DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlr6 and Toll-7

DIOPT Version :9

Sequence 1:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	796	Identity:	166/796 - (20%)
Similarity:	284/796 - (35%)	Gaps:	274/796 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 SNELESMVDYSNRNL-THVPKDLPPRT--------------KALSLSQNSISELRMPDISFLSEL 89
            :|..|.:....:..| ||..:..|.||              ..|.|..|::.:|....:..:..|
  Fly   151 NNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNL 215

Mouse    90 RVLRLSHNRIRSLDFHVFL----------FNQDLEYLDVSHNRLQNIS----CCPMASLRHLDLS 140
            :||.|:.||||:.:...|.          ...:|:.||.|||.|::||    ...:..|:||:|:
  Fly   216 QVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLA 280

Mouse   141 FNDFDVLPVCKEFGNLTKLT---FLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESL 202
            :|            ||::|:   ..||:                                   ||
  Fly   281 YN------------NLSELSGEALAGLA-----------------------------------SL 298

Mouse   203 QIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRG-----PTL 262
            :|.|.:..||...|..||:          |..:|..|.|....       |.||.:|     ..|
  Fly   299 RIVNLSNNHLETLPEGLFA----------GSKELREIHLQQNE-------LYELPKGLFHRLEQL 346

Mouse   263 L-------NVTLQHIE-TTWKCSVKLFQFFWPRPVEYLNIYNLTITERID----REEFTYSETAL 315
            |       .:|..|:: ||:...::|.         .||:.:..:| |||    :|.:......|
  Fly   347 LVVDLSGNQLTSNHVDNTTFAGLIRLI---------VLNLAHNALT-RIDYRTFKELYFLQILNL 401

Mouse   316 KSLMIEHVKNQVFLFSKEALYSVFAEMNI---KMLSISDTPF--IHMVCPPSPSSFTFLNFTQNV 375
            ::..|.|:::..||    .||::.. :|:   ::.::.|..|  ::::     |..|..|...:|
  Fly   402 RNNSIGHIEDNAFL----PLYNLHT-LNLAENRLHTLDDKLFNGLYVL-----SKLTLNNNLISV 456

Mouse   376 FTDSVFQGCSTLKR--------------------LQTLILQRNGLKNF----FK----------- 405
            ...:||:.||.||.                    |:||.|..|.::.|    ||
  Fly   457 VEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLI 521

Mouse   406 -------VALMTKNMSSLETLDVSLN---SLNSHAYDR-------------------TCAWAESI 441
                   ...|.:::..|..|:::.|   |:...::|:                   ..|...|:
  Fly   522 DNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSL 586

Mouse   442 LVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQE------LNVASNSLTDLP 500
            |.||||.|.|....:..:|..:|.||:|.|.|.::    .:...|||      |:.:.|.:|::.
  Fly   587 LWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL----GNYYKLQEEIRVKTLDASHNRITEIG 647

Mouse   501 GCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLT----------------------------- 536
            .....:::.:|.|::|.:.:...:.|....|:..:.
  Fly   648 PMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFY 712

Mouse   537 AGNNPFQCTCELRDFVKNIGWVAREVVEGWPD--SYRCDYPESSKGTALRDFHMSPLS------- 592
            .|.|||:|.|.: |:::.|..:.........|  :..|..|. ::|.|:|     |||
  Fly   713 LGGNPFECDCTM-DWLQRINNLTTRQHPRVMDMANIECVMPH-ARGAAVR-----PLSGLRPQDF 770

Mouse   593 -------CDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRML-CQWTQTRHRARHIPLEE--- 646
                   |..:.......|....:.......| |.|..|...:: |...||....|.:|::.
  Fly   771 LCRYESHCFALCHCCDFDACDCEMTCPSNCTC-YHDQIWSTNVVDCGGQQTTELPRRVPMDSSVV 834

Mouse   647 -LQRN----LQFHAFV 657
             |..|    |:.|||:
  Fly   835 YLDGNNFPVLKNHAFI 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380	4/17 (24%)
		PLN00113	50..>540	CDD:215061	131/642 (20%)
		leucine-rich repeat	65..88	CDD:275378	5/36 (14%)
		LRR_8	87..144	CDD:404697	23/70 (33%)
		leucine-rich repeat	89..112	CDD:275378	9/32 (28%)
		leucine-rich repeat	113..133	CDD:275378	9/23 (39%)
		leucine-rich repeat	134..158	CDD:275378	7/23 (30%)
		leucine-rich repeat	184..206	CDD:275380	3/21 (14%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..314	CDD:275380	7/27 (26%)
		leucine-rich repeat	315..343	CDD:275380	7/27 (26%)
		leucine-rich repeat	344..365	CDD:275380	2/25 (8%)
		leucine-rich repeat	390..415	CDD:275380	9/46 (20%)
		leucine-rich repeat	416..440	CDD:275380	6/45 (13%)
		leucine-rich repeat	441..462	CDD:275380	8/20 (40%)
		leucine-rich repeat	463..485	CDD:275380	6/21 (29%)
		leucine-rich repeat	486..508	CDD:275380	6/27 (22%)
		leucine-rich repeat	510..531	CDD:275380	4/20 (20%)
		LRRCT	540..594	CDD:214507	16/69 (23%)
		TIR	652..791	CDD:214587	3/6 (50%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	11/49 (22%)
		leucine-rich repeat	136..159	CDD:275380	2/7 (29%)
		leucine-rich repeat	160..190	CDD:275380	6/29 (21%)
		LRR_8	189..259	CDD:290566	19/69 (28%)
		leucine-rich repeat	191..214	CDD:275380	4/22 (18%)
		leucine-rich repeat	215..248	CDD:275380	9/32 (28%)
		LRR_RI	247..501	CDD:238064	75/337 (22%)
		LRR_8	247..308	CDD:290566	23/107 (21%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	10/69 (14%)
		LRR_8	297..356	CDD:290566	19/75 (25%)
		leucine-rich repeat	298..321	CDD:275380	9/32 (28%)
		leucine-rich repeat	322..345	CDD:275380	7/29 (24%)
		LRR_8	345..406	CDD:290566	15/70 (21%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	8/32 (25%)
		leucine-rich repeat	396..419	CDD:275380	6/26 (23%)
		LRR_8	419..478	CDD:290566	13/64 (20%)
		leucine-rich repeat	420..443	CDD:275380	3/23 (13%)
		leucine-rich repeat	444..467	CDD:275380	7/27 (26%)
		LRR_RI	466..622	CDD:238064	33/159 (21%)
		leucine-rich repeat	468..488	CDD:275380	2/19 (11%)
		LRR_8	491..549	CDD:290566	12/57 (21%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	1/20 (5%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	1/21 (5%)
		leucine-rich repeat	586..626	CDD:275380	14/43 (33%)
		leucine-rich repeat	627..653	CDD:275380	6/25 (24%)
		LRRCT	716..772	CDD:214507	16/62 (26%)
		LRRNT	796..830	CDD:214470	9/34 (26%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	6/18 (33%)
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920