DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4C6 and adra1d

DIOPT Version :9

Sequence 1:	NP_001004704.1	Gene:	OR4C6 / 219432	HGNCID:	14743	Length:	309	Species:	Homo sapiens
Sequence 2:	XP_002935531.2	Gene:	adra1d / 100495969	XenbaseID:	XB-GENE-6050827	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	69/344 - (20%)
Similarity:	132/344 - (38%)	Gaps:	98/344 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    24 IFSAVFLVMYVATVLENLLIVVTIITSQSLRSPMYFFLTFLSLLDVMFSSVVAPKVIVDTLSKST 88
            |..|||::.   .::.|:::::::..::.|::...:|:..|::.|::.|:.|.|        .|.
Frog    47 IVLAVFILF---AIVGNIMVILSVACNRQLQTVTNYFIVNLAIADLLLSTTVLP--------FSA 100

Human    89 TISLKG--------CLTQLFVEHFFGGVGIILLTVMAYDRYVAICKPLHYTIIMSPRVCCLMVGG 145
            |:.:.|        |.....|:.......|:.|.|::.||||.:...|.|..||:.:...:::..
Frog   101 TLEVLGFWAFGRVFCDIWAAVDVLCCTASIMSLCVISIDRYVGVKYSLKYPTIMTEKKAVVILIL 165

Human   146 AWVGGFM---------------------------HAMIQLLFMYQIPFCGPNIIDHFICDLFQLL 183
            .|:...:                           :|:...||.:.:|..   :|   :...|::.
Frog   166 LWLSSMVISIGPLLGWKEPPPPDDSKCSITEEPGYALFSSLFSFYLPLL---VI---LVMYFRVY 224

Human   184 TLACTDTHIL--GLLVTLNSGMMCVAIFLILIASYTVILCSLKSYSSKGRHKALSTCSS------ 240
            .:|...|..|  |:....|..|..|    :.|...:|:   .:|.||...||..:..||
Frog   225 IVARRTTKSLEAGVKKERNKSMEVV----LRIHCRSVL---EESSSSTRNHKGHTFRSSLSVRLL 282

Human   241 ----------HLTVVVLFFVPC---IFLYMRPVVTHPIDK---AMAVSDSI---------ITPML 280
                      .|.:||..|:.|   .||.:      |:..   |:..:||:         ....:
Frog   283 KFSREKKAAKTLAIVVGVFILCWLPFFLIL------PLGSFFPALKPTDSVFKVIFWLGYFNSCV 341

Human   281 NPLIYTLRNAEVKSAMKKL 299
            ||:||...:.|.|.|..::
Frog   342 NPIIYPCSSKEFKRAFIRI 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4C6	NP_001004704.1	7tmA_OR4A-like	23..289	CDD:320605	66/332 (20%)
		TM helix 1	24..50	CDD:320605	5/25 (20%)
		TM helix 2	57..83	CDD:320605	6/25 (24%)
		TM helix 3	95..125	CDD:320605	9/29 (31%)
		TM helix 4	138..159	CDD:320605	2/47 (4%)
		TM helix 5	193..223	CDD:320605	7/31 (23%)
		TM helix 6	229..259	CDD:320605	11/48 (23%)
		TM helix 7	264..289	CDD:320605	8/36 (22%)
adra1d	XP_002935531.2	7tmA_alpha1D_AR	43..357	CDD:320450	68/339 (20%)
		TM helix 1	44..70	CDD:320450	5/25 (20%)
		TM helix 2	77..103	CDD:320450	8/33 (24%)
		TM helix 3	115..145	CDD:320450	9/29 (31%)
		TM helix 4	157..180	CDD:320450	1/22 (5%)
		TM helix 5	197..226	CDD:320450	6/34 (18%)
		TM helix 6	285..315	CDD:320450	8/35 (23%)
		TM helix 7	325..350	CDD:320450	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910