DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FAT1 and CadN2

DIOPT Version :9

Sequence 1:XP_005262891.1 Gene:FAT1 / 2195 HGNCID:3595 Length:4600 Species:Homo sapiens
Sequence 2:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster


Alignment Length:1803 Identity:446/1803 - (24%)
Similarity:692/1803 - (38%) Gaps:444/1803 - (24%)


- Green bases have known domain annotations that are detailed below.


Human  2901 TAIVDVTVTDVNDSPPRFTAEIYKGTVSED-DPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
            |..|.:.:.|.|||||.|...:|:..:.|: |.|..|:    |.:|.....:..:.|.||||:..
  Fly    19 TKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVL----TVNAKDHNESTNIRYQITGGNIG 79

Human  2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEKTLYS 3029
            ..|||:....  .:||..|||.|.|..|.|.:.||....::...|.:.|.|.|||.||.::..|.
  Fly    80 NAFAVQNTTG--VIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYR 142

Human  3030 DTIPED---VLPGKLIMQISATDADIRSNAEITYTLLGSGAE-------KFKLNPDTGELKTSTP 3084
            ..|.|:   .|| |.|:|::|||.|:.....|.|.|.|.|.:       ||.:|..||::....|
  Fly   143 TQITEEDDRNLP-KRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKP 206

Human  3085 LDREE---QAVYHLLVRATDGGGR--FCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLL 3144
            |||::   :..:...|.|.|.||.  ...|.|.:.|:|:|||||:|....|...|.||...|:.:
  Fly   207 LDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSV 271

Human  3145 TRVQATDAD---AGLNRKILYSL----IDSADGQ--FSINELSGIIQLEK-PLDRELQAVYTLSL 3199
            ..:.|.|.|   ...|.|::||:    |:...|.  |.|...:|:|:... .||||....|::.:
  Fly   272 MTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQV 336

Human  3200 KAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSE---DILVGTEVLQVYAASRDIEA 3261
            .|:|.|   .|..|||..:.|.|:||.||.|...|:...|.|   ..:..|.:|.|.....| |.
  Fly   337 VAMDGG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED-ET 397

Human  3262 NAEITYSIISGNEHG--KFSI---DSKTGAVFIIENLDYE---SSHEYYLTVEATDGGT--PSLS 3316
            |. ..|.::..:..|  ||::   ...||::.||:.||||   .|..:...::..|.|.  |..|
  Fly   398 NT-FQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGS 461

Human  3317 D-----VATVNVNVTDINDNTPVFSQDTYTTVISED----AVLEQSVITVMADDADGPSNSHIHY 3372
            |     .:.|.|.:.|||||.|.|.::.....|.||    .:|||    ..|.|||...:|.:.|
  Fly   462 DKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQ----FKATDADQGGHSKVAY 522

Human  3373 SII-DGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDN 3436
            .|: ..|:...|.|.. ||.|.:.:.|||||...:.:.:.|.|:|||.|..|.|:.:.|.|||||
  Fly   523 KIVRSTNRKRQFAISD-RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDN 586

Human  3437 APVFSRGNYSVIIQENKPVGFSVLQLVVTDEDS--SHNGPPFFFTI--VTGNDEKA-FEV----- 3491
            ||.|:: :|...:.||.. |..:|::...|.|.  ..||.||.|.:  :..::.|| |:|     
  Fly   587 APTFAQ-DYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRR 649

Human  3492 --NPQGVLLTSS--AIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRV--IEESIYPPAILPLEI 3550
              |..||.:.||  ...|:.:..|.:.:::.|||.|.::..:.:.:.:  :.::...|....:.:
  Fly   650 GDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLV 714

Human  3551 FITSSGEEYSG----GVIGKIHATDQDVYDT--LTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQ 3609
            :      .|.|    ..||:::..|.|.:|.  ..|..:.|....|.:.:..|.|........|:
  Fly   715 Y------NYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGR 773

Human  3610 YLLNVSVTD---GKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYW----------- 3660
            |.|...|.|   |:....|:::|.:|.:|.|.:....::|.:::|.|:||.. |           
  Fly   774 YQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRT-WNPVKNQVEPSK 837

Human  3661 -RNFQRALRNILGVRRNDIQIVSLQSSE--PHPHLDVLLFVEKPGSAQISTKQLLHK---INSSV 3719
             ..|:..|..:|...|:::.:.|:|..|  |:|..||..      :|:.:|:|...|   :|..|
  Fly   838 LERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHF------AARSATQQPYFKAVRLNGVV 896

Human  3720 ----TDIEEIIGVRI--LNVFQKLCAGL-DCPWKFCDEKVSVDESVMSTHSTARLSFVTPRHHRA 3777
                .:||:.:|:.|  :|:.:.|..|. .|....|..||.:.:... |.|..|.:.|..|...:
  Fly   897 QMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKPY-TVSVNRTALVGVRLDIS 960

Human  3778 AVCLCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCV-CPSGRFGQCPGSSSMTLTGNSYVK 3841
            |.|:|:........|.|....|..|..||......|  || ||.|..|.....|:.:..||.:..
  Fly   961 AQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPK--CVACPVGYNGPRCQQSTRSFRGNGWAW 1023

Human  3842 Y---RLTENENKLEMKLTMRLRTYSTHAVVMYARG------------TDYSILEIHHGRLQYKFD 3891
            |   :|.:     |..|::...|.....:::| .|            :|:..||:..|..:...|
  Fly  1024 YPPLQLCQ-----ESHLSLEFITRVADGLILY-NGPIVPPKPEETVISDFIALELEQGYPRLLID 1082

Human  3892 CGSGPGIVSVQSIQ-VNDGQWHAVALEVNGNYARLVLDQVHT--------------------ASG 3935
            .|||...:.|::.: ::||.||.:.:..:....|:|:|...|                    |.|
  Fly  1083 FGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARG 1147

Human  3936 TAPGTLKTLNLDNYVFFGGHIRQ---QGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYA 3997
            ..|...::|||:..:..||..||   |...:.:......||.||:                |:..
  Fly  1148 QIPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCI----------------RNVI 1196

Human  3998 HIEESVDVS---------PGCFLT-----ATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTH 4048
            |..|..|::         |.|..|     .||..|.  |...|.|..|.... .|.|...::|..
  Fly  1197 HNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTAR--CWEHGNCVASLVQA-KCHCQPGWMGPG 1258

Human  4049 CEISVNPCSSKPCLY-------------------------GG----------------------- 4065
            |.:...|.:.|...|                         ||                       
  Fly  1259 CNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHL 1323

Human  4066 ------------------TCVVDNGG--------------------------------------F 4074
                              |.:..|.|                                      .
  Fly  1324 QFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLT 1388

Human  4075 VCQCRGLYTG-----------------------------------------------------QR 4086
            :.:..|:|.|                                                     :.
  Fly  1389 IDKQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERN 1453

Human  4087 CQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQS-------DIDECSGNPCLHGALCEN 4144
            |..:..|.:..|.:...|.|..:...|.|..|    |..|       |.:||...|||:||.|.|
  Fly  1454 CPSNRPCSNVICPDPFDCVDLWNEYECTCSEG----RIMSSDTKGCVDRNECLDLPCLNGATCIN 1514

Human  4145 THG--SYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLV--VVFVLCRKM 4205
            ...  .|.|.|...|.|.:||.....|      .:.|:.|....:||..|.:|:  ::|||    
  Fly  1515 LEPRLRYRCICPEGYWGENCELVQEGQ------RLKLSMGALGAIFVCLIIILILALIFVL---- 1569

Human  4206 ISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDR 4270
            .|||:|  ...|.|..||              .|::...:        |||    ..:.....|.
  Fly  1570 YSRKRK--TTKKKKRSGP--------------EKDVRETV--------ISY----EDEGGGEDDM 1606

Human  4271 NSFEGSAIPEHPEFSTFNPESVHGHRKAVAVCS---VAPNLPPPPPSNSPSDSDSIQKPSWDFDY 4332
            .:|:.:.:.        .|.|..|....:|.|.   :.|.:...||....:.:..:::.....|.
  Fly  1607 TAFDITPLQ--------IPISAQGGPPDIAACKMPIIYPVMTLLPPGQELNVAYLMEERKQRIDK 1663

Human  4333 DTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNE 4380
            |.         :..|.::..:..:....|::|  ||||..|.:.|:|:
  Fly  1664 DN---------NAPPFDDLRNFTFEGSGSIAE--SLSSLASGTDDENQ 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAT1XP_005262891.1 Cadherin_repeat 38..144 CDD:206637
Cadherin_repeat 153..252 CDD:206637
E_set 277..356 CDD:298831
Cadherin_repeat 371..459 CDD:206637
Cadherin_repeat 468..565 CDD:206637
Cadherin_repeat 575..663 CDD:206637
Cadherin_repeat 724..818 CDD:206637
Cadherin_repeat 826..923 CDD:206637
Cadherin_repeat 932..1016 CDD:206637
Cadherin_repeat 1042..1135 CDD:206637
Cadherin_repeat 1143..1241 CDD:206637
Cadherin_repeat 1250..1344 CDD:206637
Cadherin_repeat 1363..1452 CDD:206637
Cadherin_repeat 1461..1558 CDD:206637
Cadherin_repeat 1566..1658 CDD:206637
Cadherin_repeat 1671..1761 CDD:206637
Cadherin_repeat 1769..1874 CDD:206637
Cadherin_repeat 1895..1970 CDD:206637
Cadherin_repeat 1983..2077 CDD:206637
Cadherin_repeat 2085..2174 CDD:206637
Cadherin_repeat 2187..2279 CDD:206637
Cadherin_repeat 2287..2386 CDD:206637
Cadherin_repeat 2394..2488 CDD:206637
Cadherin_repeat 2496..2592 CDD:206637
Cadherin_repeat 2601..2694 CDD:206637
Cadherin_repeat 2708..2805 CDD:206637
Cadherin_repeat 2813..2913 CDD:206637 3/11 (27%)
Cadherin_repeat 2922..3019 CDD:206637 30/97 (31%)
Cadherin_repeat 3028..3121 CDD:206637 36/107 (34%)
Cadherin_repeat 3129..3226 CDD:206637 33/106 (31%)
Cadherin_repeat 3234..3331 CDD:206637 32/114 (28%)
Cadherin_repeat 3339..3436 CDD:206637 36/101 (36%)
Cadherin_repeat 3445..3536 CDD:206637 27/106 (25%)
Cadherin_repeat 3561..3634 CDD:206637 20/81 (25%)
LamG 3854..3985 CDD:214598 36/166 (22%)
EGF_CA 4016..4050 CDD:238011 8/33 (24%)
EGF_CA 4053..4088 CDD:238011 11/191 (6%)
EGF 4093..4123 CDD:278437 7/29 (24%)
EGF_CA 4127..4163 CDD:238011 15/37 (41%)
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 30/96 (31%)
Cadherin_repeat 140..248 CDD:206637 36/108 (33%)
Cadherin_repeat 256..359 CDD:206637 32/105 (30%)
Cadherin_repeat 379..481 CDD:206637 29/103 (28%)
Cadherin_repeat 489..586 CDD:206637 36/101 (36%)
Cadherin_repeat 594..703 CDD:206637 27/109 (25%)
Cadherin_repeat 724..801 CDD:206637 19/76 (25%)
EGF_CA 977..1010 CDD:238011 12/34 (35%)
LamG 1013..1198 CDD:238058 42/206 (20%)
EGF_2 <1233..1259 CDD:285248 7/26 (27%)
Laminin_G_2 1293..1428 CDD:280389 8/134 (6%)
EGF_CA 1497..1535 CDD:238011 15/37 (41%)
Cadherin_C 1583..1719 CDD:279398 28/163 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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