DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tns1 and Pten

DIOPT Version :9

Sequence 1:	XP_006495930.2	Gene:	Tns1 / 21961	MGIID:	104552	Length:	1922	Species:	Mus musculus
Sequence 2:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	127/479 - (26%)
Similarity:	207/479 - (43%)	Gaps:	96/479 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse   180 RAMEDSCELDLVYVTERIIAVSFPSTANEEN-FRSNLREVAQMLKSKHGGNYLLFNL-SEQRPDI 242
            |..|...:|||.|:.:.|||:.:|:....|. ||:.|.:|.::|:..|..:|.::|| ||:..|:
  Fly    22 RYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDV 86

Mouse   243 TKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSN 307
            .|...:|..:.:.|.:.|.:|.|...|..:|.||..|..|||.:|.|..:||.|.:|.|||.:|.
  Fly    87 AKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSG 151

Mouse   308 ISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNF 372
            |..|||:||..:..||..:.|.|.|  |||||||.|||.|:..|:..:...|.:..:..
  Fly   152 IKKSADEALAWYDEKRTKDRKGVTI--PSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRF------ 208

Mouse   373 ESKGGCRPFLRIYQ-AMQPVYTSGIYN--------IPGDSQASICITIEPGLLLKGDILLKCYHK 428
             |:..|...|.:.: ::..::.|...|        :|.|.|.|..:||:|.:.:.||:..:...|
  Fly   209 -SESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKK 272

Mouse   429 KFRSPAR-------DVIFRVQFHTCA--------IHDLGVVFGKEDLDEAFKDD---RFPDYGKV 475
               ||.:       :..|...:..|.        ||.|    .|.::|:..||.   ||.:..|:
  Fly   273 ---SPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTL----SKSEIDDVHKDSEHKRFSEEFKI 330

Mouse   476 EFVF----------SYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHREDGMEGLKV 530
            ..||          :...||    |..||    .:::..||       ||:
  Fly   331 SIVFEAENFSNDVQAEASEK----ERNEN----VLNFERSD-------YDS-------------- 366

Mouse   531 VGHTQGPLDGSLYAKVKKKDSLNGSSGPVTTARPALSATPNHVEHTLSVSSDSGNSTASTKTDKT 595
                   |..:.||:.|...::...:    |.:.....|.:|.:....:..|:..::.:|.|...
  Fly   367 -------LSPNCYAEKKVLTAIVNDN----TTKSQTIETLDHKDIVTKIQYDTSTNSKNTSTACK 420

Mouse   596 DEPVSGATTAPAALSPQEKKELDR 619
            .:..:..|..| :|:...|:|:.|
  Fly   421 RKQPNSKTLLP-SLNDSTKEEIKR 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tns1	XP_006495930.2	C1	<79..112	CDD:381770
		PTP_DSP_cys	189..347	CDD:391942	65/159 (41%)
		PTEN_C2	354..480	CDD:371036	32/162 (20%)
		PHA03247	<737..1233	CDD:223021
		PHA03247	<1073..1649	CDD:223021
		SH2_Tensin_like	1646..1761	CDD:198181
		PTB_tensin	1783..1916	CDD:269924
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	40/108 (37%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	31/152 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810