DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAT2 and CadN2

DIOPT Version :9

Sequence 1:NP_001438.1 Gene:FAT2 / 2196 HGNCID:3596 Length:4349 Species:Homo sapiens
Sequence 2:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster


Alignment Length:1978 Identity:394/1978 - (19%)
Similarity:629/1978 - (31%) Gaps:757/1978 - (38%)


- Green bases have known domain annotations that are detailed below.


Human  2571 VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIE 2635
            |:|.:.|:||:||.|....|...|..|....|.|:.|.|.|.:|..|                  
  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN------------------ 68

Human  2636 INPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSA 2700
                                                     :|.|:.                  
  Fly    69 -----------------------------------------IRYQIT------------------ 74

Human  2701 PEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQI 2765
                  |..||                          ..|::...||||.|..|:|:|:...|::
  Fly    75 ------GGNIG--------------------------NAFAVQNTTGVIYVASPLDYETRPRYEL 107

Human  2766 DVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTE----NMPVGTSVIQVTAIDKDT 2826
            .:.|...:..:..::|   |.|.|||||.|||:...|:..:||    |:|  ..::||||.|.|.
  Fly   108 RLEATRNRKNNYTTVV---INVRDVNDNPPVFDRQTYRTQITEEDDRNLP--KRILQVTATDGDV 167

Human  2827 GRDGQVSYRLSA---DPGSNVHELFAIDSESGWITTLQELDCETCQ---TYHFHVVAYDHGQTIQ 2885
            .|...:.|.|:.   ||.:..:..|.|:..:|.|..|:.||.:...   .:.|.|.|.|.|.. .
  Fly   168 DRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGE-G 231

Human  2886 LSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGD 2950
            |...|.:||::.|.|||||:|....|.|:|.||...|..|.|:..:|.|               |
  Fly   232 LVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYD---------------D 281

Human  2951 PLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLL 3015
            |                                                                
  Fly   282 P---------------------------------------------------------------- 282

Human  3016 YTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL------HGPGAHEFKLDPHTGEL-TTLTAL 3073
                                   :..|||::.||:      ...||..|:::|.||.: |.:..|
  Fly   283 -----------------------NESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCL 324

Human  3074 DRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTT----VKTPVAV 3134
            ||||...:::...|.||||.......::.|:|:||..|:|........| |.|.    .:||:..
  Fly   325 DRERTPDYSIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEV-DETNGTYIPETPILT 388

Human  3135 VFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
            |..:|.|: .|......:|:|..|                      |.....||..|        
  Fly   389 VTVQDEDE-TNTFQYKVVPNSGFG----------------------ADKFAMVRNGD-------- 422

Human  3200 TLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRV-VSGNEQGR 3263
              ||.::.::...||              ||.                .:.:|:|. :..|::|.
  Fly   423 --GTGSLKIIQPLDY--------------EDP----------------LQSSGFRFRIQVNDKGD 455

Human  3264 FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYST 3328
               |...|            |.||.::             .:.|:|.:.|:|::.|:|.::....
  Fly   456 ---DGPGG------------SDKYHVA-------------YSWVVVKLRDINDNVPKFDREHIEV 492

Human  3329 RVLENALVGDVILTVSATDEDGPLNSDITYSLI-GGNQLGHFTIHPKKGELQVAKALDREQASSY 3392
            .:.|:..||.::....|||.|...:|.:.|.:: ..|:...|.| ..:|.:.:.:.||||....:
  Fly   493 SIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRH 556

Human  3393 SLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDS-- 3455
            .:::.|.|.|.|.......:.:.|.|||||.|.|.| :|..|:.||.. |.|:|::...|||.  
  Fly   557 HIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQ-DYKPTLPENVS-GKKILEVAAKDPDDRL 619

Human  3456 PENGPPYSFRI-----------------TKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQA 3503
            ..||.|::||:                 .:|:|.:...:     :.:.....|.||:.|.:.|:.
  Fly   620 RGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAI-----ISSLRPFDREAQKSYAIPIEI 679

Human  3504 SDSGIPPLSSLTSVRVHV--TEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTY 3566
            .|:|.|.::..:::.|.:  ...:...|.:..:.::...|:.  |...:|:::..|.|..|....
  Fly   680 KDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQS--QDTPIGRVYVNDPDDWDVPDK 742

Human  3567 SLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSD---GTFTTTAGVHVYVWHVGQEALQ 3628
            ....|....:.|.:....|.:....|..||.|.....|.|   |.....|.:.|.|..:..||:|
  Fly   743 KYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQ 807

Human  3629 QAMWMGFYQLTPEELVSDHWR---------NLQRF---LSHKLDIKRANIHLASLQPAEAVAGVD 3681
            ||..|....:|.|:.|.. |.         .|:||   |:..|...|.|:.:.|:|..|......
  Fly   808 QAGSMRLSHITDEDFVRT-WNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPL 871

Human  3682 VLLVFEGHSGT---FYEFQELASIITHSAKEMEHSVGVQMRSAMPMVPC--QGP-TCQGQICHNT 3740
            ..:.|...|.|   :::...|..::....:|:|..||:.: :.:.:..|  :|. .|....|.:.
  Fly   872 TDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNI-TMVNINECLHEGKGKCGSNSCTSK 935

Human  3741 VHLDPKVGP-TYSTARLSILTPRHHLQRSCSCNGTATRFSGQSY--------------------- 3783
            |.|..|  | |.|..|.:::..|..:...|.|.  |..|:.|.:                     
  Fly   936 VELGKK--PYTVSVNRTALVGVRLDISAQCVCR--ARNFTHQDHNCRTHLCYNGGRCVETRNGPK 996

Human  3784 -----VRYRAPAARN-----------W----------HIHFYLKTLQPQAILLFT--------NE 3814
                 |.|..|..:.           |          |:.....|.....::|:.        .|
  Fly   997 CVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEE 1061

Human  3815 TA---SVSLKLASGVPQLEYHCLGGFYGN------LSSQRHVNDHEWHSILVEEMDASIRLMVDS 3870
            |.   .::|:|..|.|:|...     :|:      :.:::.::|..||.:.:.....::|::|| 
  Fly  1062 TVISDFIALELEQGYPRLLID-----FGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVD- 1120

Human  3871 MGNTSLV---------------------VPENCRGLRPERHLLLGGLILLHSSSNV--------S 3906
            ...|:||                     :|.....|...:.|.||||...|....:        |
  Fly  1121 FCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSS 1185

Human  3907 QGFEGCLDAVVVNEEALDLLAP-----------------------------GKTVAGLLETQ--- 3939
            :||:||:..|:.|.|..||..|                             |..||.|::.:   
  Fly  1186 KGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQAKCHC 1250

Human  3940 --------------------------AL--------TQCCL------------------HSDYC- 3951
                                      ||        ||..|                  |.:|. 
  Fly  1251 QPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAI 1315

Human  3952 ------------SQNTCLN---------------------------------------------- 3958
                        :.|:..|                                              
  Fly  1316 LELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGESRRYNESFH 1380

Human  3959 -----------------GGKCSWTH------GAGYVCKC-------------PPQFSGKH----- 3982
                             |||..:|.      .:.:...|             ||..:|..     
  Fly  1381 FTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQAT 1445

Human  3983 ------------------------------------CEQG------------RENCTFAPCLEGG 3999
                                                |.:|            |..|...|||.|.
  Fly  1446 MARNLERNCPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKGCVDRNECLDLPCLNGA 1510

Human  4000 TCI-LSPK-GASCNCPHPYTGDRCEMEARGCSEGHCLVTPEIQRGDWGQQELLIITVAVAFIIIS 4062
            ||| |.|: ...|.||..|.|:.||:    ..||..|   ::..|..|       .:.|..|||.
  Fly  1511 TCINLEPRLRYRCICPEGYWGENCEL----VQEGQRL---KLSMGALG-------AIFVCLIIIL 1561

Human  4063 TVGLLF--YCRRCKSHKPVAMEDPDLLARSV-------GVDTQAMPAIELNPLSASSCNNLNQPE 4118
            .:.|:|  |.|:.|:.|......|:...|..       |.....|.|.::.||..........|:
  Fly  1562 ILALIFVLYSRKRKTTKKKKRSGPEKDVRETVISYEDEGGGEDDMTAFDITPLQIPISAQGGPPD 1626

Human  4119 PSKASVPNELVTFGPNSKQRPVVCSVPP 4146
            .:...:|   :.:       ||:..:||
  Fly  1627 IAACKMP---IIY-------PVMTLLPP 1644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAT2NP_001438.1 Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..659 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1038..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1453..1551 CDD:206637
Cadherin_repeat 1559..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1762..1867 CDD:206637
Cadherin_repeat 1887..1963 CDD:206637
Cadherin_repeat <1998..2066 CDD:206637
Cadherin_repeat 2074..2163 CDD:206637
Cadherin_repeat 2176..2268 CDD:206637
Cadherin_repeat 2276..2375 CDD:206637
Cadherin_repeat 2383..2475 CDD:206637
Cadherin_repeat 2486..2581 CDD:206637 4/9 (44%)
Cadherin_repeat 2589..2682 CDD:206637 12/92 (13%)
Cadherin_repeat 2696..2793 CDD:206637 20/96 (21%)
Cadherin_repeat 2801..2902 CDD:206637 34/110 (31%)
Cadherin_repeat 2910..3007 CDD:206637 12/96 (13%)
Cadherin_repeat 3016..3109 CDD:206637 25/99 (25%)
Cadherin_repeat 3120..3209 CDD:206637 18/92 (20%)
Cadherin_repeat 3224..3317 CDD:206637 15/93 (16%)
Cadherin_repeat 3325..3422 CDD:206637 25/97 (26%)
Cadherin_repeat 3431..3522 CDD:206637 26/111 (23%)
Cadherin_repeat 3535..3619 CDD:206637 18/86 (21%)
Laminin_G_2 3800..3921 CDD:280389 34/166 (20%)
EGF_CA 3949..3984 CDD:238011 11/170 (6%)
Cadherin_repeat 37..143 CDD:206637
Cadherin_repeat 152..247 CDD:206637
Cadherin_repeat 366..454 CDD:206637
EGF 3990..4020 CDD:278437 15/31 (48%)
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 32/202 (16%)
Cadherin_repeat 140..248 CDD:206637 34/110 (31%)
Cadherin_repeat 256..359 CDD:206637 36/204 (18%)
Cadherin_repeat 379..481 CDD:206637 32/192 (17%)
Cadherin_repeat 489..586 CDD:206637 25/97 (26%)
Cadherin_repeat 594..703 CDD:206637 26/114 (23%)
Cadherin_repeat 724..801 CDD:206637 17/76 (22%)
EGF_CA 977..1010 CDD:238011 3/32 (9%)
LamG 1013..1198 CDD:238058 35/190 (18%)
EGF_2 <1233..1259 CDD:285248 4/25 (16%)
Laminin_G_2 1293..1428 CDD:280389 9/134 (7%)
EGF_CA 1497..1535 CDD:238011 16/37 (43%)
Cadherin_C 1583..1719 CDD:279398 13/72 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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