DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tlr4 and Toll-7

DIOPT Version :9

Sequence 1:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:920 Identity:200/920 - (21%)
Similarity:361/920 - (39%) Gaps:199/920 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse    58 IDLSFNPL--KILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGS 120
            :|||.|.|  ..:.:.:|:....|..|:|:...:..|:.:.:..|:.|..|.|..|.|......:
  Fly   349 VDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNA 413

Mouse   121 FSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNY 185
            |..|.:|..|...|.:|.:|:......|..|.||.:.:|.| |...||.|.|.::|..:|||.|.
  Fly   414 FLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLI-SVVEPAVFKNCSDLKELDLSSNQ 477

Mouse   186 IQTI--TVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELT-LR------GNFN---S 238
            :..:  .:.||..||       :||:..|.|....:|:|:  .||:|| ||      ||..   .
  Fly   478 LNEVPRALQDLAMLR-------TLDLGENQIRTFDNQSFK--NLHQLTGLRLIDNQIGNITVGMF 533

Mouse   239 SNIMKTCLQNLAGLHVHRLILGEFKDERNLEI----FEPSIMEGLCDVTIDEFRLTYTNDFSDDI 299
            .::.:..:.|||...:..:..|.|  ::|.|:    .:.:.:..:..|......|.:.|...:.:
  Fly   534 QDLPRLSVLNLAKNRIQSIERGSF--DKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHL 596

Mouse   300 VKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQ------SLSIIRCQLKQFPTLDLPFLKSLTLTM 358
            |.|......|.:....:...|:|.:..::|.|      :|.....::.:...:.:|....|....
  Fly   597 VWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFIN 661

Mouse   359 NK--GSI---SFKKVALPSLSYLDLSRNALS---------------------------FSGCCSY 391
            |.  |::   :|  |...:|:.:||..|.||                           |...|:.
  Fly   662 NNLIGNVQPNAF--VDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTM 724

Mouse   392 SDL-GTNSL------RHLDLSFNGAIIMSANFMGLEELQHL--------------------DFQ- 428
            ..| ..|:|      |.:|::....::..|....:..|..|                    ||. 
  Fly   725 DWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDA 789

Mouse   429 --------------HSTL----------KRVTEFSAFLSLE-KLLYLDISYTNTKIDFDGIFLGL 468
                          |..:          ::.||....:.:: .::|||  ..|..:..:..|:|.
  Fly   790 CDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLD--GNNFPVLKNHAFIGR 852

Mouse   469 TSLNTLKMAGNSFKDNTLSN-VFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLF 532
            .:|..|.:.|:...  .:.| .||:..:|..|.|:..:|..:....|:.|..|:.|.:.:|.|..
  Fly   853 KNLRALYVNGSQVA--AIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTT 915

Mouse   533 LDSSHYNQLYSLSTLDCSFNRIETSKGILQ----HFPKSLAFFNLTNNSVACICEHQKFLQ---- 589
            ::::....|.:|..:....||:.|.. |.|    ||...|...:|..|..:|.|:   |||    
  Fly   916 IENATLAPLAALELIRIDGNRLVTLP-IWQMHATHFGTRLKSISLGRNQWSCRCQ---FLQALTS 976

Mouse   590 WVKEQKQFLVNVEQMTC--------ATPVEMNTS-------LVLDFN--NSTC------------ 625
            :|.:....:.:.:.:.|        :..:|.::|       ..||||  .:.|            
  Fly   977 YVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQH 1041

Mouse   626 -----YMYKTIISVSVVSVIVVSTVAFL------IYHFYFHLILIAG--CKKYSRGESIYDAFVI 677
                 |:.....:::::.::||..:.|.      |:.|..:.:.:.|  |::   .|.:|||.::
  Fly  1042 GIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEE---SEKLYDAVLL 1103

Mouse   678 YSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQ--EGFHKSRKVIVVVSRHFI 740
            :|:::.::|...|...||.|.|...:||.:||    :|..|...|  |....||:|:::::|:|:
  Fly  1104 HSAKDSEFVCQHLAAQLETGRPPLRVCLQHRD----LAHDATHYQLLEATRVSRRVVILLTRNFL 1164

Mouse   741 QSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTY--LEWEDNPLGRH 803
            |:.|...|.. ......|..|...:.|:.|..........:||...|..:..  :...|    ||
  Fly  1165 QTEWARCELR-RSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSD----RH 1224

Mouse   804 IFWRRLKNAL 813
             ||.:|:.||
  Fly  1225 -FWEKLRYAL 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tlr4NP_067272.1 LRR_8 53..113 CDD:290566 15/56 (27%)
LRR 1 54..75 6/18 (33%)
leucine-rich repeat 58..78 CDD:275380 6/21 (29%)
LRR 2 78..99 4/20 (20%)
leucine-rich repeat 79..102 CDD:275380 5/22 (23%)
LRR 3 102..123 6/20 (30%)
leucine-rich repeat 103..126 CDD:275380 7/22 (32%)
LRR 4 126..147 5/20 (25%)
leucine-rich repeat 127..150 CDD:275380 6/22 (27%)
LRR_8 150..214 CDD:290566 22/65 (34%)
LRR 5 150..171 8/20 (40%)
leucine-rich repeat 151..175 CDD:275380 10/23 (43%)
LRR 6 175..198 7/24 (29%)
leucine-rich repeat 176..204 CDD:275380 9/29 (31%)
LRR 7 204..224 6/19 (32%)
leucine-rich repeat 205..226 CDD:275380 6/20 (30%)
LRR 8 226..247 8/30 (27%)
LRR 9 248..269 6/20 (30%)
LRR 10 329..349 3/25 (12%)
leucine-rich repeat 331..350 CDD:275380 2/24 (8%)
LRR 11 350..370 5/24 (21%)
leucine-rich repeat 351..372 CDD:275380 5/25 (20%)
LRR_RI <369..555 CDD:238064 47/266 (18%)
LRR 12 372..392 8/46 (17%)
leucine-rich repeat 373..398 CDD:275380 9/52 (17%)
LRR 13 398..420 4/27 (15%)
leucine-rich repeat 399..421 CDD:275380 4/27 (15%)
LRR 14 421..442 7/65 (11%)
leucine-rich repeat 422..446 CDD:275380 7/69 (10%)
LRR 15 446..467 5/20 (25%)
leucine-rich repeat 447..470 CDD:275380 6/22 (27%)
LRR 16 470..490 4/20 (20%)
leucine-rich repeat 471..495 CDD:275380 6/24 (25%)
LRR_8 494..554 CDD:290566 13/59 (22%)
LRR 17 495..516 5/20 (25%)
leucine-rich repeat 496..519 CDD:275380 6/22 (27%)
LRR 18 519..540 4/20 (20%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 19 543..564 6/24 (25%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 41/148 (28%)
TIR 672..813 CDD:214587 39/144 (27%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 46/159 (29%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566 4/6 (67%)
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566 15/56 (27%)
leucine-rich repeat 346..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..395 CDD:275380 5/22 (23%)
leucine-rich repeat 396..419 CDD:275380 7/22 (32%)
LRR_8 419..478 CDD:290566 21/59 (36%)
leucine-rich repeat 420..443 CDD:275380 6/22 (27%)
leucine-rich repeat 444..467 CDD:275380 10/23 (43%)
LRR_RI 466..622 CDD:238064 38/166 (23%)
leucine-rich repeat 468..488 CDD:275380 5/19 (26%)
LRR_8 491..549 CDD:290566 19/66 (29%)
leucine-rich repeat 491..514 CDD:275380 9/31 (29%)
leucine-rich repeat 515..536 CDD:275380 6/20 (30%)
leucine-rich repeat 539..562 CDD:275380 6/24 (25%)
leucine-rich repeat 563..585 CDD:275380 1/21 (5%)
leucine-rich repeat 586..626 CDD:275380 7/39 (18%)
leucine-rich repeat 627..653 CDD:275380 2/25 (8%)
LRRCT 716..772 CDD:214507 10/55 (18%)
LRRNT 796..830 CDD:214470 3/33 (9%)
leucine-rich repeat 812..829 CDD:275380 2/16 (13%)
leucine-rich repeat 833..854 CDD:275380 6/22 (27%)
LRR_8 853..913 CDD:290566 15/61 (25%)
leucine-rich repeat 855..878 CDD:275380 6/24 (25%)
LRR_4 878..918 CDD:289563 10/39 (26%)
leucine-rich repeat 879..902 CDD:275380 6/22 (27%)
leucine-rich repeat 903..926 CDD:275380 5/22 (23%)
leucine-rich repeat 927..953 CDD:275380 8/26 (31%)
TIR 1098..1235 CDD:214587 41/146 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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