DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tlr1 and Toll-6

DIOPT Version :9

Sequence 1:NP_001263374.1 Gene:Tlr1 / 21897 MGIID:1341295 Length:795 Species:Mus musculus
Sequence 2:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1118 Identity:207/1118 - (18%)
Similarity:361/1118 - (32%) Gaps:469/1118 - (41%)


- Green bases have known domain annotations that are detailed below.


Mouse    53 LDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVFK------------------------ 93
            ||||.|||..|..:...:||:|..|.||.||||.:|...|:                        
  Fly   205 LDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSS 269

Mouse    94 -----FNTELEYLDLSHNELKVILCHPTVSLKHLD-LSFNAFDALPIC-KEFGNMSQLQFLGLSG 151
                 .:.:|||||:|||:..|:..:...:|:.|. ||.|......|. |....:..||.|.||.
  Fly   270 SSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSS 334

Mouse   152 SRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETLHIVFPSKREFRFLLDVSVSTT 216
            :::.:...:|.|                  |..:.::.|                :|.:.|:|..
  Fly   335 NKIVALPTELFA------------------EQAKIIQEV----------------YLQNNSISVL 365

Mouse   217 IGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVETTW---NSFINILQIVWHTPVKY 278
            .....||:     ||     |:||          :|::|.:.:||   |:|:.::::|      .
  Fly   366 NPQLFSNL-----DQ-----LQAL----------DLSMNQITSTWIDKNTFVGLIRLV------L 404

Mouse   279 FSISN---VKLQGQLAFRMFNYSDTSLKALSIHQVVTDVFSFPQSYIYSIFANMN----IQNFTM 336
            .::|:   .||:.::...::.....:|:...:..:..|.|: |.:.::::..:.|    :..:.:
  Fly   405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFA-PMNNLHTLLLSHNKLKYLDAYAL 468

Mouse   337 SGTHMVHML-----------------C----------------PSQVSPFLH---VDFTDNLLT- 364
            :|.:::.:|                 |                |..:....|   ||..:|::| 
  Fly   469 NGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITV 533

Mouse   365 --DMVFKDCRNLVRLKTL-----SLQKNQLKNLENI-ILTSAK------------MT-SLQKLDI 408
              |..||...||..|:.:     ::..:..::|.|: ||..|:            || |:|.:.:
  Fly   534 MEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRL 598

Mouse   409 SQNSLRYSDG---GIPCAWTQSLLVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDV--- 467
            ..|.|...:|   .:|     |||.||:|.|.|....:..:|..::.||||.||:.|:....   
  Fly   599 DGNELNDINGLFSNMP-----SLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLD 658

Mouse   468 THLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQN-------------- 518
            :.|: ||.|:|:.|.|..:......:|:.:|.::.|.::....|.|....|              
  Fly   659 SELK-LQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTL 722

Mouse   519 -IRSLT--------------AGNNPFQCTCELRDFVKNIGWVA--------------------RE 548
             |:||.              .|.|||.|.|.: |:::.|..:.                    ||
  Fly   723 DIKSLRILPVWEHRALPEFYIGGNPFTCDCNI-DWLQKINHITSRQYPRIMDLETIYCKLLNNRE 786

Mouse   549 -----VVEGWPDSYRCDYP---------------------------------------------- 562
                 ::|..|..:.|.|.                                              
  Fly   787 RAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYS 851

Mouse   563 ----------------------------------------------------------------- 562
                                                                             
  Fly   852 EMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLED 916

Mouse   563 ----------------------ESSR---------------------GTALRDFHMSPLSCDTVL 584
                                  :|::                     |..|..|.:..||.:..|
  Fly   917 NHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYL 981

Mouse   585 LTVTI------------------------------------------------------------ 589
            :.:::                                                            
  Fly   982 VEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHY 1046

Mouse   590 -------GATMLVLAVTGAFLC---LYFDLPWYVRMLCQWTQTRHRARHI----P--LEELQRNL 638
                   |...|:|..|.||:.   |.|.|..|...|..|..:.:...:.    |  :::|.:..
  Fly  1047 MHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKER 1111

Mouse   639 QFHAFVSYSGHDSAWVKNELLPNLEKD-DIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSP 702
            ...|:.:||..|..:|...|...||.| ..::|||.|:......|.:.:|...|.:.:.:.|||.
  Fly  1112 PNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSK 1176

Mouse   703 HFIQSEWCHYELYFAHHNLFHEGSDNLILILLAPIPQYSIPTNY-HKLKTLMSRRTYLEWPTEKN 766
            :|:.:||..:|...|.|.|. :....::.||...:||..|..:. |.|:|    .|.:||..:| 
  Fly  1177 NFLYNEWSRFEYKSALHELV-KRRKRVVFILYGDLPQRDIDMDMRHYLRT----STCIEWDDKK- 1235

Mouse   767 KHGLFWANLRASI 779
                ||..||.::
  Fly  1236 ----FWQKLRLAL 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tlr1NP_001263374.1 PRK15370 <38..>133 CDD:185268 34/109 (31%)
LRR <48..317 CDD:227223 68/300 (23%)
leucine-rich repeat 50..73 CDD:275378 9/19 (47%)
LRR 1 54..77 10/22 (45%)
leucine-rich repeat 74..97 CDD:275378 10/51 (20%)
LRR 2 78..101 10/51 (20%)
leucine-rich repeat 98..118 CDD:275378 9/19 (47%)
LRR 3 102..125 7/23 (30%)
leucine-rich repeat 119..143 CDD:275378 7/25 (28%)
LRR 4 126..150 6/24 (25%)
leucine-rich repeat 144..156 CDD:275378 5/11 (45%)
LRR 5 151..175 2/23 (9%)
LRR 6 176..199 2/22 (9%)
LRR 7 200..223 3/22 (14%)
LRR 8 224..250 5/25 (20%)
LRR 9 251..278 7/29 (24%)
LRR 10 279..308 4/31 (13%)
LRR 11 309..337 4/31 (13%)
Interaction with bacterial lipopeptide. /evidence=ECO:0000250 316..319 0/2 (0%)
LRR 12 338..361 7/58 (12%)
leucine-rich repeat 355..376 CDD:275380 10/26 (38%)
LRR 13 362..388 7/33 (21%)
PRK15370 <377..>487 CDD:185268 37/134 (28%)
leucine-rich repeat 377..402 CDD:275380 8/43 (19%)
LRR 14 389..414 10/38 (26%)
leucine-rich repeat 403..427 CDD:275380 5/26 (19%)
LRR 15 415..437 8/24 (33%)
leucine-rich repeat 428..449 CDD:275380 8/20 (40%)
LRR 16 438..457 5/18 (28%)
leucine-rich repeat 450..472 CDD:275380 8/24 (33%)
LRR 17 458..478 7/22 (32%)
leucine-rich repeat 473..494 CDD:275380 6/20 (30%)
LRR 18 479..500 4/20 (20%)
leucine-rich repeat 495..518 CDD:275380 4/22 (18%)
LRR 19 501..524 7/51 (14%)
LRRCT 527..581 CDD:214507 19/232 (8%)
TIR 639..782 CDD:214587 42/143 (29%)
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566 15/30 (50%)
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 20/72 (28%)
leucine-rich repeat 229..249 CDD:275380 9/19 (47%)
LRR_RI 278..468 CDD:238064 50/250 (20%)
leucine-rich repeat 279..302 CDD:275380 10/22 (45%)
LRR_8 301..386 CDD:290566 27/138 (20%)
leucine-rich repeat 303..326 CDD:275380 6/22 (27%)
leucine-rich repeat 327..350 CDD:275380 8/40 (20%)
LRR 350..729 CDD:227223 86/427 (20%)
leucine-rich repeat 352..375 CDD:275380 6/43 (14%)
leucine-rich repeat 376..401 CDD:275380 9/34 (26%)
LRR_RI <401..626 CDD:238064 44/236 (19%)
leucine-rich repeat 402..425 CDD:275380 4/28 (14%)
leucine-rich repeat 426..449 CDD:275380 4/23 (17%)
leucine-rich repeat 450..473 CDD:275380 2/22 (9%)
leucine-rich repeat 474..497 CDD:275380 2/22 (9%)
leucine-rich repeat 498..518 CDD:275380 1/19 (5%)
leucine-rich repeat 521..544 CDD:275380 7/22 (32%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 5/22 (23%)
leucine-rich repeat 593..615 CDD:275380 5/26 (19%)
leucine-rich repeat 616..637 CDD:275380 8/20 (40%)
leucine-rich repeat 638..662 CDD:275380 7/23 (30%)
leucine-rich repeat 663..684 CDD:275380 6/20 (30%)
leucine-rich repeat 685..708 CDD:275380 4/22 (18%)
leucine-rich repeat 709..728 CDD:275380 2/18 (11%)
LRR_8 883..943 CDD:290566 1/59 (2%)
leucine-rich repeat 885..908 CDD:275380 0/22 (0%)
leucine-rich repeat 909..932 CDD:275380 0/22 (0%)
LRR_8 932..990 CDD:290566 7/57 (12%)
leucine-rich repeat 933..956 CDD:275380 1/22 (5%)
TIR 1114..1247 CDD:214587 42/141 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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