DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlr6 and Tl

DIOPT Version :9

Sequence 1:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	966	Identity:	203/966 - (21%)
Similarity:	339/966 - (35%)	Gaps:	312/966 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse    49 YSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISF--LSELRVLRLSHNRIRSLDFHVFLFNQ 111
            ::.|.|||:|.:|....:.||..:...:...||...|  |..|..:....|::|.:...:|....
  Fly   157 FTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMP 221

Mouse   112 DLEYLDVSHNRLQNISCCPM---ASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLD 173
            .|:.|::..|:|.|::....   .|:..:|:..|..:.|| ...|.:||.:|.:.|||..||.|.
  Fly   222 KLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLP-HDVFAHLTNVTDINLSANLFRSLP 285

Mouse   174 LLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNAL------- 231
            .....|           :.|:......:.::|..|:      |:.||:.|..:.:..|
  Fly   286 QGLFDH-----------NKHLNEVRLMNNRVPLATL------PSRLFANQPELQILRLRAELQSL 333

Mouse   232 -GHL-----QLSNIKLNDENCQRLMTFLSE--------------LTRGPTLL-----NVTLQHIE 271
             |.|     |::||.|.|...:.|...|.|              ||..|..|     |:|...:|
  Fly   334 PGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLE 398

Mouse   272 TTWKCSVK--LFQFFWPRPVEYLNIYNLT--ITER-----IDREEFTYSETALKSLMIEHVKNQV 327
            ......:.  :|.          |:.||.  :..|     ||...|. |...|:.|.::|  |.:
  Fly   399 DNLLTGISGDIFS----------NLGNLVTLVMSRNRLRTIDSRAFV-STNGLRHLHLDH--NDI 450

Mouse   328 FLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLK-RLQ 391
            .|  ::.|..:..:..|      ::||.:|                        .|..||. |..
  Fly   451 DL--QQPLLDIMLQTQI------NSPFGYM------------------------HGLLTLNLRNN 483

Mouse   392 TLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLS--------- 447
            ::|...|..||         .|..|..||:|.|:::|..|:.....:::.|.:|::
  Fly   484 SIIFVYNDWKN---------TMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIAL 539

Mouse   448 ------------------------------------------------------------SNMLT 452
                                                                        .|:|.
  Fly   540 PEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLE 604

Mouse   453 GSVFRCLPP------------------------------KVKVLDLHNNRIMSIPK--DVTHLQA 485
            |:..|.:.|                              |..|::.|:..:..:|:  ::.....
  Fly   605 GTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQ 669

Mouse   486 LQELNVASNSLTDLPGCG--AFSSLSVLVIDHNSVSHPSED------------------------ 524
            |.||::.:|:|..||...  .:.|::.|.:..|:::....|
  Fly   670 LMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVL 734

Mouse   525 -FFQSCQNIRSLTAGNNPFQCTCELR-------DFVKNIG------WVAREVVEGWPDSYRCDYP 575
             |.......||:....||:.|.|..:       |..:.||      .|..|:.....:....|..
  Fly   735 GFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDIC 799

Mouse   576 ESSKGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLP-----W-YVRMLCQWTQ 634
            .:.||.             .:.|.|.|..|.|:...|.|   ||:...     | |...|..|..
  Fly   800 PAEKGV-------------FIALAVVIALTGLLAGFTAA---LYYKFQTEIKIWLYAHNLLLWFV 848

Mouse   635 TRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLE--KDDIRVCLHERNFVPGKSIVE 697
            |.        |:|.::.:|.||:|||..|.:::::.|:|.||  ....::|:|||:::.|..|.|
  Fly   849 TE--------EDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPE 905

Mouse   698 NIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYHKL 762
            ||:..:..|.:.|.|||.:||:|||...|...||.:..:||...:|:|:...|  .::.....:|
  Fly   906 NIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDI--GDVEKLDEEL 968

Mouse   763 RALMAQRTYLEWPTEKGKRGLFWANLRASF-------------IMKLALVNEDDVK 805
            :|.:...|||:|...     .||..||.:.             ::|.||....|.|
  Fly   969 KAYLKMNTYLKWGDP-----WFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380	6/14 (43%)
		PLN00113	50..>540	CDD:215061	122/664 (18%)
		leucine-rich repeat	65..88	CDD:275378	6/24 (25%)
		LRR_8	87..144	CDD:404697	12/59 (20%)
		leucine-rich repeat	89..112	CDD:275378	4/22 (18%)
		leucine-rich repeat	113..133	CDD:275378	5/22 (23%)
		leucine-rich repeat	134..158	CDD:275378	6/23 (26%)
		leucine-rich repeat	184..206	CDD:275380	1/21 (5%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..314	CDD:275380	8/30 (27%)
		leucine-rich repeat	315..343	CDD:275380	6/27 (22%)
		leucine-rich repeat	344..365	CDD:275380	4/20 (20%)
		leucine-rich repeat	390..415	CDD:275380	5/24 (21%)
		leucine-rich repeat	416..440	CDD:275380	7/23 (30%)
		leucine-rich repeat	441..462	CDD:275380	7/119 (6%)
		leucine-rich repeat	463..485	CDD:275380	3/23 (13%)
		leucine-rich repeat	486..508	CDD:275380	7/23 (30%)
		leucine-rich repeat	510..531	CDD:275380	4/45 (9%)
		LRRCT	540..594	CDD:214507	12/66 (18%)
		TIR	652..791	CDD:214587	48/140 (34%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	13/58 (22%)
		leucine-rich repeat	176..198	CDD:275380	6/21 (29%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR_RI	216..542	CDD:238064	84/397 (21%)
		LRR_8	221..281	CDD:290566	17/60 (28%)
		leucine-rich repeat	223..270	CDD:275380	12/47 (26%)
		leucine-rich repeat	271..294	CDD:275380	8/33 (24%)
		leucine-rich repeat	295..320	CDD:275380	6/30 (20%)
		leucine-rich repeat	321..343	CDD:275380	3/21 (14%)
		LRR_8	342..402	CDD:290566	15/59 (25%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		LRR_8	390..450	CDD:290566	16/72 (22%)
		leucine-rich repeat	392..415	CDD:275380	4/32 (13%)
		leucine-rich repeat	416..439	CDD:275380	6/23 (26%)
		leucine-rich repeat	440..474	CDD:275380	10/67 (15%)
		leucine-rich repeat	475..498	CDD:275380	8/31 (26%)
		LRR_8	477..534	CDD:290566	17/65 (26%)
		leucine-rich repeat	499..520	CDD:275380	7/20 (35%)
		leucine-rich repeat	523..552	CDD:275380	2/28 (7%)
		LRRCT	561..619	CDD:214507	5/57 (9%)
		LRRNT	631..667	CDD:214470	4/35 (11%)
		leucine-rich repeat	664..693	CDD:275380	7/28 (25%)
		LRR_8	669..726	CDD:290566	11/56 (20%)
		leucine-rich repeat	694..715	CDD:275380	3/20 (15%)
		leucine-rich repeat	716..737	CDD:275380	0/20 (0%)
		LRRCT	751..800	CDD:214507	10/48 (21%)
		TIR	858..996	CDD:214587	48/144 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020