouse   146 DADYKP----KKIKTEDIKKEKKRKS------EEEEDGKLKKPKNKDKDKKVAEP-----DNKKK 195
            |.|..|    ||:|.|.||||.|.||      |..:|....|||.| |.||..||     ..:|.
  Fly   355 DDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNVKPKKK-KMKKEPEPAVSPGKRQKA 418

Mouse   196 KPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVAT 260
            |.|.|||:.|:|||||:..:|:||..||||||||||.||.:|.:|:||||||.::||.:.||.||
  Fly   419 KAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAAT 483

Mouse   261 FFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEE 325
            |:||||:|:|.|||:|..|||||:||.||..|:..|.:..||:|.:|..||:|:||.||..||||
  Fly   484 FYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKEE 548

Mouse   326 KLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSK 390
            ||..|.|||.|:||:|||::|.|:|:|.||::||||||||||.||||||:||||...|:.|||.|
  Fly   549 KLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGK 613

Mouse   391 DAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKC 455
            |:||||||||.:||||||||.||||.||.||:||.:|||||||||::|||||..||||||||.|.
  Fly   614 DSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDKV 678

Mouse   456 VDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPEL 520
            :||||..||::||||||:||||||||||||||||||||||:| :.|||||||||||||:.||.||
  Fly   679 IDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKEL 742

Mouse   521 DGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEG 585
            :|:|.||.|||||||||||||:|.|||||||||:||||:|:..|||||||||.:||:||::||||
  Fly   743 NGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELMEG 807

Mouse   586 LTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQ 650
            ||||||||||||.|||.||..||.|...||.|:|:||||||||||||||||:.||:.||||.||:
  Fly   808 LTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENLK 872

Mouse   651 SKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQ 715
            .||.||::.:.....:..|        :|       |.|.|.::||.:||.|||:|.|||:|||.
  Fly   873 EKIKAKREAIEKCESEYHS--------RD-------EKKGKQLERLRDQLKKLELQETDRDENKT 922

Mouse   716 IALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF 767
            |||||||||||||||:||||||..||||||:|||||.||.||:.|.||:|.|
  Fly   923 IALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.