DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALDH1B1 and CG31075

DIOPT Version :9

Sequence 1:	NP_000683.3	Gene:	ALDH1B1 / 219	HGNCID:	407	Length:	517	Species:	Homo sapiens
Sequence 2:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	287/511 - (56%)
Similarity:	372/511 - (72%)	Gaps:	8/511 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     2 LRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIG 66
            |:.|....|::..:.:::....|...|      .|.|||||||:.|:||.|||.|.||.|.:.|.
  Fly     5 LQKLLAHQLAVSRKWSKFDHTYAQCEP------NYCQLFINNEFVDSVSGKTFATFNPATSKEIV 63

Human    67 HVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPF 131
            .|:|||:||:|.|||||::||...|.||::...:|..|:|:|..|::||:.:||||||.|||||:
  Fly    64 QVSEGDKADIDLAVKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPY 128

Human   132 QESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKL 196
            .|: ..|:...|...:|:|||.||:.|.|||..| ....||.|||||.|||||||:||:|..||.
  Fly   129 AEA-LFDVTYSILTLQYYAGWTDKFFGDTIPAGG-FVSMTRKEPVGVVGQIIPWNYPLLMLAWKW 191

Human   197 APALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFT 261
            .||||.|.|::||.||||||:||::|:|.||||||.||:|::.|:||||||||:.|.|:.|||||
  Fly   192 GPALAVGCTIIMKPAEQTPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFT 256

Human   262 GSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTF 326
            ||.|:|.::.:||..||||||:||||||||.:|..|||::.|||..|||||.|.||.|||||||:
  Fly   257 GSVEIGRIVMQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTY 321

Human   327 VEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERF 391
            |.|.||:||:.:...|||.||||||||.:.|||||:|.:...:|||||:.|:||||||..||:|.
  Fly   322 VHEKIYDEFVAKAAAKAKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRI 386

Human   392 GERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKA 456
            |..|||::||||..|:||||||:||||||||.:|||..:||:::||||.:|||||.|.|.|::||
  Fly   387 GNVGFFVEPTVFSDVKDDMRIAQEEIFGPVQSIFKFSSLEEMIDRANNVQYGLAAGVITNDINKA 451

Human   457 MYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKV 512
            :.|...:.||:||:|.|:.|...|||||:|.||.|||||:|||..|.|.||:|:|:
  Fly   452 LKFANNVDAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMKL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALDH1B1	NP_000683.3	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	281/479 (59%)
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	281/474 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760