DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tlr6 and Tehao

DIOPT Version :9

Sequence 1:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus
Sequence 2:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	198/891 - (22%)
Similarity:	323/891 - (36%)	Gaps:	243/891 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 PIVGSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPD 82
            |:|..|..:..|....|.:.|                      ||  |..|.||         |.
  Fly     6 PVVWLFFALLVLRSATGQIIP----------------------LP--TFCLGLS---------PQ 37

Mouse    83 ISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEY---LDVSHNRLQNISCCPMASLRHLDLSFNDF 144
            .:..:|..|:|               |:...||   |:||.         |.|||.....:..:.
  Fly    38 CTCAAEGNVVR---------------FHCPDEYAMLLEVSE---------PGASLYMSYYASTEL 78

Mouse   145 DVLPVCKEFGNLTKLTF-----------------LGLSAAK---FRQLDLLPVAHLHLSCILLDL 189
            ..||.. ...:|.|:.|                 ||:...|   ||...|..|       :..|:
  Fly    79 QWLPRF-NISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETV-------VTRDV 135

Mouse   190 VSYHIKGGETESLQIPNTTVLHL---------------------VFHP-NSLFSVQVNMSVNALG 232
            :  :...|..|:.|..|.|..|.                     :||. ::|..:.::::|..|.
  Fly   136 L--NSGNGYMETSQPENITTWHFGSVPGLKKFKFFSHVPELQESIFHGFDTLRDLHLSVNVTTLP 198

Mouse   233 HLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPR-----PVEYL 292
            ...||.:.      ..|.|...|.....:..|..|:.::.....|:.|...|..|     |..:.
  Fly   199 GNMLSTVN------GTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFG 257

Mouse   293 NIYNL------TITERIDREEF--TYSETALK-----SLMIEHVKNQVFLFSKEALYSVFAEMNI 344
            ::.||      :.|..::|..|  |.....:|     .||  .:..::||          .::|:
  Fly   258 SMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGNDDLM--ELPGEIFL----------DQVNL 310

Mouse   345 KMLSISDTPFI--HMVCPPSPSSFTFLNFTQNVFTD---SVFQGCSTLKRLQTLILQRNGLKNFF 404
            |.|.:|....:  |........:.|.|:.::|..|:   ::|   :.|..|..|.|.:|.|
  Fly   311 KTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIF---APLTSLNVLRLNKNSL---- 368

Mouse   405 KVALMTKNMSSLETLDVSLN---SLNSHAYDRTCAW-AESILVLNLSSNMLTGSVFRCLPPKV-- 463
                 |....|:....||||   .:|:..|..|... .|:::..|..:.....:.::|.|..:
  Fly   369 -----TAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICW 428

Mouse   464 -------KVLDLHNNRIMSIPKDVTHLQALQE-LNVASNSLTDLPGC---GAFSSLSVLVI-DHN 516
                   .::|.....:..:| |:.....|.. |.|.:||||.||..   ..::::|.|.: |:|
  Fly   429 VQRSVGSLIVDCRGTSLEELP-DLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNN 492

Mouse   517 SVSHPSED-------------------------FFQSCQNIRSLTAGNNPFQCTCE---LRDFVK 553
            ..|..|.|                         |.|...|..:|:...||..|.||   |..||:
  Fly   493 LTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVR 557

Mouse   554 NIGWVAREVVEGWPDSYRCDYPESSKGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCL 618
            ......|::.:     ..|...:.| ...:..|.:.|  ...:|::..:|..::|:.:...|..:
  Fly   558 TNPQRVRDIAD-----IVCTKQKKS-FQQMEAFELCP--SYVLLISCVVGGLVIVICLLTVFYLM 614

Mouse   619 Y---FDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEK--D 678
            :   ..:..|...||.|        .:..|||.::..:.||:|||..|...: ::|||.||.  .
  Fly   615 FQQELKIWLYNNNLCLW--------WVSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPH 670

Mouse   679 DIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLI 743
            ..|:|||:|:::.|..|.|.|:..::.|.:.|.|||.|||.|.|...|...|:.....:....:|
  Fly   671 PFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRII 735

Mouse   744 LILLEPI-LQNNIPSRYHKLRALMAQRTYLEWPTEKGKRGLFWANL 788
            :||...: ..|.|.|   :|||.:...|||:|...     |||:.|
  Fly   736 IILYRELEHMNGIDS---ELRAYLKLNTYLKWGDP-----LFWSKL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380	2/16 (13%)
		PLN00113	50..>540	CDD:215061	119/600 (20%)
		leucine-rich repeat	65..88	CDD:275378	5/22 (23%)
		LRR_8	87..144	CDD:404697	13/59 (22%)
		leucine-rich repeat	89..112	CDD:275378	3/22 (14%)
		leucine-rich repeat	113..133	CDD:275378	6/22 (27%)
		leucine-rich repeat	134..158	CDD:275378	4/23 (17%)
		leucine-rich repeat	184..206	CDD:275380	4/21 (19%)
		leucine-rich repeat	207..230	CDD:275380	6/44 (14%)
		leucine-rich repeat	290..314	CDD:275380	6/31 (19%)
		leucine-rich repeat	315..343	CDD:275380	5/32 (16%)
		leucine-rich repeat	344..365	CDD:275380	4/22 (18%)
		leucine-rich repeat	390..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	416..440	CDD:275380	7/27 (26%)
		leucine-rich repeat	441..462	CDD:275380	3/20 (15%)
		leucine-rich repeat	463..485	CDD:275380	3/30 (10%)
		leucine-rich repeat	486..508	CDD:275380	9/25 (36%)
		leucine-rich repeat	510..531	CDD:275380	8/46 (17%)
		LRRCT	540..594	CDD:214507	13/56 (23%)
		TIR	652..791	CDD:214587	49/140 (35%)
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	5/27 (19%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..261	CDD:275380	5/27 (19%)
		LRR_RI	<261..370	CDD:238064	27/132 (20%)
		leucine-rich repeat	262..284	CDD:275380	5/21 (24%)
		leucine-rich repeat	285..309	CDD:275380	5/35 (14%)
		LRR_8	309..368	CDD:290566	15/61 (25%)
		leucine-rich repeat	310..333	CDD:275380	4/22 (18%)
		leucine-rich repeat	334..357	CDD:275380	6/25 (24%)
		leucine-rich repeat	358..381	CDD:275380	7/31 (23%)
		leucine-rich repeat	445..482	CDD:275380	11/37 (30%)
		LRR_8	459..516	CDD:290566	15/56 (27%)
		leucine-rich repeat	483..505	CDD:275380	7/21 (33%)
		LRR_4	486..521	CDD:289563	6/34 (18%)
		TIR	643..779	CDD:214587	49/140 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020