Protein Alignment FARSA and alpha-PheRS

DIOPT Version :10

• Sequence 1: NP_004452.1
• Gene: FARSA / 2193
• HGNCID: 3592
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_572448.1
• Gene: alpha-PheRS / 31740
• FlyBaseID: FBgn0030007
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 310/494 - (62%)
• Similarity: 388/494 - (78%)
• Gaps: 5/494 - (1%)

Human     6 VAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEI 70
            :.|.:|:.||.:|.. |:.:|||....:||.:||::||:||.||::.||..:.|...||.||..:
  Fly     5 LTERILQHLETTDKA-DTLDLAALFAEDHQKIVGSLKSIQAHGELVTAETVTHKSLGLTDEGRAV 68

Human    71 AREGSHEARVFRSIPPEGLAQSELMRL--PSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSME 133
            ...|||||.|:..:||||:||:.||..  .:.|||||||||:.||.||||... |.|.|.||::.
  Fly    69 VENGSHEALVYDLVPPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTP-PLVRRKVDTIT 132

Human   134 DEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMIS 198
            |.|:.:||.|..|:.::|..||.::.:|||||.|.|.|::.:::|..|:|:::|.||:|:.||::
  Fly   133 DVVRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTVEMLA 197

Human   199 SGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALF 263
            :|.|....||.|||.|.|..|..||||||||||::||||||||||:||||:|::||||||||||:
  Fly   198 NGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNFDALY 262

Human   264 QPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHT 328
            |||||||||.|||||:..||::.:.|.||::|||:.||.|||||:||.|:|||:||:||||||||
  Fly   263 QPQQHPARDAHDTFFVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHT 327

Human   329 TSASARALYRLA-QKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLR 392
            |:.|||.||:|| |:..|...||||||:|||||||||||||||||:|||:||.|||||.|:|.|.
  Fly   328 TAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGDLIGTLY 392

Human   393 EFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAW 457
            |||.|||||||.||||||||||||||:|.||.||.||:||||||||||||||||||||||:||||
  Fly   393 EFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPENVNVIAW 457

Human   458 GLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLD 496
            ||||||||||||||||||:|||.||:|:||.:.|:||||
  Fly   458 GLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FARSA	NP_004452.1	PTZ00326	1..484	CDD:240361	302/480 (63%)
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	308/492 (63%)